Micellization Behavior of Antidepressant Imipramine Hydrochloride Drug and Hydrotrope (Sodium Tosylate) Mixtures at Different Compositions and Temperatures in Different Media

2020 ◽  
Vol 65 (5) ◽  
pp. 2659-2672
Author(s):  
Malik Abdul Rub ◽  
Dileep Kumar
Keyword(s):  
Antidepressant Imipramine ◽  
Imipramine Hydrochloride ◽  
Micellization Behavior

scholarly journals Investigation of Solution Behavior of Antidepressant Imipramine Hydrochloride Drug and Non-Ionic Surfactant Mixture: Experimental and Theoretical Study

Polymers ◽  
2021 ◽  
Vol 13 (22) ◽  
pp. 4025
Author(s):  
Malik Abdul Rub ◽  
Naved Azum ◽  
Dileep Kumar ◽  
Muhammad Nadeem Arshad ◽  
Anish Khan ◽  
...  
Keyword(s):  
Mixed Micelles ◽  
Antidepressant Drug ◽  
Aqueous System ◽  
Attractive Interaction ◽  
Ionic Surfactant ◽  
Mixed Micellization ◽  
Antidepressant Imipramine ◽  
Imipramine Hydrochloride ◽  
Micellization Process ◽  
Uv Visible

In this paper, the interaction of imipramine hydrochloride (IMP, antidepressant drug) and a non-ionic surfactant Triton X-100 (TX-100) mixture in five different ratios through the tensiometric method in different solvents (aqueous/0.050 mol·kg−1 aqueous NaCl/0.250 mol·kg−1 aqueous urea (U)) were examined thoroughly at a temperature of 298 K. UV–Visible studies in an aqueous system of IMP + TX-100 mixtures were also investigated and discussed in detail. The pure (IMP and TX-100) along with the mixtures’ critical micelle concentration (cmc) were assessed by a tensiometric technique. The obtained deviation of the mixtures’ cmc values from their ideal values revealed the nonideal behavior of IMP + TX-100 mixtures amongst IMP and TX-100. Compared to aqueous systems, in the presence of aqueous NaCl, several changes in micelles/mixed micelles occurred, and hence a synergism/attractive interaction amongst components was found increased while in the existence of U, the synergism/attractive interaction between them decreased. The evaluated interaction parameter (βRb) value of mixed micelles showed the attractive or synergism between the IMP and TX-100. Various evaluated thermodynamic parameters in an aqueous system showed that the mixed micellization of the IMP + TX-100 mixture was an entropically spontaneous phenomenon, although the existence of salt in all studied systems can somewhat increase the spontaneity of the micellization process and in the aqueous U system, the spontaneity of the micellization process decreased. In an aqueous system, the interaction between IMP and TX-100 was also confirmed by UV–Visible study.

Targeting of LOX-1 by willow bark, its etoh-fraction and by the antidepressant imipramine

Planta Medica ◽  
2012 ◽  
Vol 78 (11) ◽  
Author(s):  
A Koptina ◽  
O Kelber ◽  
H Zeitler ◽  
H Abdel-Aziz ◽  
M Ludwig ◽  
...  
Keyword(s):  
Antidepressant Imipramine ◽  
Willow Bark

The effect of surfactant charge on micellization behavior

1997 ◽  
Vol 275 (8) ◽  
pp. 754-759 ◽  
Author(s):  
R. M. Minardi ◽  
P. C. Schulz ◽  
B. Vuano
Keyword(s):  
Micellization Behavior

Micellization behavior of anionic gemini surfactants-templated manufacture of cerium oxide nanoparticles

2018 ◽  
Vol 40 (3) ◽  
pp. 390-402
Author(s):  
Xueming Liao ◽  
Zhinong Gao ◽  
Yan Xia ◽  
Wenzhong Zhai ◽  
Chenchen Pan ◽  
...  
Keyword(s):  
Cerium Oxide ◽  
Gemini Surfactants ◽  
Cerium Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Micellization Behavior
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