Protein-Bound Anthocyanin Compounds of Purple Sweet Potato Ameliorate Hyperglycemia by Regulating Hepatic Glucose Metabolism in High-Fat Diet/Streptozotocin-Induced Diabetic Mice

2020 ◽  
Vol 68 (6) ◽  
pp. 1596-1608 ◽  
Author(s):  
Tian Jiang ◽  
Xiaoyan Shuai ◽  
Jia Li ◽  
Ning Yang ◽  
Li Deng ◽  
...  
Keyword(s):  
Glucose Metabolism ◽  
Sweet Potato ◽  
High Fat Diet ◽  
Diabetic Mice ◽  
High Fat ◽  
Hepatic Glucose Metabolism ◽  
Hepatic Glucose ◽  
Purple Sweet Potato

Combined Prednisolone Treatment and a High-Fat Diet in Mice Both Induce Hyperglycemia, but Alter Hepatic Glucose Metabolism Differentially

2011 ◽  
pp. P3-390-P3-390
Author(s):  
Anke J Laskewitz ◽  
Theo H van Dijk ◽  
Wim H Dokter ◽  
Marie-Jose van Lierop ◽  
Aldo Grefhorst ◽  
...  
Keyword(s):  
Glucose Metabolism ◽  
High Fat Diet ◽  
High Fat ◽  
Hepatic Glucose Metabolism ◽  
Prednisolone Treatment ◽  
Hepatic Glucose

scholarly journals The antihyperlipidaemic and hepatoprotective effect of Ipomoea batatas L. leaves extract in high-fat diet rats

2021 ◽  
Vol 10 (3) ◽  
pp. 558
Author(s):  
Nurkhasanah Mahfudh ◽  
Nanik Sulistyani ◽  
Muhammad Syakbani ◽  
Athifah Candra Dewi
Keyword(s):  
Sweet Potato ◽  
High Fat Diet ◽  
Ipomoea Batatas ◽  
Lipid Level ◽  
Hepatoprotective Effect ◽  
High Fat ◽  
Potato Leaf ◽  
Serum Glutamic Oxaloacetic Transaminase ◽  
Liver Histopathology ◽  
Purple Sweet Potato

The administration of high-fat diets can increase the body's lipid level and damage the organs. Purple sweet potato leaf (Ipomoea batatas L.) was reported as an antioxidant against free radicals. This study aimed to observe the sweet potato leaf extract's activity on decreasing lipid profile and hepatoprotective effect in high-fat diet fed rats. The treatment animals were divided into five groups, namely normal control, high-fat diet (HFD) control, the treatment group of purple sweet potato leaf extract (SPLE) doses 100 mg/kg BW, 200 mg/kg BW and 400 mg/kg BW which fed with high-fat diet for 14 days and SPLE for 28 days. After treatment was completed, the blood was collected for the detection of cholesterol, triglyceride, serum glutamic oxaloacetic transaminase (SGOT), and serum glutamic pyruvate transaminase (SGPT). After that, the animals were sacrificed, and a liver histopathology observation was conducted using Haematoxylien and Eosin staining. The result showed a significant decrease in cholesterol and triglyceride levels (p≤0.05) compared to the negative group in all treated groups. The SGOT and SGPT enzymes in all of treatment groups were also found to decrease compared with HFD control. The result was confirmed by the histopathological observations. The finding suggested the potency of SPLE for antihyperlipidaemic and hepatoprotective agent.

Vitamin A status affects weight gain and hepatic glucose metabolism in rats fed a high-fat diet

2019 ◽  
Vol 97 (5) ◽  
pp. 545-553 ◽  
Author(s):  
Heqian Kuang ◽  
Cheng-hsin Wei ◽  
Tiannan Wang ◽  
Jennifer Eastep ◽  
Yang Li ◽  
...  
Keyword(s):  
Glucose Metabolism ◽  
Vitamin A ◽  
Insulin Receptor ◽  
High Fat Diet ◽  
Glycogen Synthase ◽  
Mitogen Activated Protein Kinase ◽  
High Fat ◽  
Expression Levels ◽  
Hepatic Expression ◽  
Hepatic Glucose

Whether vitamin A (VA) has a role in the development of metabolic abnormalities associated with intake of a high-fat diet (HFD) is unclear. Sprague–Dawley rats after weaning were fed an isocaloric VA sufficient HFD (VAS-HFD) or a VA deficient HFD (VAD-HFD) for 8 weeks. Body mass, food intake, liver and adipose tissue mass, and the hepatic expression levels of key proteins for metabolism were determined. VAD-HFD rats had lower body, liver, and epididymal fat mass than VAS-HFD rats. VAD-HFD rats had lower hepatic protein expression levels of cytochrome P450 26A1, glucokinase, and phosphoenolpyruvate carboxykinase than VAS-HFD rats. VAD-HFD rats had higher protein levels of glycogen synthase kinase (GSK)-3α and lower levels of GSK-3β, but not glycogen synthase, than VAS-HFD rats. VAD-HFD rats had higher hepatic levels of insulin receptor substrate-1 (IRS-1), insulin receptor β-subunit, mitogen-activated protein kinase proteins, and peroxisome proliferator-activated receptor-gamma coactivator 1α mRNA, and lower level of IRS-2 protein than VAS-HFD rats. These results indicate that in a HFD setting, VA deficiency attenuated HFD-induced obesity, and VA status altered the expression levels of proteins required for glucose metabolism and insulin signaling. We conclude that VA status contributes to the regulation of hepatic glucose and lipid metabolism in a HFD setting, and may regulate hepatic carbohydrate metabolism.

scholarly journals Hepatic Glucose Metabolism in Late Pregnancy: Normal Versus High-Fat and -Fructose Diet

Diabetes ◽  
2012 ◽  
Vol 62 (3) ◽  
pp. 753-761 ◽  
Author(s):  
K. C. Coate ◽  
M. S. Smith ◽  
M. Shiota ◽  
J. M. Irimia ◽  
P. J. Roach ◽  
...  
Keyword(s):  
Glucose Metabolism ◽  
Late Pregnancy ◽  
High Fat ◽  
Hepatic Glucose Metabolism ◽  
Hepatic Glucose
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