Rice Bran Phenolic Extract Protects against Alcoholic Liver Injury in Mice by Alleviating Intestinal Microbiota Dysbiosis, Barrier Dysfunction, and Liver Inflammation Mediated by the Endotoxin–TLR4–NF-κB Pathway

2019 ◽  
Vol 68 (5) ◽  
pp. 1237-1247 ◽  
Author(s):  
Juan Xiao ◽  
Ruifen Zhang ◽  
Yujiao Wu ◽  
Chengjunhong Wu ◽  
Xuchao Jia ◽  
...  
Keyword(s):  
Liver Injury ◽  
Intestinal Microbiota ◽  
Rice Bran ◽  
Alcoholic Liver Injury ◽  
Liver Inflammation ◽  
Barrier Dysfunction ◽  
Phenolic Extract

scholarly journals Defining the temporal evolution of gut dysbiosis and inflammatory responses leading to hepatocellular carcinoma in Mdr2 −/− mouse model

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
J. Behary ◽  
A. E. Raposo ◽  
N. M. L. Amorim ◽  
H. Zheng ◽  
L. Gong ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Injury ◽  
Gut Microbiome ◽  
Temporal Evolution ◽  
Inflammatory Responses ◽  
Therapeutic Interventions ◽  
Liver Inflammation ◽  
Barrier Dysfunction ◽  
Gut Barrier ◽  
Gut Dysbiosis

Abstract Background Emerging evidence implicates the gut microbiome in liver inflammation and hepatocellular carcinoma (HCC) development. We aimed to characterize the temporal evolution of gut dysbiosis, in relation to the phenotype of systemic and hepatic inflammatory responses leading to HCC development. In the present study, Mdr2 −/− mice were used as a model of inflammation-based HCC. Gut microbiome composition and function, in addition to serum LPS, serum cytokines/chemokines and intrahepatic inflammatory genes were measured throughout the course of liver injury until HCC development. Results Early stages of liver injury, inflammation and cirrhosis, were characterized by dysbiosis. Microbiome functional pathways pertaining to gut barrier dysfunction were enriched during the initial phase of liver inflammation and cirrhosis, whilst those supporting lipopolysaccharide (LPS) biosynthesis increased as cirrhosis and HCC ensued. In parallel, serum LPS progressively increased during the course of liver injury, corresponding to a shift towards a systemic Th1/Th17 proinflammatory phenotype. Alongside, the intrahepatic inflammatory gene profile transitioned from a proinflammatory phenotype in the initial phases of liver injury to an immunosuppressed one in HCC. In established HCC, a switch in microbiome function from carbohydrate to amino acid metabolism occurred. Conclusion In Mdr2 −/− mice, dysbiosis precedes HCC development, with temporal evolution of microbiome function to support gut barrier dysfunction, LPS biosynthesis, and redirection of energy source utilization. A corresponding shift in systemic and intrahepatic inflammatory responses occurred supporting HCC development. These findings support the notion that gut based therapeutic interventions could be beneficial early in the course of liver disease to halt HCC development.

The ameliorative effects of probiotic‐fermented soymilk on acute alcoholic liver injury

2021 ◽  
Author(s):  
Yu Wang ◽  
Haiyue Sun ◽  
Yiying Chen ◽  
Wuyang Guan ◽  
Jun Zhang ◽  
...  
Keyword(s):  
Liver Injury ◽  
Alcoholic Liver Injury

Gut relief formula attenuates dextran sulfate sodium-induced colitis by regulating NF-κB signaling and the intestinal microbiota in mice

2021 ◽  
Author(s):  
Xuemeng Si ◽  
Ning Liu ◽  
Hai Jia ◽  
Jiaqi Wang ◽  
Lina Pan ◽  
...  
Keyword(s):  
Intestinal Microbiota ◽  
Dextran Sulfate ◽  
Dextran Sulfate Sodium ◽  
Mucosal Barrier ◽  
Mucosal Inflammation ◽  
Barrier Dysfunction

Gut relief formula administration alleviated mucosal inflammation and mucosal barrier dysfunction by inhibiting STAT3 and NF-κB activity and upregulating abundances of Lactobacillus in DSS-induced colitis.

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