Gut Microbiota and Metabolome Response of Decaisnea insignis Seed Oil on Metabolism Disorder Induced by Excess Alcohol Consumption

2019 ◽  
Vol 67 (38) ◽  
pp. 10667-10677 ◽  
Author(s):  
Xiaoxia Liu ◽  
Ke Zhao ◽  
Xingbin Yang ◽  
Yan Zhao
Keyword(s):  
Alcohol Consumption ◽  
Gut Microbiota ◽  
Seed Oil ◽  
Metabolism Disorder ◽  
Excess Alcohol Consumption

Innate gut microbiota predisposes to high alcohol consumption

2021 ◽  
Author(s):  
Fernando Ezquer ◽  
Maria Elena Quintanilla ◽  
Francisco Moya‐Flores ◽  
Paola Morales ◽  
José Manuel Munita ◽  
...  
Keyword(s):  
Alcohol Consumption ◽  
Gut Microbiota ◽  
High Alcohol ◽  
High Alcohol Consumption

scholarly journals Gut Microbiota Is Involved in Alcohol-Induced Osteoporosis in Young and Old Rats Through Immune Regulation

2021 ◽  
Vol 11 ◽  
Author(s):  
Ming Cheng ◽  
Bo Tan ◽  
Xiaojing Wu ◽  
Feng Liao ◽  
Fei Wang ◽  
...  
Keyword(s):  
Alcohol Consumption ◽  
Gut Microbiota ◽  
Bone Metabolism ◽  
Alcohol Metabolism ◽  
Excessive Alcohol Consumption ◽  
Young Rats ◽  
Age Related ◽  
Different Ages ◽  
Old Rats

Long-term and excessive alcohol consumption are risk factors for osteoporosis. Excessive drinking can reduce bone density and also cause imbalance of gut microbiota. And gut microbiota can affect bone metabolism through various mechanisms, and the regulation of gut microbiota is closely related to age. However, the effects of gut microbiota on alcohol-induced osteoporosis at different ages are unclear. In this study, young and old rats were used to induce osteoporosis by long-term alcohol consumption, and alcohol metabolism, bone morphology, bone absorption and immune activity of rats were analyzed to determine the effects of alcohol on rats of different ages. In addition, changes of gut microbiota in rats were analyzed to explore the role of gut microbiota in alcohol-induced osteoporosis in rats of different ages. The results showed the ability of alcohol metabolism was only associated with age, but not with alcohol consumption. Long-term alcohol consumption resulted in the changes of bone metabolism regulating hormones, bone loss, activation of receptor activator of NF-κB ligand (RANKL) signaling and inflammatory response. And osteoporosis was more severe in old rats than young rats, suggesting that alcohol-induced osteoporosis is age-related. In addition, long-term drinking also affected the composition of gut microbiota in rats, with a significant increase in the proportion of pro-inflammatory microorganisms. Overall, this study found that long-term alcohol consumption induced osteoporosis and affected the composition of gut microbiota. And alcohol can activate T lymphocytes directly or indirectly by regulating the changes of gut microbiota to produce cytokines, and further activate osteoclasts. In addition, the osteoporosis was more severe in the old rats than young rats, which may be due to the higher diversity and stronger regulation ability of gut microbiota in young rats compared with old rats.

scholarly journals Sa2032 – Alcohol Consumption and the Colonic Mucosa-Associated Gut Microbiota in Individuals Undergoing Screening Colonoscopy

2019 ◽  
Vol 156 (6) ◽  
pp. S-479
Author(s):  
Shawn Gurwara ◽  
Nadim Ajami ◽  
Hashem B. El-Serag ◽  
Joseph F. Petrosino ◽  
Li Jiao
Keyword(s):  
Alcohol Consumption ◽  
Gut Microbiota ◽  
Colonic Mucosa ◽  
Screening Colonoscopy

scholarly journals Essential Amino Acid Supplement Lowers Intrahepatic Lipid despite Excess Alcohol Consumption

Nutrients ◽  
2020 ◽  
Vol 12 (1) ◽  
pp. 254
Author(s):  
Melynda S. Coker ◽  
Kaylee R. Ladd ◽  
Jimin Kim ◽  
Carl J. Murphy ◽  
Ryan DeCort ◽  
...  
Keyword(s):  
Body Composition ◽  
Amino Acid ◽  
Alcohol Consumption ◽  
Essential Amino Acid ◽  
Blood Lipids ◽  
High Dose ◽  
Amino Acid Supplement ◽  
Acid Supplement ◽  
Intrahepatic Lipid ◽  
Excess Alcohol Consumption

Excess alcohol consumption is a top risk factor for death and disability. Fatty liver will likely develop and the risk of liver disease increases. We have previously demonstrated that an essential amino acid supplement (EAAS) improved protein synthesis and reduced intrahepatic lipid in the elderly. The purpose of this exploratory pilot study was to initiate the evaluation of EAAS on intrahepatic lipid (IHL), body composition, and blood lipids in individuals with mild to moderate alcohol use disorder (AUD). Following consent, determination of eligibility, and medical screening, 25 participants (18 males at 38 ± 15 years/age and 7 females at 34 ± 18 years/age) were enrolled and randomly assigned to one of two dosages: a low dose (LD: 8 g of EAAS twice/day (BID)) or high dose (HD: 13 g of EAAS BID). Five of the twenty-five enrolled participants dropped out of the intervention. Both groups consumed the supplement BID for 4 weeks. Pre- and post-EAAS administration, IHL was determined using magnetic resonance imaging/spectroscopy, body composition was analyzed using dual-energy X-ray absorptiometry, and blood parameters were measured by LabCorp. T-tests were used for statistical analysis and considered significant at p < 0.05. While there was no significant change in IHL in the LD group, there was a significant 23% reduction in IHL in the HD group (p = 0.02). Fat mass, lean tissue mass, bone mineral content, and blood lipids were not altered. Post-EAAS phosphatidylethanol was elevated and remained unchanged in LD at 407 ± 141 ng/mL and HD at 429 ± 196 ng/mL, indicating chronic and excess alcohol consumption. The HD of the proprietary EAAS formulation consumed BID seemed to lower IHL in individuals with mild to moderate AUD. We suggest that further studies in a larger cohort be conducted to more completely address this important area of investigation.

Virgin Grape Seed Oil Alleviates Insulin Resistance and Energy Metabolism Disorder in Mice Fed a High‐Fat Diet

2020 ◽  
Vol 122 (4) ◽  
pp. 1900158
Author(s):  
Xiaojing Li ◽  
Yingbin Shen ◽  
Jianhong Zhu ◽  
Junyong Xiao ◽  
Renhuai Cong ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Energy Metabolism ◽  
High Fat Diet ◽  
Seed Oil ◽  
Grape Seed ◽  
High Fat ◽  
Metabolism Disorder ◽  
Grape Seed Oil ◽  
Energy Metabolism Disorder
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