Liquiritin from Glycyrrhiza uralensis Attenuating Rheumatoid Arthritis via Reducing Inflammation, Suppressing Angiogenesis, and Inhibiting MAPK Signaling Pathway

2019 ◽  
Vol 67 (10) ◽  
pp. 2856-2864 ◽  
Author(s):  
Ke-feng Zhai ◽  
Hong Duan ◽  
Cai-yue Cui ◽  
Yu-yao Cao ◽  
Jia-li Si ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Signaling Pathway ◽  
Mapk Signaling ◽  
Mapk Signaling Pathway ◽  
Glycyrrhiza Uralensis

An involvement of SR-B1 mediated p38 MAPK signaling pathway in serum amyloid A-induced angiogenesis in rheumatoid arthritis

2015 ◽  
Vol 66 (2) ◽  
pp. 340-345 ◽  
Author(s):  
Chengcheng Hong ◽  
Chen Shen ◽  
Hongmei Ding ◽  
Shanshan Huang ◽  
Yun Mu ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Signaling Pathway ◽  
P38 Mapk ◽  
Serum Amyloid A ◽  
Mapk Signaling ◽  
Mapk Signaling Pathway ◽  
Serum Amyloid ◽  
Amyloid A

scholarly journals Transdermal delivery of fluvastatin sodium via tailored spanlastic nanovesicles: mitigated Freund's adjuvant-induced rheumatoid arthritis in rats through suppressing p38 MAPK signaling pathway

Drug Delivery ◽  
2019 ◽  
Vol 26 (1) ◽  
pp. 1140-1154 ◽  
Author(s):  
Shahira F. El Menshawe ◽  
Mohamed M. Nafady ◽  
Heba M. Aboud ◽  
Rasha M. Kharshoum ◽  
Asmaa Mohammed M. Hussein Elkelawy ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Signaling Pathway ◽  
P38 Mapk ◽  
Transdermal Delivery ◽  
Mapk Signaling ◽  
Mapk Signaling Pathway ◽  
Freund’S Adjuvant ◽  
Freund's Adjuvant

Wogonin ameliorate complete Freund's adjuvant induced rheumatoid arthritis via targeting NF‐κB/MAPK signaling pathway

BioFactors ◽  
2020 ◽  
Vol 46 (2) ◽  
pp. 283-291
Author(s):  
Yuntai Huang ◽  
Lubo Guo ◽  
Renukaradhya Chitti ◽  
Nagaraja Sreeharsha ◽  
Anurag Mishra ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Signaling Pathway ◽  
Mapk Signaling ◽  
Mapk Signaling Pathway ◽  
Complete Freund’S Adjuvant ◽  
Freund’S Adjuvant ◽  
Complete Freund's Adjuvant ◽  
Freund's Adjuvant

MAPK: A Key Player in the Development and Progression of Stroke

2020 ◽  
Vol 19 (4) ◽  
pp. 248-256
Author(s):  
Yangmin Zheng ◽  
Ziping Han ◽  
Haiping Zhao ◽  
Yumin Luo
Keyword(s):  
Ischemic Stroke ◽  
Signaling Pathway ◽  
Complex Disease ◽  
Therapeutic Targets ◽  
Cell Types ◽  
Mapk Signaling ◽  
Mapk Signaling Pathway ◽  
Effective Prevention ◽  
Prevention And Treatment ◽  
Different Cell Types

Conclusion: Stroke is a complex disease caused by genetic and environmental factors, and its etiological mechanism has not been fully clarified yet, which brings great challenges to its effective prevention and treatment. MAPK signaling pathway regulates gene expression of eukaryotic cells and basic cellular processes such as cell proliferation, differentiation, migration, metabolism and apoptosis, which are considered as therapeutic targets for many diseases. Up to now, mounting evidence has shown that MAPK signaling pathway is involved in the pathogenesis and development of ischemic stroke. However, the upstream kinase and downstream kinase of MAPK signaling pathway are complex and the influencing factors are numerous, the exact role of MAPK signaling pathway in the pathogenesis of ischemic stroke has not been fully elucidated. MAPK signaling molecules in different cell types in the brain respond variously after stroke injury, therefore, the present review article is committed to summarizing the pathological process of different cell types participating in stroke, discussed the mechanism of MAPK participating in stroke. We further elucidated that MAPK signaling pathway molecules can be used as therapeutic targets for stroke, thus promoting the prevention and treatment of stroke.

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