Design of Astaxanthin-Loaded Core–Shell Nanoparticles Consisting of Chitosan Oligosaccharides and Poly(lactic-co-glycolic acid): Enhancement of Water Solubility, Stability, and Bioavailability

2019 ◽  
Vol 67 (18) ◽  
pp. 5113-5121 ◽  
Author(s):  
Chengzhen Liu ◽  
Shuaizhong Zhang ◽  
David Julian McClements ◽  
Dongfeng Wang ◽  
Ying Xu
Keyword(s):  
Glycolic Acid ◽  
Water Solubility ◽  
Core Shell ◽  
Shell Nanoparticles ◽  
Chitosan Oligosaccharides ◽  
Core Shell Nanoparticles

scholarly journals Brinzolamide loaded core-shell nanoparticles for enhanced coronial penetration in the treatment of glaucoma

2020 ◽  
Vol 18 ◽  
pp. 228080002094271
Author(s):  
Jing Song ◽  
Ziping Zhang
Keyword(s):  
Glycolic Acid ◽  
Neurodegenerative Disorder ◽  
Treatment Strategies ◽  
Entrapment Efficiency ◽  
Single Step ◽  
Core Shell ◽  
Shell Nanoparticles ◽  
Cytotoxicity Studies ◽  
Electrospray Process ◽  
Core Shell Nanoparticles

A neurodegenerative disorder, glaucoma is a leading cause of blindness in the world. The conventional treatment strategies do not allow the significant penetration of the drug in the cornea. Therefore, we prepare a brinzolamide (Brz) loaded core-shell nanoparticles (NPs) to enhance the coronial penetration of the drug and thus treating the glaucoma. The shell of the NPs was composed of phosphatidylserine (PS; 1,2-diacyl-sn-glycero-3-phospho-L-serine), whereas the core of the NPs contains the Brz encapsulated in brinzolamide–phosphatidylserine–polymer poly-(DL-lactic acid-co-glycolic acid)–phosphatidylserine (Brz-PS-PLGA). The synthesis of Brz-PS-PLGA was achieved by using a coaxial electrospray process (CEP), which allows the preparation of the particles in a single step. The size of Brz-PS-PLGA with PS shell and brinzolamide–poly (lactic-co-glycolic) acid (Brz-PLGA) without shell was 571 ± 27.02 nm and 456 ± 19.17 nm, respectively. The charges on the surface of Brz-PS-PLGA and Brz-PLGA were (-) 27.45 ± 2.98 mV and (-) 19.47 ± 2.83 mV. The transmission electron microscopy images clearly reveal the PS shell as a light black layer over the dark black PLGA core. The CEP allows the high encapsulation of Brz in Brz-PS-PLGA where percentage of entrapment efficiency for Brz-PS-PLGA was 88.13 ± 6.43%. The release study conducted in a simulated tear fluid revealed the sustained release patterns of Brz from Brz-PS-PLGA and these were nontoxic to the cells as revealed by the cytotoxicity studies. Further, the Brz-PS-PLGA enhanced the coronial penetration of Brz and was capable of significantly reducing the intraocular pressure (IOP) after administration to the rabbit eye in comparison to the Brz-PLGA and free Brz. The results clearly suggest that the PS coating significantly enhances the capability of the particles in reducing IOP.

Preparation and Electrocatalytic Performance of Thin-shell Ni/Pt Core-shell Nanoparticles

2012 ◽  
Vol 27 (1) ◽  
pp. 95-101
Author(s):  
Shi-Bin LIU ◽  
Chun-Ying YANG ◽  
Zhong-Lin ZHANG ◽  
Dong-Hong DUAN ◽  
Xiao-Gang HAO ◽  
...  
Keyword(s):  
Thin Shell ◽  
Core Shell ◽  
Shell Nanoparticles ◽  
Electrocatalytic Performance ◽  
Core Shell Nanoparticles

Pluronic-Based Core/Shell Nanoparticles for Drug Delivery and Diagnosis

2013 ◽  
Vol 20 (28) ◽  
pp. 3488-3499 ◽  
Author(s):  
Yon Jung ◽  
Hwanbum Lee ◽  
Jae Kim ◽  
Eun Koo ◽  
Keun Oh ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Core Shell ◽  
Shell Nanoparticles ◽  
Core Shell Nanoparticles

Colorimetric and SERS dual-mode sensing of mercury (II) based on controllable etching of Au@Ag core/shell nanoparticles

2021 ◽  
Vol 330 ◽  
pp. 129364
Author(s):  
Jinhua Wang ◽  
Jiamin Wu ◽  
Yuping Zhang ◽  
Xia Zhou ◽  
Ziwei Hu ◽  
...  
Keyword(s):  
Core Shell ◽  
Dual Mode ◽  
Shell Nanoparticles ◽  
Core Shell Nanoparticles

Intermetallic FePt@PtBi Core–Shell Nanoparticles for Oxygen Reduction Electrocatalysis

2021 ◽  
Author(s):  
Jingyu Guan ◽  
Shaoxuan Yang ◽  
Tongtong Liu ◽  
Yihuan Yu ◽  
Jin Niu ◽  
...  
Keyword(s):  
Oxygen Reduction ◽  
Core Shell ◽  
Shell Nanoparticles ◽  
Core Shell Nanoparticles
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