Ochratoxin A Exposure Impairs Porcine Granulosa Cell Growth via the PI3K/AKT Signaling Pathway

2019 ◽  
Vol 67 (9) ◽  
pp. 2679-2690 ◽  
Author(s):  
Tian-Yu Zhang ◽  
Xiao-Feng Sun ◽  
Lan Li ◽  
Jin-Mei Ma ◽  
Rui-Qian Zhang ◽  
...  
Keyword(s):  
Cell Growth ◽  
Signaling Pathway ◽  
Ochratoxin A ◽  
Granulosa Cell ◽  
Akt Signaling ◽  
Akt Signaling Pathway ◽  
Porcine Granulosa Cell

scholarly journals miR‐130a promotes immature porcine Sertoli cell growth by activating SMAD5 through the TGF‐β‐PI3K/AKT signaling pathway

2020 ◽  
Vol 34 (11) ◽  
pp. 15164-15179
Author(s):  
Hui Luo ◽  
Bin Chen ◽  
Bo Weng ◽  
Xiangwei Tang ◽  
Yao Chen ◽  
...  
Keyword(s):  
Cell Growth ◽  
Signaling Pathway ◽  
Sertoli Cell ◽  
Akt Signaling ◽  
Akt Signaling Pathway

scholarly journals Aclarubicin regulates glioma cell growth and DNA damage through the SIRT1/PI3K/AKT signaling pathway

RSC Advances ◽  
2019 ◽  
Vol 9 (49) ◽  
pp. 28775-28782
Author(s):  
Jun-feng Huo ◽  
Xiao-bing Chen
Keyword(s):  
Dna Damage ◽  
Cell Growth ◽  
Signaling Pathway ◽  
Glioma Cell ◽  
Akt Signaling ◽  
Akt Signaling Pathway ◽  
Tumor Agent

Aclarubicin (ACR), an anthracycline anti-tumor agent, is known to play important roles in cancer.

scholarly journals Aged black garlic extract inhibits HT29 colon cancer cell growth via the PI3K/Akt signaling pathway

2014 ◽  
Vol 2 (2) ◽  
pp. 250-254 ◽  
Author(s):  
MENGHUA DONG ◽  
GUIQING YANG ◽  
HANCHEN LIU ◽  
XIAOXU LIU ◽  
SIXIANG LIN ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cell Growth ◽  
Signaling Pathway ◽  
Cancer Cell ◽  
Akt Signaling ◽  
Colon Cancer Cell ◽  
Akt Signaling Pathway ◽  
Cancer Cell Growth ◽  
Ht29 Colon Cancer Cell ◽  
Aged Black Garlic

scholarly journals LINC02085 Regulates Cell Growth and Inflammatory Response in Rheumatoid Arthritis by Regulating PI3K/ AKT Signaling Pathway

2020 ◽  
Author(s):  
Jianting Wen ◽  
Jian Liu ◽  
Xin Wang ◽  
Jie Wang
Keyword(s):  
Rheumatoid Arthritis ◽  
Cell Growth ◽  
Inflammatory Response ◽  
Signaling Pathway ◽  
Akt Signaling ◽  
Akt Pathway ◽  
Migration And Invasion ◽  
Arthritis Score ◽  
Akt Signaling Pathway ◽  
Primary Fibroblast

Abstract Background: The present study explored the possible functions and the underlying mechanism of long Non-coding RNA LINC02085 in rheumatoid arthritis (RA). Methods: Primary fibroblast-like synoviocytes (FLS) were separated from synovial tissues and was established cell lines, then cultured for subsequent cell experiments by transfecting different vectors. Rat with AA were injected with sh-LINC02085. The progression of AA was explored by measuring arthritis score and histologic analysis. ELISA analysis was employed to detect the levels of inflammatory cytokines. CCK8 assay, migration and invasion assays were used to evaluate the proliferation, migration and invasion abilities of cells, respectively. Besides, the levels of the the PI3K/AKT pathway-related proteins were measured by WB and IF. Results: The expression level of LINC02085 was significant high in patients with RA, and positively associated with clinical indexes. We found that LINC02085 was upregulated in RA -FLS and TNF-αstimulated. And overexpression of LINC02085 could promote proliferation, migration and invasion induced by TNF-α, through upregulating the levels of TNF-αand TNFAIP2 and promoting the activation of PI3K/AKT pathway. Whereas downexpression of LINC02085 received the opposite results. Knockdown of LINC02085 significantly ameliorated the progression of AA reflected by decreased arthritis score and cartilage destruction. Conclusion: The present study revealed that LINC02085 could regulate cell growth and inflammatory response of RA-FLS by activating the PI3K/ AKT signaling pathway, subsequently playing important roles in promoting the occurrence and development of RA.

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