Resveratrol Alleviates Rheumatoid Arthritis via Reducing ROS and Inflammation, Inhibiting MAPK Signaling Pathways, and Suppressing Angiogenesis

2018 ◽  
Vol 66 (49) ◽  
pp. 12953-12960 ◽  
Author(s):  
Guliang Yang ◽  
Chia-Che Chang ◽  
Yiwen Yang ◽  
Li Yuan ◽  
Leishiyuan Xu ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Signaling Pathways ◽  
Mapk Signaling ◽  
Mapk Signaling Pathways

scholarly journals Urban Particulate Matter Enhances ROS/IL-6/COX-II Production by Inhibiting MicroRNA-137 in Synovial Fibroblast of Rheumatoid Arthritis

Cells ◽  
2020 ◽  
Vol 9 (6) ◽  
pp. 1378
Author(s):  
Ming-Horng Tsai ◽  
Miao-Ching Chi ◽  
Jen-Fu Hsu ◽  
I-Ta Lee ◽  
Ko-Ming Lin ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Particulate Matter ◽  
Signaling Pathways ◽  
Synovial Fibroblast ◽  
Mapk Signaling ◽  
Mitogen Activated Protein Kinase ◽  
In Vivo Studies ◽  
Ros Generation ◽  
Inflammatory Pathways ◽  
Mapk Signaling Pathways

Background: Rheumatoid arthritis (RA) has been associated with air pollution, possibly due to the augmentation of inflammatory effects. In this study, we aimed to determine the roles of inflammatory pathways and microRNA involved in the pathogenesis of RA fibroblast-like synoviocytes (FLS) inflammation induced by particulate matter. Methods: The inflammatory mediators, messenger RNAs, microRNAs and their interrelationships were investigated using western blotting, QPCR, ELISA and immunohistochemistry. Results: Particulate matter (PMs) induced an increase in the expression of interleukin-6 (IL-6) and cyclooxygenase-II (COX-II) in RA-FLS and microRNA-137 was found definitely to mediate the inflammatory pathways. PMs-induced generation of reactive oxygen species (ROS) in RA-FLS was attenuated by pretreatment with antioxidants. Nox-dependent ROS generation led to phosphorylation of ERK1/2, p38 and JNK, followed by downregulation of microRNA-137. In vivo studies, the joints of rats exposed to PMs revealed synovial fibroblast inflammation under pathologic examination and the expressions of IL-6 and COX-II were obviously increased. PMs exposure results in activated ROS-mediated mitogen-activated protein kinase (MAPK) signaling pathways and cause increased IL-6 and COX-II through downregulation of hsa-miRNA-137, which lead to inflammation and RA exacerbation. Conclusions: microRNA-137 plays an important role in PMs-induced RA acute exacerbation through MAPK signaling pathways and IL-6/COX-II activation. Targeting these mechanisms can potentially be used to develop new therapeutic strategies and prevention of RA inflammation in the future.

scholarly journals Urolithin A attenuates renal fibrosis by inhibiting TGF-β1/Smad and MAPK signaling pathways

2021 ◽  
Vol 83 ◽  
pp. 104547
Author(s):  
Zhenzhen Cheng ◽  
Jingjing Tu ◽  
Hongpan Zhang ◽  
Yi zhang ◽  
Benhong Zhou
Keyword(s):  
Signaling Pathways ◽  
Renal Fibrosis ◽  
Mapk Signaling ◽  
Urolithin A ◽  
Mapk Signaling Pathways ◽  
Tgf Β1

6-Bromoindirubin-3′-Oxime Suppresses LPS-Induced Inflammation via Inhibition of the TLR4/NF-κB and TLR4/MAPK Signaling Pathways

Inflammation ◽  
2019 ◽  
Vol 42 (6) ◽  
pp. 2192-2204 ◽  
Author(s):  
Chang Liu ◽  
Xin Tang ◽  
Wenjing Zhang ◽  
Guohong Li ◽  
Yingyu Chen ◽  
...  
Keyword(s):  
Signaling Pathways ◽  
Mapk Signaling ◽  
Mapk Signaling Pathways

scholarly journals Computational Modeling of PI3K/AKT and MAPK Signaling Pathways in Melanoma Cancer

PLoS ONE ◽  
2016 ◽  
Vol 11 (3) ◽  
pp. e0152104 ◽  
Author(s):  
Francesco Pappalardo ◽  
Giulia Russo ◽  
Saverio Candido ◽  
Marzio Pennisi ◽  
Salvatore Cavalieri ◽  
...  
Keyword(s):  
Computational Modeling ◽  
Signaling Pathways ◽  
Mapk Signaling ◽  
Melanoma Cancer ◽  
Mapk Signaling Pathways

Gβγ interactions with PH domains and Ras-MAPK signaling pathways

1995 ◽  
Vol 20 (4) ◽  
pp. 151-156 ◽  
Author(s):  
J INGLESE ◽  
W KOCH ◽  
K TOUHARA ◽  
R LEFKOWITZ
Keyword(s):  
Signaling Pathways ◽  
Mapk Signaling ◽  
Ph Domains ◽  
Mapk Signaling Pathways
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