First Food-Derived Peptide Inhibitor of the Protein–Protein Interaction between Gain-of-Function PCSK9D374Y and the Low-Density Lipoprotein Receptor

Giovanni Grazioso; Carlotta Bollati; Jacopo Sgrignani; Anna Arnoldi; Carmen Lammi

doi:10.1021/acs.jafc.8b03233

First Food-Derived Peptide Inhibitor of the Protein–Protein Interaction between Gain-of-Function PCSK9D374Y and the Low-Density Lipoprotein Receptor

Journal of Agricultural and Food Chemistry ◽

10.1021/acs.jafc.8b03233 ◽

2018 ◽

Vol 66 (40) ◽

pp. 10552-10557 ◽

Cited By ~ 9

Author(s):

Giovanni Grazioso ◽

Carlotta Bollati ◽

Jacopo Sgrignani ◽

Anna Arnoldi ◽

Carmen Lammi

Keyword(s):

Protein Interaction ◽

Low Density Lipoprotein ◽

Density Lipoprotein ◽

Peptide Inhibitor ◽

Low Density ◽

Lipoprotein Receptor ◽

Gain Of Function ◽

Low Density Lipoprotein Receptor ◽

Protein Protein Interaction ◽

Density Lipoprotein Receptor

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Lupin Peptides Modulate the Protein-Protein Interaction of PCSK9 with the Low Density Lipoprotein Receptor in HepG2 Cells

Scientific Reports ◽

10.1038/srep29931 ◽

2016 ◽

Vol 6 (1) ◽

Cited By ~ 37

Author(s):

Carmen Lammi ◽

Chiara Zanoni ◽

Gilda Aiello ◽

Anna Arnoldi ◽

Giovanni Grazioso

Keyword(s):

Protein Interaction ◽

Hepg2 Cells ◽

Low Density Lipoprotein ◽

Density Lipoprotein ◽

Low Density ◽

Lipoprotein Receptor ◽

Low Density Lipoprotein Receptor ◽

Protein Protein Interaction ◽

Density Lipoprotein Receptor

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Apolipoprotein E-low density lipoprotein receptor binding: Study of protein-protein interaction in rationally selected docked complexes

Proteins Structure Function and Bioinformatics ◽

10.1002/prot.20080 ◽

2004 ◽

Vol 55 (4) ◽

pp. 874-884 ◽

Cited By ~ 15

Author(s):

Martine Prévost ◽

Vincent Raussens

Keyword(s):

Apolipoprotein E ◽

Receptor Binding ◽

Protein Interaction ◽

Low Density Lipoprotein ◽

Density Lipoprotein ◽

Binding Study ◽

Low Density ◽

Lipoprotein Receptor ◽

Protein Protein Interaction ◽

Density Lipoprotein Receptor

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518-P: Involvement of Low-Density Lipoprotein Receptor-Related Protein 5 in Chronic Kidney Diseases via Modulation of TGF-β-Smad2/3 Signaling

Diabetes ◽

10.2337/db19-518-p ◽

2019 ◽

Vol 68 (Supplement 1) ◽

pp. 518-P

Author(s):

XUEMIN HE ◽

RUI CHENG ◽

CHAO HUANG ◽

YANMING CHEN ◽

JIAN-XING MA

Keyword(s):

Kidney Diseases ◽

Low Density Lipoprotein ◽

Density Lipoprotein ◽

Low Density ◽

Lipoprotein Receptor ◽

Related Protein ◽

Low Density Lipoprotein Receptor ◽

Chronic Kidney Diseases ◽

Density Lipoprotein Receptor ◽

Lipoprotein Receptor Related Protein

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Phenotypic presentation of the FH-Cincinnati type 5 low density lipoprotein receptor mutation

Scandinavian Journal of Clinical and Laboratory Investigation ◽

10.3109/00365519609088591 ◽

1996 ◽

Vol 56 (1) ◽

pp. 75-85 ◽

Cited By ~ 2

Author(s):

H. Nissen ◽

A. B. Hansen ◽

P. Guldberg ◽

N. E. Petersen ◽

M. L. Larsen ◽

...

Keyword(s):

Low Density Lipoprotein ◽

Density Lipoprotein ◽

Low Density ◽

Lipoprotein Receptor ◽

Low Density Lipoprotein Receptor ◽

Density Lipoprotein Receptor

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Faculty Opinions recommendation of Low-density lipoprotein receptor-related protein 5 governs Wnt-mediated osteoarthritic cartilage destruction.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.718258241.793492848 ◽

2014 ◽

Author(s):

Yefu Li ◽

Lin Xu

Keyword(s):

Low Density Lipoprotein ◽

Density Lipoprotein ◽

Cartilage Destruction ◽

Low Density ◽

Lipoprotein Receptor ◽

Related Protein ◽

Low Density Lipoprotein Receptor ◽

Osteoarthritic Cartilage ◽

Density Lipoprotein Receptor ◽

Lipoprotein Receptor Related Protein

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Faculty Opinions recommendation of Autoantibodies to low-density lipoprotein receptor-related protein 4 in myasthenia gravis.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.9232956.9826054 ◽

2011 ◽

Author(s):

Steven Burden

Keyword(s):

Myasthenia Gravis ◽

Low Density Lipoprotein ◽

Density Lipoprotein ◽

Low Density ◽

Lipoprotein Receptor ◽

Related Protein ◽

Low Density Lipoprotein Receptor ◽

Density Lipoprotein Receptor ◽

Lipoprotein Receptor Related Protein

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Hypoxia Could Induce Endoplasmic-Reticulum Stress by Regulating the Expression of β-Catenin Via Low-Density Lipoprotein Receptor-Related Protein 6 Pathway

SSRN Electronic Journal ◽

10.2139/ssrn.3289784 ◽

2018 ◽

Author(s):

Yanlei Ma ◽

Ting Liu ◽

Xiaomei Li ◽

Chao Lei ◽

Jinsheng Weng ◽

...

Keyword(s):

Endoplasmic Reticulum ◽

Endoplasmic Reticulum Stress ◽

Low Density Lipoprotein ◽

Density Lipoprotein ◽

Low Density ◽

Lipoprotein Receptor ◽

Related Protein ◽

Low Density Lipoprotein Receptor ◽

Density Lipoprotein Receptor ◽

Lipoprotein Receptor Related Protein

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NPXY, a sequence often found in cytoplasmic tails, is required for coated pit-mediated internalization of the low density lipoprotein receptor.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(19)39742-x ◽

1990 ◽

Vol 265 (6) ◽

pp. 3116-3123 ◽

Cited By ~ 4

Author(s):

W J Chen ◽

J L Goldstein ◽

M S Brown

Keyword(s):

Low Density Lipoprotein ◽

Density Lipoprotein ◽

Low Density ◽

Lipoprotein Receptor ◽

Low Density Lipoprotein Receptor ◽

Cytoplasmic Tails ◽

Density Lipoprotein Receptor

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The Low Density Lipoprotein Receptor-related Protein Functions as an Endocytic Receptor for Decorin

Journal of Biological Chemistry ◽

10.1016/s0021-9258(19)84070-x ◽

2006 ◽

Vol 281 (42) ◽

pp. 31562-31571

Author(s):

Enrique Brandan ◽

Claudio Retamal ◽

Claudio Cabello-Verrugio ◽

Mari´a-Paz Marzolo

Keyword(s):

Low Density Lipoprotein ◽

Density Lipoprotein ◽

Low Density ◽

Lipoprotein Receptor ◽

Related Protein ◽

Low Density Lipoprotein Receptor ◽

Density Lipoprotein Receptor ◽

Protein Functions ◽

Lipoprotein Receptor Related Protein

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Regulation of low density lipoprotein receptor gene expression in HepG2 and Caco2 cells by palmitate, oleate, and 25-hydroxycholesterol

The Journal of Lipid Research ◽

10.1016/s0022-2275(20)39730-3 ◽

1995 ◽

Vol 36 (7) ◽

pp. 1434-1446

Author(s):

R A Srivastava ◽

H Ito ◽

M Hess ◽

N Srivastava ◽

G Schonfeld

Keyword(s):

Gene Expression ◽

Receptor Gene ◽

Low Density Lipoprotein ◽

Density Lipoprotein ◽

Low Density ◽

Lipoprotein Receptor ◽

Low Density Lipoprotein Receptor ◽

Caco2 Cells ◽

Density Lipoprotein Receptor ◽

Receptor Gene Expression

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