Lipid–Polymer Hybrid Nanoparticles for Oral Delivery of Tartary Buckwheat Flavonoids

2018 ◽  
Vol 66 (19) ◽  
pp. 4923-4932 ◽  
Author(s):  
Jinming Zhang ◽  
Di Wang ◽  
Yihan Wu ◽  
Wei Li ◽  
Yichen Hu ◽  
...  
Keyword(s):  
Oral Delivery ◽  
Tartary Buckwheat ◽  
Hybrid Nanoparticles ◽  
Polymer Hybrid

scholarly journals Development of Lipid–Polymer Hybrid Nanoparticles for Improving Oral Absorption of Enoxaparin

Pharmaceutics ◽  
2020 ◽  
Vol 12 (7) ◽  
pp. 607
Author(s):  
Bo Tang ◽  
Yu Qian ◽  
Guihua Fang
Keyword(s):  
Oral Delivery ◽  
Encapsulation Efficiency ◽  
Oral Absorption ◽  
Poloxamer 407 ◽  
Hybrid Nanoparticles ◽  
Polymer Hybrid ◽  
Study Results ◽  
Confocal Scanning

Enoxaparin, an anticoagulant that helps prevent the formation of blood clots, is administered parenterally. Here, we report the development and evaluation of lipid–polymer hybrid nanoparticles (LPHNs) for the oral delivery of enoxaparin. The polymer poloxamer 407 (P407) was incorporated into lipid nanoparticles to form gel cores and ensure high encapsulation efficiency and the controlled release of enoxaparin. In vitro results indicated that 30% of P407 incorporation offered higher encapsulation efficiency and sustained the release of enoxaparin. Laser confocal scanning microscopy (LCSM) images showed that LPHNs could not only significantly improve the accumulation of enoxaparin in intestinal villi but also facilitate enoxaparin transport into the underlayer of intestinal epithelial cells. In vivo pharmacokinetic study results indicated that the oral bioavailability of enoxaparin was markedly increased about 6.8-fold by LPHNs. In addition, its therapeutic efficacy against pulmonary thromboembolism was improved 2.99-fold by LPHNs. Moreover, LPHNs exhibited excellent biocompatibility in the intestine. Overall, the LPHN is a promising delivery carrier to boost the oral absorption of enoxaparin.

Mucosal transfer of wheat germ agglutinin modified lipid–polymer hybrid nanoparticles for oral delivery of oridonin

2017 ◽  
Vol 13 (7) ◽  
pp. 2219-2229 ◽  
Author(s):  
Ying Liu ◽  
Jinguang Liu ◽  
Jun Liang ◽  
Meiying Zhang ◽  
Zhe Li ◽  
...  
Keyword(s):  
Wheat Germ Agglutinin ◽  
Oral Delivery ◽  
Wheat Germ ◽  
Hybrid Nanoparticles ◽  
Polymer Hybrid

Wheat germ agglutinin modification of lipid–polymer hybrid nanoparticles: enhanced cellular uptake and bioadhesion

RSC Advances ◽  
2016 ◽  
Vol 6 (42) ◽  
pp. 36125-36135 ◽  
Author(s):  
Ying Liu ◽  
Yiqing Zhao ◽  
Jinguang Liu ◽  
Meiying Zhang ◽  
Minglei Yu ◽  
...  
Keyword(s):  
Cellular Uptake ◽  
Wheat Germ Agglutinin ◽  
Oral Delivery ◽  
Wheat Germ ◽  
Water Soluble ◽  
Hybrid Nanoparticles ◽  
Poorly Water Soluble Drugs ◽  
Polymer Hybrid ◽  
Water Soluble Drugs ◽  
Poorly Water Soluble

WGA-modified lipid–polymer hybrid nanoparticles (WGA-LPNs) showed increased intestinal bioadhesion and cellular uptake and have the potential to improve the oral delivery of poorly water-soluble drugs.

Improved oral delivery of tilianin through lipid–polymer hybrid nanoparticles to enhance bioavailability

2019 ◽  
Vol 519 (2) ◽  
pp. 316-322 ◽  
Author(s):  
Cheng Zeng ◽  
Ruifang Zheng ◽  
Xiaoyi Yang ◽  
Yanwen Du ◽  
Jianguo Xing ◽  
...  
Keyword(s):  
Oral Delivery ◽  
Hybrid Nanoparticles ◽  
Polymer Hybrid

Solid Lipid–Polymer Hybrid Nanoparticles by In Situ Conjugation for Oral Delivery of Astaxanthin

2018 ◽  
Vol 66 (36) ◽  
pp. 9473-9480 ◽  
Author(s):  
Taoran Wang ◽  
Qiaobin Hu ◽  
Ji-Young Lee ◽  
Yangchao Luo
Keyword(s):  
Oral Delivery ◽  
Hybrid Nanoparticles ◽  
Solid Lipid ◽  
Polymer Hybrid

Lipid-polymer hybrid nanoparticles: Synthesis strategies and biomedical applications

2019 ◽  
Vol 160 ◽  
pp. 130-142 ◽  
Author(s):  
Vivek Dave ◽  
Kajal Tak ◽  
Amit Sohgaura ◽  
Ashish Gupta ◽  
Veera Sadhu ◽  
...  
Keyword(s):  
Biomedical Applications ◽  
Hybrid Nanoparticles ◽  
Polymer Hybrid ◽  
Nanoparticles Synthesis
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