Caffeic Acid Phenethyl Ester (Propolis Extract) Ameliorates Insulin Resistance by Inhibiting JNK and NF-κB Inflammatory Pathways in Diabetic Mice and HepG2 Cell Models

2017 ◽  
Vol 65 (41) ◽  
pp. 9041-9053 ◽  
Author(s):  
Jiarui Nie ◽  
Yaning Chang ◽  
Yujia Li ◽  
Yingjun Zhou ◽  
Jiawen Qin ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Caffeic Acid ◽  
Hepg2 Cell ◽  
Caffeic Acid Phenethyl Ester ◽  
Diabetic Mice ◽  
Cell Models ◽  
Propolis Extract ◽  
Inflammatory Pathways

scholarly journals Caffeic Acid Phenethyl Ester Protects against Amphotericin B Induced Nephrotoxicity in Rat Model

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Atila Altuntaş ◽  
H. Ramazan Yılmaz ◽  
Ayşegül Altuntaş ◽  
Efkan Uz ◽  
Murat Demir ◽  
...  
Keyword(s):  
Caffeic Acid ◽  
Amphotericin B ◽  
Left Kidney ◽  
Caffeic Acid Phenethyl Ester ◽  
Control Group ◽  
Albino Rats ◽  
Sod Activity ◽  
Rat Models ◽  
Propolis Extract ◽  
The Right

The present study was conducted to investigate whether caffeic acid phenethyl ester (CAPE), an active component of propolis extract, has a protective effect on amphotericin B induced nephrotoxicity in rat models. Male Wistar-Albino rats were randomly divided into four groups: (I) control group (n = 10), (II) CAPE group (n = 9) which received 10 μmol/kg CAPE intraperitoneally (i.p.), (III) amphotericin B group (n = 7) which received one dose of 50 mg/kg amphotericin B, and (IV) amphotericin B plus CAPE group (n = 7) which received 10 μmol/kg CAPE i.p. and one dose of 50 mg/kg amphotericin B. The left kidney was evaluated histopathologically for nephrotoxicity. Levels of malondialdehyde (MDA), nitric oxide (NO), enzyme activities including catalase (CAT), and superoxide dismutase (SOD) were measured in the right kidney. Histopathological damage was prominent in the amphotericin B group compared to controls, and the severity of damage was lowered by CAPE administration. The activity of SOD, MDA, and NO levels increased and catalase activity decreased in the amphotericin B group compared to the control group (P=0.0001,P=0.003,P=0.0001, andP=0.0001, resp.). Amphotericin B plus CAPE treatment caused a significant decrease in MDA, NO levels, and SOD activity (P=0.04,P=0.02, andP=0.0001, resp.) and caused an increase in CAT activity compared with amphotericin B treatment alone (P=0.005). CAPE treatment seems to be an effective adjuvant agent for the prevention of amphotericin B nephrotoxicity in rat models.

Effect of a propolis extract and caffeic acid phenethyl ester on formation of aberrant crypt foci and tumors in the rat colon

Fitoterapia ◽  
2002 ◽  
Vol 73 ◽  
pp. S38-S43 ◽  
Author(s):  
F. Borrelli ◽  
A.A. Izzo ◽  
G. Di Carlo ◽  
P. Maffia ◽  
A. Russo ◽  
...  
Keyword(s):  
Caffeic Acid ◽  
Caffeic Acid Phenethyl Ester ◽  
Aberrant Crypt Foci ◽  
Rat Colon ◽  
Propolis Extract

CAPE (caffeic acid phenethyl ester)-based propolis extract (Bio 30) suppresses the growth of human neurofibromatosis (NF) tumor xenografts in mice

2009 ◽  
Vol 23 (2) ◽  
pp. 226-230 ◽  
Author(s):  
M. Demestre ◽  
S. M. Messerli ◽  
N. Celli ◽  
M. Shahhossini ◽  
L. Kluwe ◽  
...  
Keyword(s):  
Caffeic Acid ◽  
Caffeic Acid Phenethyl Ester ◽  
Tumor Xenografts ◽  
Propolis Extract

scholarly journals Development and Application of an LC-MS/MS Method for Identification of Polyphenols in Propolis Extract

Proceedings ◽  
2020 ◽  
Vol 55 (1) ◽  
pp. 10
Author(s):  
Madalina Maria Nichitoi ◽  
Teodor Costache ◽  
Ana Maria Josceanu ◽  
Raluca Isopescu ◽  
Gabriela Isopencu ◽  
...  
Keyword(s):  
Ferulic Acid ◽  
Gallic Acid ◽  
Caffeic Acid ◽  
Caffeic Acid Phenethyl Ester ◽  
Polyphenolic Compounds ◽  
Coumaric Acid ◽  
Propolis Extract

: We identified and quantified by LC-MS/MS 11 (quercetin, galangin, pinocembrin, kaempferol, vanillin, chrysin, gallic acid, p-coumaric acid, trans-ferulic acid, caffeic acid, and caffeic acid phenethyl ester) out of the 21 polyphenolic compounds we looked for in ethanolic (25% and 50%) and aqueous propolis extracts by comparison with standards and literature data.

scholarly journals Caffeic Acid Phenethyl Ester and Therapeutic Potentials

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Ghulam Murtaza ◽  
Sabiha Karim ◽  
Muhammad Rouf Akram ◽  
Shujaat Ali Khan ◽  
Saira Azhar ◽  
...  
Keyword(s):  
Caffeic Acid ◽  
Therapeutic Efficacy ◽  
Literature Search ◽  
Bioactive Compound ◽  
Caffeic Acid Phenethyl Ester ◽  
Review Article ◽  
Therapeutic Effects ◽  
Propolis Extract ◽  
Principal Objective ◽  
Existing Data

Caffeic acid phenethyl ester (CAPE) is a bioactive compound of propolis extract. The literature search elaborates that CAPE possesses antimicrobial, antioxidant, anti-inflammatory, and cytotoxic properties. The principal objective of this review article is to sum up and critically assess the existing data about therapeutic effects of CAPE in different disorders. The findings elaborate that CAPE is a versatile therapeutically active polyphenol and an effective adjuvant of chemotherapy for enhancing therapeutic efficacy and diminishing chemotherapy-induced toxicities.

scholarly journals Caffeic Acid Esters Affect Intracellular Oxidation and Vitality of Yeast Saccharomyces cerevisiae Cells

2017 ◽  
Vol 12 (11) ◽  
pp. 1934578X1701201
Author(s):  
Tanja Petelinc ◽  
Manca Medved ◽  
Tomaž Polak ◽  
Polona Jamnik
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Caffeic Acid ◽  
Caffeic Acid Phenethyl Ester ◽  
Isopropyl Ester ◽  
Cellular Viability ◽  
Yeast Saccharomyces Cerevisiae ◽  
Propolis Extract ◽  
Eukaryotic Organism ◽  
Caffeic Acid Esters ◽  
Acid Esters

The effect of four esters of caffeic acid, caffeic acid methanol ester (CAME), caffeic acid ethanol ester (CAEE), caffeic acid isopropyl ester (CAIPE) and caffeic acid phenethyl ester (CAPE) on intracellular oxidation, vitality and viability of the yeast Saccharomyces cerevisiae as a model eukaryotic organism was investigated. Results showed that each ester showed its own behavior at the concentrations tested. For CAPE, CAIPE and CAEE decreased intracellular oxidation and simultaneously increased cellular vitality with no changes in cellular viability compared to the control were determined. Additionally, a combination of CAIPE or CAPE with ethanolic propolis extract was observed to be more effective in decreasing intracellular oxidation compared to propolis extract alone.

Novel Caffeic Acid Phenethyl Ester (Cape) Analogues as Inducers of Heme Oxygenase-1

2017 ◽  
Vol 23 (18) ◽  
Author(s):  
Valeria Pittala ◽  
Luca Vanella ◽  
Loredana Salerno ◽  
Claudia Di Giacomo ◽  
Rosaria Acquaviva ◽  
...  
Keyword(s):  
Caffeic Acid ◽  
Heme Oxygenase ◽  
Caffeic Acid Phenethyl Ester ◽  
Heme Oxygenase 1

scholarly journals Determination of antioxidant activity and phenolic compounds for basic standardization of Turkish propolis

2021 ◽  
Vol 64 (1) ◽  
Author(s):  
Aslı Özkök ◽  
Merve Keskin ◽  
Aslı Elif Tanuğur Samancı ◽  
Elif Yorulmaz Önder ◽  
Çiğdem Takma
Keyword(s):  
Antioxidant Capacity ◽  
Caffeic Acid ◽  
Caffeic Acid Phenethyl Ester ◽  
Total Phenolic ◽  
Scaling Analysis ◽  
Flavonoid Content ◽  
Multidimensional Scaling Analysis ◽  
Flavonoid Quercetin ◽  
Phenolic And Flavonoid

AbstractThis study aimed to determine the standard amount of antioxidant content and compounds of the propolis for the standardization of propolis. For this purpose, the total flavonoids, total phenolic, CUPRAC antioxidant capacity content and the diversity of phenolic and flavonoid components of these propolis samples were found by HPLC determined at the 23 propolis samples which were collected different regions of Turkey. Beside that, the similarities and differences of these 23 provinces to each other according to their antioxidant capacities were investigated by multidimensional scaling analysis. The total flavonoid content in the propolis samples were determined between 21.28 and 152.56 mg CE/g. The total phenolic content in the propolis samples was found between 34.53 mg and 259.4 mg GAE/g. CUPRAC antioxidant capacity of the propolis samples and antioxidant range was found from 95.35 to 710.43 mg TE/g. Also, 4 flavonoid [Quercetin (min.1.12–max.4.14 mg/g), Galangin (min.0.72–max.40.79 mg/g), Apigenin (min.1.07–max.17.35 mg/g), Pinocembrin (min.1.32–max.39.92 mg/g] and 6 phenolic acid [Caffeic acid (min.1.20–max.7.6 mg/g), p-Coumaric acid (min.1.26–max.4.47 mg/g), trans-Ferulic acid (min.1.28–max.4.92 mg/g), Protocatechuic acid (1.78 mg/g), trans-Cinnamic acid (min.1.05–max.3.83 mg/g), Caffeic Acid Phenethyl Ester (CAPE) (min.1.41–max.30.15 mg/g)] components were detected as mg/g, in different ratios in propolis samples collected from different regions. The feature of this study, so far, is to have the maximum number of samples representing the Turkish propolis, and so is thought to help to national and international propolis standard workings.

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