Long-Term Effect of a Leonardite Iron Humate Improving Fe Nutrition As Revealed in Silico, in Vivo, and in Field Experiments

2017 ◽  
Vol 65 (31) ◽  
pp. 6554-6563 ◽  
Author(s):  
María T. Cieschi ◽  
Marcos Caballero-Molada ◽  
Nieves Menéndez ◽  
Miguel A. Naranjo ◽  
Juan J. Lucena
Keyword(s):  
In Silico ◽  
Field Experiments ◽  
Term Effect ◽  
Long Term Effect ◽  
Fe Nutrition

scholarly journals Long-term Effect of Silver Powder in vivo

2008 ◽  
Vol 27 (4) ◽  
pp. 612-625 ◽  
Author(s):  
Hidekazu AOYAGI ◽  
Shin-ich IWASAKI
Keyword(s):  
Silver Powder ◽  
Term Effect ◽  
Long Term Effect

Long-term effect of glucocorticoid on connective tissue of aorta and skin Morphological and biochemical studies of tissues from rabbits with intact and injured aortas

1980 ◽  
Vol 95 (2) ◽  
pp. 271-281 ◽  
Author(s):  
R. Manthorpe ◽  
C. Garbarsch ◽  
I. Lorenzen
Keyword(s):  
Connective Tissue ◽  
Amino Nitrogen ◽  
Vascular Wall ◽  
Term Effect ◽  
Intact Skin ◽  
Long Term Effect ◽  
Biochemical Analyses

Abstract. The long-term effect of prednisolone — 0.6 mg/day for 63 days — upon mechanically induced inflammation and repair processes in vascular connective tissue was compared with that upon undamaged vascular wall and intact skin of rabbits. The investigations included histological examination of aorta as well as biochemical analyses of collagen and various glycosaminoglycan fractions, RNA, DNA and alpha-amino nitrogen. The metabolism of collagen was estimated by in vitro labelling with [14C]proline and the metabolism of glycosaminoglycans by in vivo labelling with [35S]O4. The radioactivity of [125I]albumin in the aorta and serum was also studied. The collagen, glycosaminoglycans, RNA, DNA and water of vascular connective tissue during inflammation and repair and of intact skin was found to be more sensitive to the action of prednisolone than the connective tissue of undamaged vascular wall. An increased degradation of newly synthesized collagen was observed in damaged aorta as well as in skin in which also the biosynthesis of collagen was inhibited. Prednisolone inhibited the biosynthesis of glycosaminoglycans and decreased the total amount of glycosaminoglycans and of nucleic acids in the damaged aortas and the skin. The [125I]albumin aorta-to-serum ratio was significantly increased in the damaged aorta. Prednisolone treatment decreased the ratio in injured aortas, but elevated the ratio in the undamaged vessels. Prednisolone inhibited intimal thickening of the injured aortas.

scholarly journals Long-term assessment of airborne radiocesium after the Fukushima nuclear accident: re-suspension from bare soil and forest ecosystems

2016 ◽  
Vol 16 (20) ◽  
pp. 13149-13172 ◽  
Author(s):  
Mizuo Kajino ◽  
Masahide Ishizuka ◽  
Yasuhito Igarashi ◽  
Kazuyuki Kita ◽  
Chisato Yoshikawa ◽  
...  
Keyword(s):  
Forest Ecosystems ◽  
Field Experiments ◽  
Dust Emission ◽  
Term Effect ◽  
Nuclear Accident ◽  
Fukushima Nuclear Accident ◽  
Air Concentration ◽  
Long Term Effect ◽  
Contaminated Area

Abstract. The long-term effect of 137Cs re-suspension from contaminated soil and forests due to the Fukushima nuclear accident has been quantitatively assessed by numerical simulation, a field experiment on dust emission flux in a contaminated area (town of Namie, Fukushima prefecture), and air concentration measurements inside (Namie) and outside (city of Tsukuba, Ibaraki prefecture) the contaminated area. In order to assess the long-term effect, the full year of 2013 was selected to study just after the start of the field experiments. The 137Cs concentrations at Namie and Tsukuba were approximately 10−1–1 and 10−2–10−1 mBq m−3, respectively. The observed monthly median concentration at Namie was 1 to 2 orders of magnitude larger than that at Tsukuba. This observed difference between the two sites was consistent with the simulated difference, indicating successful modeling of 137Cs re-suspension and atmospheric transport. The estimated re-suspension rate was approximately 10−6 day−1, which was significantly lower than the decreasing rate of the ambient gamma dose rate in Fukushima prefecture (10−4–10−3 day−1) as a result of radioactive decay, migration in the soil and biota, and decontamination. Consequently, re-suspension contributed negligibly in reducing ground radioactivity. The dust emission model could reproduce the air concentration of 137Cs in winter, whereas the summer air concentration was underestimated by 1 to 2 orders of magnitude. Re-suspension from forests at a constant rate of 10−7 h−1, multiplied by the green area fraction, could explain the air concentration of 137Cs at Namie and its seasonal variation. The simulated contribution of dust re-suspension to the air concentration was 0.7–0.9 in the cold season and 0.2–0.4 in the warm season at both sites; the remainder of the contribution was re-suspension from forest. The re-suspension mechanisms, especially through the forest ecosystems, remain unknown. This is the first study that provides a crude estimation of the long-term assessment of radiocesium re-suspension. Additional research activities should investigate the processes/mechanisms governing the re-suspension over the long term. This could be achieved through conducting additional field experiments and numerical simulations.

scholarly journals Long Term Evaluation of Biodegradation and Biocompatibility In-Vivo the Mg-0.5Ca-xZr Alloys in Rats

Crystals ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. 54
Author(s):  
Eusebiu-Viorel Sindilar ◽  
Corneliu Munteanu ◽  
Sorin Aurelian Pasca ◽  
Iuliana Mihai ◽  
Madalina Elena Henea ◽  
...  
Keyword(s):  
Bone Fractures ◽  
Tissue Reaction ◽  
Term Effect ◽  
Metallic Materials ◽  
Long Term Effect ◽  
Term Evaluation ◽  
Laboratory Examinations ◽  
Over Time

Biodegradable alloys in Mg have the advantages of traditional metallic materials and those of biodegradable polymers with superior strength, lower density and ideal rigidity for fixing bone fractures. The biocompatibility and biodegradability of the five concentrations of Mg-0.5Ca-xZr alloys used were assessed using clinical and laboratory examinations that followed over time: tissue reaction, histological and imaging (RX, CT and SEM) evolution at 1, 2, 4 and 8 weeks after implant. The main purpose of this study was to investigate in vivo the long-term effect of Mg-0.5Ca-xZr alloys in rats. The results confirmed that Mg-0.5Ca-xZr alloys are biocompatible and biodegradable and are recommended to be used as possible materials for new orthopedics devices.

Curcumin Modulates Glycolytic Metabolism and Inflammatory Cytokines via Nrf 2 in Dalton’s Lymphoma Ascites Cells In Vivo

2019 ◽  
Vol 18 (12) ◽  
pp. 1779-1791 ◽  
Author(s):  
Laxmidhar Das ◽  
Manjula Vinayak
Keyword(s):  
Proinflammatory Cytokines ◽  
Term Effect ◽  
Glycolytic Metabolism ◽  
Antioxidant Defence ◽  
Long Term Effect ◽  
Antioxidant Defence System ◽  
Dalton’S Lymphoma ◽  
Dalton's Lymphoma

Background: Warburg effect is characterized by the upregulation of HIF-1 and c-Myc regulated LDH-A, even aerobically owing to hypoxic environment and alterations in oncogenes or tumor suppressor genes in cancer. Reduced antioxidant defence system in transformed cells favors higher ROS production, which plays a significant role in carcinogenesis and acts as an important regulator of NF-κB. In addition, various proinflammatory cytokines play active roles in maintenance and progression of cancer. Objective: In continuation with our previous studies illustrating the long-term effect of curcumin using a liver tissue, present study was aimed to elucidate the anti-cancer effect of curcumin due to its long-term effect in the regulation of glycolytic metabolism, NF-κB activation, expression of proinflammatory cytokines in Dalton’s lymphoma ascites cells in vivo. Method: Spectrophotometric assays, RT-PCR and EMSA were performed to address the problems. Results: Results revealed that curcumin-induced activation of antioxidant enzymes, Nrf2 and downstream signaling gene NQO1. Reduction of oxidative stress, down-regulation of NADPH: Oxidase, decline in ROS and H2O2 levels were also observed. Activation of NF-κB, expression of COX2, HIF-1α and cMyc, as well as expression and activity of LDH-A were significantly reduced by curcumin. Besides, expression of proinflammatory cytokines was significantly down-regulated via reducing binding of nuclear protein with AP-1, NF-IL6, ETS and NF-κB binding elements of IL-1α, IL-1β, TNF-α and IL-6 promoters, respectively. Conclusion: Curcumin downregulates glycolytic metabolism via modulation of stress-activated genes and reduces oxidative stress by enhancing antioxidant defence system, which inhibits activation of NF-κB signaling and expression of proinflammatory cytokines in Dalton’s lymphoma ascites cells in vivo.

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