Long Chain Alkyl Esters of Hydroxycinnamic Acids as Promising Anticancer Agents: Selective Induction of Apoptosis in Cancer Cells

2017 ◽  
Vol 65 (33) ◽  
pp. 7228-7239 ◽  
Author(s):  
José C. J. M. D. S. Menezes ◽  
Najmeh Edraki ◽  
Shrivallabh P. Kamat ◽  
Mahsima Khoshneviszadeh ◽  
Zahra Kayani ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Anticancer Agents ◽  
Hydroxycinnamic Acids ◽  
Alkyl Esters ◽  
Induction Of Apoptosis ◽  
Long Chain ◽  
Apoptosis In Cancer Cells

Efficient induction of apoptosis in cancer cells by paclitaxel-loaded selenium nanoparticles

Nanomedicine ◽  
2017 ◽  
Vol 12 (21) ◽  
pp. 2641-2651 ◽  
Author(s):  
Anil Parsram Bidkar ◽  
Pallab Sanpui ◽  
Siddhartha Sankar Ghosh
Keyword(s):  
Cancer Cells ◽  
Selenium Nanoparticles ◽  
Efficient Induction ◽  
Induction Of Apoptosis ◽  
Apoptosis In Cancer Cells

Induction of apoptosis in cancer cells by p-coumarate ester derivatives

2016 ◽  
Vol 61 ◽  
pp. S135
Author(s):  
O. Firuzi ◽  
F. Borges ◽  
J.C. Menezes ◽  
N. Edraki ◽  
S. Kamat ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Induction Of Apoptosis ◽  
Apoptosis In Cancer Cells

scholarly journals Poly(I:C) induces intense expression of c-IAP2 and cooperates with an IAP inhibitor in induction of apoptosis in cancer cells

BMC Cancer ◽  
2010 ◽  
Vol 10 (1) ◽  
Author(s):  
Luc Friboulet ◽  
Claire Gourzones ◽  
Sai Wah Tsao ◽  
Yannis Morel ◽  
Carine Paturel ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Poly I:C ◽  
Induction Of Apoptosis ◽  
Apoptosis In Cancer Cells

Long chain alkyl esters of 4′-hydroxycinnamic acids from leaves of Rosa rugosa

1992 ◽  
Vol 31 (9) ◽  
pp. 3282-3283 ◽  
Author(s):  
Yasuyuki Hashidoko ◽  
Satoshi Tahara ◽  
Junya Mizutani
Keyword(s):  
Hydroxycinnamic Acids ◽  
Alkyl Esters ◽  
Rosa Rugosa ◽  
Long Chain

scholarly journals Anticancer Activity of Some Ruthenium (III) Complexes with Quinolone Antibiotics: In Vitro Cytotoxicity, Cell Cycle Modulation, and Apoptosis-Inducing Properties in LoVo Colon Cancer Cell Line

2021 ◽  
Vol 11 (18) ◽  
pp. 8594
Author(s):  
Mirela Mihaila ◽  
Camelia Mia Hotnog ◽  
Marinela Bostan ◽  
Alexandra Cristina Munteanu ◽  
Ileana Adela Vacaroiu ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Colon Cancer ◽  
Cell Proliferation ◽  
Anticancer Activity ◽  
Cancer Cells ◽  
Anticancer Agents ◽  
Cycle Phase ◽  
Quinolone Antibiotics ◽  
Induction Of Apoptosis ◽  
Cell Cycle Phases

Cisplatin is one of the most effective anticancer agents used to treat colon cancer, which is the third malignancy between the most common human cancers in the world, but the resistance developed represents an obstacle against the full success of chemotherapy. An emerging interest appeared in finding other metallic compounds, such as ruthenium(III) complexes, for chemotherapeutic application in cancer. Our study focused on the anticancer activity of several ruthenium (Ru) complexes with quinolone antibiotics in colon tumor cell cultures. Real-time cell analysis and drug-mediated cytotoxicity tests monitored the inhibitory effects in the drug-treated LoVo colon cancer cells. Flow cytometry assays were performed to evaluate cell cycle phases distribution and apoptotic events. The obtained results showed dose-dependent increased levels of cell lysis and induction of apoptosis in LoVo cancer cells treated with the Ru(III) complexes. In addition, data showed a major decrease in cell proliferation, since the percentages of cells distributed in the S cell cycle phase diminished, and a G0/G1 cell arrest was observed. Therefore, our results strongly suggest that the newly synthesized Ru(III) complexes might play an important role in future chemotherapeutic approaches, since their activity is based on diminishing cell proliferation, induction of apoptosis, and modulation of cell cycle phases.

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