scholarly journals Structure of the Major Apple Allergen Mal d 1

2017 ◽  
Vol 65 (8) ◽  
pp. 1606-1612 ◽  
Author(s):  
Linda Ahammer ◽  
Sarina Grutsch ◽  
Anna S. Kamenik ◽  
Klaus R. Liedl ◽  
Martin Tollinger
Keyword(s):  
Mal D 1

scholarly journals Relationship between Phenolic Compounds, Antioxidant Properties, and the Allergenic Protein Mal d 1 in Different Selenium-Biofortified Apple Cultivars (Malus domestica)

Molecules ◽  
2021 ◽  
Vol 26 (9) ◽  
pp. 2647
Author(s):  
Sabrina Groth ◽  
Christoph Budke ◽  
Timo Weber ◽  
Susanne Neugart ◽  
Sven Brockmann ◽  
...  
Keyword(s):  
Phenolic Compounds ◽  
Antioxidant Properties ◽  
Total Phenolic ◽  
Allergenic Protein ◽  
Antibody Recognition ◽  
Allergenic Potential ◽  
Allergenic Proteins ◽  
Other Substances ◽  
Mal D 1 ◽  
Apple Cultivars

Notable parts of the population in Europe suffer from allergies towards apples. To address this health problem, the analysis of the interactions of relevant allergens with other substances such as phenolic compounds is of particular importance. The aim of this study was to evaluate the correlations between the total phenolic content (TPC), polyphenol oxidase (PPO) activity, antioxidant activity (AOA), and the phenolic compound profile and the content of the allergenic protein Mal d 1 in six apple cultivars. It was found that the PPO activity and the content of individual phenolic compounds had an influence on the Mal d 1 content. With regard to the important constituents, flavan-3-ols and phenolic acids, it was found that apples with a higher content of chlorogenic acid and a low content of procyanidin trimers and/or epicatechin had a lower allergenic potential. This is probably based on the reaction of phenolic compounds (when oxidized by the endogenous PPO) with proteins, thus being able to change the conformation of the (allergenic) proteins, which further corresponds to a loss of antibody recognition. When apples were additionally biofortified with selenium, the composition of the apples, with regard to TPC, phenolic profile, AOA, and PPO, was significantly affected. Consequently, this innovative agronomic practice seems to be promising for reducing the allergenic potential of apples.

scholarly journals Genomic organisation of the Mal d 1 gene cluster on linkage group 16 in apple

2011 ◽  
Vol 29 (3) ◽  
pp. 759-778 ◽  
Author(s):  
Giulia Pagliarani ◽  
Roberta Paris ◽  
Anna Rosa Iorio ◽  
Stefano Tartarini ◽  
Stefano Del Duca ◽  
...  
Keyword(s):  
Linkage Group ◽  
Gene Cluster ◽  
Mal D 1 ◽  
Group 16 ◽  
Genomic Organisation

Development of an immunoassay for investigating the effects of post-harvest treatment on the levels of the major apple allergen, Mal d 1

2002 ◽  
Vol 30 (5) ◽  
pp. A129-A129
Author(s):  
E.N.C. Mills ◽  
N.M. Rigby ◽  
K. Waldron ◽  
T. Brown ◽  
K. Hoffmann-Sommergruber ◽  
...  
Keyword(s):  
Post Harvest ◽  
Mal D 1

scholarly journals Sublingual immunotherapy with recombinant Mal d 1 downregulates the allergen‐specific Th2 response

Allergy ◽  
2019 ◽  
Vol 74 (8) ◽  
pp. 1579-1581 ◽  
Author(s):  
Claudia Kitzmüller ◽  
Beatrice Jahn‐Schmid ◽  
Tamar Kinaciyan ◽  
Barbara Bohle
Keyword(s):  
Sublingual Immunotherapy ◽  
Th2 Response ◽  
Mal D 1

scholarly journals Tiered approach for the identification of Mal d 1 reduced, well tolerated apple genotypes

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Emilia Romer ◽  
Soraya Chebib ◽  
Karl-Christian Bergmann ◽  
Katrin Plate ◽  
Sylvia Becker ◽  
...  
Keyword(s):  
Tiered Approach ◽  
Mal D 1

scholarly journals Assessment of allelic diversity in intron-containing Mal d 1 genes and their association to apple allergenicity

2008 ◽  
Vol 8 (1) ◽  
pp. 116 ◽  
Author(s):  
Zhongshan Gao ◽  
Eric Weg ◽  
Catarina I Matos ◽  
Paul Arens ◽  
Suzanne THP Bolhaar ◽  
...  
Keyword(s):  
Allelic Diversity ◽  
Mal D 1

The optimal recombinant allergen for treatment of birch allergy should contain characteristics of both Bet v 1 and Mal d 1, the major apple allergen

2005 ◽  
Vol 115 (4) ◽  
pp. 894
Author(s):  
P.A. Würtzen ◽  
L. Lund ◽  
L. Hansen ◽  
A.H. Millner ◽  
M. Ferreras ◽  
...  
Keyword(s):  
Recombinant Allergen ◽  
Bet V 1 ◽  
Mal D 1

A mutant of the major apple allergen, Mal d 1, demonstrating hypo-allergenicity in the target organ by double-blind placebo-controlled food challenge

2005 ◽  
Vol 35 (12) ◽  
pp. 1638-1644 ◽  
Author(s):  
S. T. H. P. Bolhaar ◽  
L. Zuidmeer ◽  
Y. Ma ◽  
F. Ferreira ◽  
C. A. F. M. Bruijnzeel-Koomen ◽  
...  
Keyword(s):  
Food Challenge ◽  
Target Organ ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Mal D 1
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