Phenolic Elderberry Extracts, Anthocyanins, Procyanidins, and Metabolites Influence Glucose and Fatty Acid Uptake in Human Skeletal Muscle Cells

2017 ◽  
Vol 65 (13) ◽  
pp. 2677-2685 ◽  
Author(s):  
Giang Thanh Thi Ho ◽  
Eili Tranheim Kase ◽  
Helle Wangensteen ◽  
Hilde Barsett
2013 ◽  
Vol 2013 ◽  
pp. 1-2
Author(s):  
Nataša Nikolić ◽  
Magdalena Rhedin ◽  
Arild C. Rustan ◽  
Len Storlien ◽  
G. Hege Thoresen ◽  
...  

PLoS ONE ◽  
2018 ◽  
Vol 13 (11) ◽  
pp. e0208048 ◽  
Author(s):  
Nils G. Løvsletten ◽  
Siril S. Bakke ◽  
Eili T. Kase ◽  
D. Margriet Ouwens ◽  
G. Hege Thoresen ◽  
...  

2005 ◽  
Vol 35 (3) ◽  
pp. 465-476 ◽  
Author(s):  
X Fang ◽  
R Palanivel ◽  
X Zhou ◽  
Y Liu ◽  
A Xu ◽  
...  

Adiponectin has been shown to regulate glucose and fatty acid uptake and metabolism in skeletal muscle. Here we investigated the role of the recently cloned adiponectin receptor (AdipoR) isoforms in mediating effects of both globular (gAd) and full-length (fAd) adiponectin, and their regulation by hyperglycemia (25 mM, 20 h) and hyperinsulinemia (100 nM, 20 h). We used L6 rat skeletal muscle cells, which were found to express both AdipoR1 and AdipoR2 mRNA in a ratio of over 6:1 respectively. Hyperglycemia and hyperinsulinemia both decreased AdipoR1 receptor expression by approximately 50%, while the latter induced an increase of approximately threefold in AdipoR2 expression. The ability of gAd to increase GLUT4 myc translocation, glucose uptake, fatty acid uptake and oxidation, as well as AMP-activated protein kinase (AMPK) and acetyl-CoA carboxylase (ACC) phosphorylation, was decreased by both hyperglycemia and hyperinsulinemia. Interestingly, hyperinsulinemia induced the ability of fAd to elicit fatty acid uptake and enhanced fatty acid oxidation in response to fAd. In summary, our results suggest that both hyperglycemia and hyperinsulinemia cause gAd resistance in rat skeletal muscle cells. However, hyperinsulinemia induces a switch toward increased fAd sensitivity in these cells.


2005 ◽  
Vol 47 (2) ◽  
pp. 366-374 ◽  
Author(s):  
Vigdis Aas ◽  
Merethe H. Rokling-Andersen ◽  
Eili Tranheim Kase ◽  
G. Hege Thoresen ◽  
Arild C. Rustan

2018 ◽  
Author(s):  
S Höckele ◽  
P Huypens ◽  
C Hoffmann ◽  
T Jeske ◽  
M Hastreiter ◽  
...  

2003 ◽  
Vol 14 (15) ◽  
pp. 1473-1487 ◽  
Author(s):  
Martha Wootton ◽  
Karen Steeghs ◽  
Diana Watt ◽  
June Munro ◽  
Katrina Gordon ◽  
...  

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