Lauric Acid Stimulates Mammary Gland Development of Pubertal Mice through Activation of GPR84 and PI3K/Akt Signaling Pathway

2016 ◽  
Vol 65 (1) ◽  
pp. 95-103 ◽  
Author(s):  
Yingying Meng ◽  
Jing Zhang ◽  
Fenglin Zhang ◽  
Wei Ai ◽  
Xiaotong Zhu ◽  
...  
Keyword(s):  
Mammary Gland ◽  
Signaling Pathway ◽  
Lauric Acid ◽  
Mammary Gland Development ◽  
Akt Signaling ◽  
Akt Signaling Pathway ◽  
Gland Development

scholarly journals CUZD1 is a critical mediator of the JAK/STAT5 signaling pathway that controls mammary gland development during pregnancy

PLoS Genetics ◽  
2017 ◽  
Vol 13 (3) ◽  
pp. e1006654 ◽  
Author(s):  
Janelle Mapes ◽  
Quanxi Li ◽  
Athilakshmi Kannan ◽  
Lavanya Anandan ◽  
Mary Laws ◽  
...  
Keyword(s):  
Mammary Gland ◽  
Signaling Pathway ◽  
Mammary Gland Development ◽  
Gland Development

Wnt Signaling Pathway in Mammary Gland Development and Carcinogenesis

Pathobiology ◽  
2006 ◽  
Vol 73 (5) ◽  
pp. 213-223 ◽  
Author(s):  
Gulisa Turashvili ◽  
Jan Bouchal ◽  
George Burkadze ◽  
Zdenek Kolar
Keyword(s):  
Mammary Gland ◽  
Wnt Signaling ◽  
Signaling Pathway ◽  
Mammary Gland Development ◽  
Wnt Signaling Pathway ◽  
Gland Development

scholarly journals Effects of Dietary Supplementation of Lauric Acid on Lactation Function, Mammary Gland Development, and Serum Lipid Metabolites in Lactating Mice

Animals ◽  
2020 ◽  
Vol 10 (3) ◽  
pp. 529 ◽  
Author(s):  
Lin Yang ◽  
Qiang Yang ◽  
Fan Li ◽  
Wuzhou Yi ◽  
Fangfang Liu ◽  
...  
Keyword(s):  
Body Weight ◽  
Mammary Gland ◽  
Lauric Acid ◽  
Serum Lipid ◽  
Mammary Gland Development ◽  
Dietary Supplementation ◽  
Mammary Glands ◽  
Lipid Metabolites ◽  
Gland Development

Our previous studies demonstrated that lauric acid (LA) stimulated mammary gland development during puberty. However, the roles of LA on lactation in mice remain indeterminate. Thus, the aim of this study was to investigate the effects of dietary LA supplementation on lactation functioning and to study the potential mechanisms during lactation. in vivo, there was no effect of 1% LA dietary supplementation during lactation on the feed intake or body weight of breast-feeding mice. However, maternal LA supplementation significantly expanded the number of mammary gland alveoli of mice during lactation and the average body weight of the offspring, suggesting that LA supplementation enhanced the development and lactation function of the mammary glands. in vitro, 100 μM of LA significantly increased the content of triglycerides (TG) in the cell supernatant of induced HC11 cells, however, with no effect on the expression of the genes associated with fatty acid synthesis. LA also activated the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) signaling pathway. LA dietary supplementation significantly expanded the serum levels of lipid metabolites, including sphingomyelin and other metabolites with the sn-2 position of C12 and sn-1 position of C18 in the TG of the lactating mice. Taken together, dietary supplementation of LA during lactation could promote the lactation function of mice, which might be related to increasing the development of the mammary glands and alternation of serum lipid metabolites. These findings provided more theoretical and experimental basis for the application of lauric acid in the development of mammary glands and lactation function of lactating animals.

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