Adenine Inhibits TNF-α Signaling in Intestinal Epithelial Cells and Reduces Mucosal Inflammation in a Dextran Sodium Sulfate-Induced Colitis Mouse Model

2016 ◽  
Vol 64 (21) ◽  
pp. 4227-4234 ◽  
Author(s):  
Toshihiko Fukuda ◽  
Kaustav Majumder ◽  
Hua Zhang ◽  
Patricia V. Turner ◽  
Toshiro Matsui ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Mouse Model ◽  
Sodium Sulfate ◽  
Intestinal Epithelial Cells ◽  
Dextran Sodium Sulfate ◽  
Mucosal Inflammation ◽  
Intestinal Epithelial ◽  
Tnf Α

scholarly journals Cholera Toxin B Subunit and Peptide LKEKK Inhibit TNF-α Signaling in Intestinal Epithelial Cells and Reduce Inflammation in a Mouse Model of Colitis

2019 ◽  
Vol 4 (4) ◽  
Keyword(s):  
Epithelial Cells ◽  
Mouse Model ◽  
Inflammatory Cytokine ◽  
Intestinal Epithelial Cells ◽  
Cholera Toxin B Subunit ◽  
Intestinal Epithelial ◽  
Toxin B ◽  
Cholera Toxin B ◽  
B Subunit ◽  
Tnf Α

Cholera toxin B subunit (CT-B) and synthetic peptide LKEKK corresponding to the sequence 16-20 of thymosin-α1 and the sequence 131-135 of interferon-α2 (the concentration range of 100-5000 µM) significantly reduced TNF-α-stimulated pro-inflammatory cytokine expression and increases the expression of the anti-inflammatory cytokine IL-10 in human Caco-2 intestinal epithelial cells. In a mouse model of dextran sodium sulfate-induced colitis CT-B and peptide, LKEKK (20 mg/kg body weight orally for 14 days) decreased the production of TNF-α and IL-6, as well as the severity of inflammation. Thus, CT-B and peptide LKEKK are able to suppress inflammation in vitro and in vivo.

scholarly journals Intestinal Epithelial Cells With Impaired Autophagy Lose Their Adhesive Capacity in the Presence of TNF-α

2011 ◽  
Vol 140 (5) ◽  
pp. S-84
Author(s):  
Masaya Saito ◽  
Tomoo Nakagawa ◽  
Yoshiko Noguchi ◽  
Toru Sato ◽  
Tatsuro Katsuno ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Intestinal Epithelial Cells ◽  
Intestinal Epithelial ◽  
Tnf Α ◽  
Adhesive Capacity
Sign in / Sign up

Export Citation Format

Share Document