2α-Hydroxyursolic Acid Inhibited Cell Proliferation and Induced Apoptosis in MDA-MB-231 Human Breast Cancer Cells through the p38/MAPK Signal Transduction Pathway

2016 ◽  
Vol 64 (8) ◽  
pp. 1806-1816 ◽  
Author(s):  
Xue Jiang ◽  
Tong Li ◽  
Rui Hai Liu
Keyword(s):  
Breast Cancer ◽  
Signal Transduction ◽  
Cell Proliferation ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Signal Transduction Pathway ◽  
Transduction Pathway ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Induced Apoptosis

Involvement of JNK/p73/NOXA in vitamin E analog-induced apoptosis of human breast cancer cells

2008 ◽  
Vol 47 (6) ◽  
pp. 436-445 ◽  
Author(s):  
Pei Wang ◽  
Weiping Yu ◽  
Zhanzhi Hu ◽  
Li Jia ◽  
Vishwanath R. Iyer ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Vitamin E ◽  
Cancer Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Induced Apoptosis

scholarly journals Mango Fruit Extracts Differentially Affect Proliferation and Intracellular Calcium Signalling in MCF-7 Human Breast Cancer Cells

2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
Meng-Wong Taing ◽  
Jean-Thomas Pierson ◽  
Paul N. Shaw ◽  
Ralf G. Dietzgen ◽  
Sarah J. Roberts-Thomson ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Proliferation ◽  
Intracellular Calcium ◽  
Cancer Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Cultivar Differences ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Mcf 7

The assessment of human cancer cell proliferation is a common approach in identifying plant extracts that have potential bioactive effects. In this study, we tested the hypothesis that methanolic extracts of peel and flesh from three archetypal mango cultivars, Irwin (IW), Nam Doc Mai (NDM), and Kensington Pride (KP), differentially affect proliferation, extracellular signal-regulated kinase (ERK) activity, and intracellular calcium ([Ca2+]I) signalling in MCF-7 human breast cancer cells. Mango flesh extracts from all three cultivars did not inhibit cell growth, and of the peel extracts only NDM reduced MCF-7 cell proliferation. Mango cultivar peel and flesh extracts did not significantly change ERK phosphorylation compared to controls; however, some reduced relative maximal peak[Ca2+]Iafter adenosine triphosphate stimulation, with NDM peel extract having the greatest effect among the treatments. Our results identify mango interfruit and intrafruit (peel and flesh) extract variability in antiproliferative effects and[Ca2+]Isignalling in MCF-7 breast cancer cells and highlight that parts of the fruit (such as peel and flesh) and cultivar differences are important factors to consider when assessing potential chemopreventive bioactive compounds in plants extracts.

Survivin plays as a resistant factor against tamoxifen-induced apoptosis in human breast cancer cells

2008 ◽  
Vol 117 (2) ◽  
pp. 261-271 ◽  
Author(s):  
Ryosuke Moriai ◽  
Naoki Tsuji ◽  
Mikako Moriai ◽  
Daisuke Kobayashi ◽  
Naoki Watanabe
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Induced Apoptosis

Enhancement of paclitaxel-induced apoptosis in HER2-overexpressing human breast cancer cells by a pertuzumab mimetic peptide, HRAP

2010 ◽  
Vol 110 (2) ◽  
pp. 250-253 ◽  
Author(s):  
Hiroo Nakajima ◽  
Naruhiko Mizuta ◽  
Koichi Sakaguchi ◽  
Ikuya Fujiwara ◽  
Atsushi Yoshimori ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Mimetic Peptide ◽  
Induced Apoptosis

Involvement of Akt/NF-κB pathway in N6-isopentenyladenosine-induced apoptosis in human breast cancer cells

2010 ◽  
Vol 49 (10) ◽  
pp. 892-901 ◽  
Author(s):  
Chiara Laezza ◽  
Anna M. Malfitano ◽  
Tiziana Di Matola ◽  
Paolo Ricchi ◽  
Maurizio Bifulco
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Induced Apoptosis

Calcitriol inhibits Ether-à go-go potassium channel expression and cell proliferation in human breast cancer cells

2010 ◽  
Vol 316 (3) ◽  
pp. 433-442 ◽  
Author(s):  
Rocío García-Becerra ◽  
Lorenza Díaz ◽  
Javier Camacho ◽  
David Barrera ◽  
David Ordaz-Rosado ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Proliferation ◽  
Potassium Channel ◽  
Cancer Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Channel Expression
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