Human Ether-à-go-go Related Gene (hERG) Channel Blocking Aporphine Alkaloids from Lotus Leaves and Their Quantitative Analysis in Dietary Weight Loss Supplements

2015 ◽  
Vol 63 (23) ◽  
pp. 5634-5639 ◽  
Author(s):  
Ulrike Grienke ◽  
Christina E. Mair ◽  
Priyanka Saxena ◽  
Igor Baburin ◽  
Olaf Scheel ◽  
...  
Keyword(s):  
Weight Loss ◽  
Quantitative Analysis ◽  
Herg Channel ◽  
Related Gene ◽  
Channel Blocking ◽  
Lotus Leaves ◽  
Dietary Weight Loss

How to Fluorescently Label the Potassium Channel: A Case in hERG

2020 ◽  
Vol 27 (18) ◽  
pp. 3046-3054
Author(s):  
Xiaomeng Zhang ◽  
Beilei Wang ◽  
Zhenzhen Liu ◽  
Yubin Zhou ◽  
Lupei Du
Keyword(s):  
Potassium Channel ◽  
Herg Channel ◽  
Pore Channel ◽  
Design Rationale ◽  
Related Gene ◽  
Open Conformation ◽  
Cardiac Action ◽  
Qt Syndrome ◽  
Herg Channels ◽  
Action Potential Repolarization

hERG (Human ether-a-go-go-related gene) potassium channel, which plays an essential role in cardiac action potential repolarization, is responsible for inherited and druginduced long QT syndrome. Recently, the Cryo-EM structure capturing the open conformation of hERG channel was determined, thus pushing the study on hERG channel at 3.8 Å resolution. This report focuses primarily on summarizing the design rationale and application of several fluorescent probes that target hERG channels, which enables dynamic and real-time monitoring of potassium pore channel affinity to further advance the understanding of the channels.

scholarly journals Eating behaviors and weight loss outcomes in a 12-month randomized trial of diet and/or exercise intervention in postmenopausal women

2019 ◽  
Vol 16 (1) ◽  
Author(s):  
Caitlin Mason ◽  
Jean de Dieu Tapsoba ◽  
Catherine Duggan ◽  
Ching-Yun Wang ◽  
Catherine M. Alfano ◽  
...  
Keyword(s):  
Weight Loss ◽  
Binge Eating ◽  
Postmenopausal Women ◽  
Eating Behavior ◽  
Emotional Eating ◽  
Eating Behaviors ◽  
Dietary Intervention ◽  
Restrained Eating ◽  
Dietary Weight Loss ◽  
Uncontrolled Eating

Abstract Background Certain eating behaviors are common among women with obesity. Whether these behaviors influence outcomes in weight loss programs, and whether such programs affect eating behaviors, is unclear. Methods Our aim was to examine the effect of baseline eating behaviors on intervention adherence and weight among postmenopausal women with overweight or obesity, and to assess intervention effects on eating behaviors. Four hundred and 39 women (BMI ≥25 kg/m2) were randomized to 12 months of: i) dietary weight loss with a 10% weight loss goal (‘diet’; n = 118); ii) moderate-to-vigorous intensity aerobic exercise for 225 mins/week (‘exercise’; n = 117); iii) combined dietary weight loss and exercise (‘diet + exercise’; n = 117); or iv) no-lifestyle change control (n = 87). At baseline and 12 months, restrained eating, uncontrolled eating, emotional eating and binge eating were measured by questionnaire; weight and body composition were assessed. The mean change in eating behavior scores and weight between baseline and 12 months in the diet, exercise, and diet + exercise arms were each compared to controls using the generalized estimating equation (GEE) modification of linear regression adjusted for age, baseline BMI, and race/ethnicity. Results Baseline restrained eating was positively associated with change in total calories and calories from fat during the dietary intervention but not with other measures of adherence. Higher baseline restrained eating was associated with greater 12-month reductions in weight, waist circumference, body fat and lean mass. Women randomized to dietary intervention had significant reductions in binge eating (− 23.7%, p = 0.005 vs. control), uncontrolled eating (− 24.3%, p < 0.001 vs. control), and emotional eating (− 31.7%, p < 0.001 vs. control) scores, and a significant increase in restrained eating (+ 60.6%, p < 0.001 vs. control); women randomized to diet + exercise reported less uncontrolled eating (− 26.0%, p < 0.001 vs. control) and emotional eating (− 22.0%, p = 0.004 vs. control), and increased restrained eating (+ 41.4%, p < 0.001 vs. control). Women randomized to exercise alone had no significant change in eating behavior scores compared to controls. Conclusions A dietary weight loss intervention helped women modify eating behaviors. Future research should investigate optimal behavioral weight loss interventions for women with both disordered eating and obesity. Trial registration NCT00470119 (https://clinicaltrials.gov). Retrospectively registered May 7, 2007.

Effects of dietary weight loss with and without exercise on fibrosis biomarkers in adults with knee osteoarthritis

2021 ◽  
Vol 29 ◽  
pp. S157-S158
Author(s):  
A.-C. Bay-Jensen ◽  
R. Loeser ◽  
P. Frederiksen ◽  
D. Beaver ◽  
M.A. Karsdal ◽  
...  
Keyword(s):  
Weight Loss ◽  
Knee Osteoarthritis ◽  
Dietary Weight Loss

scholarly journals A feasibility study to test a novel approach to dietary weight loss with a focus on assisting informed decision making in food selection

2021 ◽  
Author(s):  
Mindy Lee ◽  
Catherine C Applegate ◽  
Annabelle L Shaffer ◽  
Abrar Emamaddin ◽  
John W Erdman ◽  
...  
Keyword(s):  
Decision Making ◽  
Weight Loss ◽  
Food Selection ◽  
Informed Decision ◽  
Informed Decision Making ◽  
Fiber Density ◽  
Improvement Program ◽  
Novel Approach ◽  
Dietary Weight Loss ◽  
Protein Density

Obesity is a significant contributor to the development of chronic diseases, some of which can be prevented or reversed by weight loss. However, dietary weight loss programs have shortcomings in success rate and magnitude or sustainability of weight loss. The objective of the Individualized Diet Improvement Program (iDip) was to test the feasibility of a novel approach that helps individuals self-select a sustainable diet for weight loss and maintenance instead of providing weight loss products or rigid diet instructions to follow. The iDip study consisted of 22 dietary improvement sessions over 12 months with six months of follow-up. Daily weights were collected, and a chart summarizing progress was provided weekly. Six 24-hour dietary records were collected, and dietary feedback was provided in the form of a protein-fiber plot, in which protein/energy and fiber/energy of foods were plotted two-dimensionally together with a target box specific to weight loss or maintenance. An exit survey was conducted at 12 months. Twelve (nine female, 46.3±3.1 years (mean±SE)) of the initial 14 participants (BMI>28 kg/m2) completed all sessions. Mean percent weight loss (n=12) at six and 12 months was -4.9%±1.1 (p=0.001) and -5.4%±1.7 (p=0.007), respectively. Weight loss varied among individuals at 12 months; top and bottom halves (n=6 each) achieved -9.7%±1.7 (p=0.0008) and -1.0%±1.4 weight loss, respectively. The 24-hour records showed a significant increase in protein density from baseline to final (4.1g/100kcal±0.3 vs. 5.7g/100kcal±0.5 (p=0.008)). Although mean fiber density showed no significant change from the first month (1.3g/100kcal±0.1), the top half had significantly higher fiber/energy intake than the bottom half group. The survey suggested that all participants valued the program and its individualized approach. In conclusion, half of the participants successfully lost >5% and maintained the lost weight for 12 months without strict diet instructions, showing the feasibility of the informed decision-making approach.

scholarly journals Long-Lasting Improvements in Liver Fat and Metabolism Despite Body Weight Regain After Dietary Weight Loss

Diabetes Care ◽  
2013 ◽  
Vol 36 (11) ◽  
pp. 3786-3792 ◽  
Author(s):  
S. Haufe ◽  
V. Haas ◽  
W. Utz ◽  
A. L. Birkenfeld ◽  
S. Jeran ◽  
...  
Keyword(s):  
Weight Loss ◽  
Body Weight ◽  
Weight Regain ◽  
Liver Fat ◽  
Dietary Weight Loss

Dietary weight loss in people with severe obesity stabilizes neuropathy and improves symptomatology

Obesity ◽  
2021 ◽  
Author(s):  
Brian C. Callaghan ◽  
Evan L. Reynolds ◽  
Mousumi Banerjee ◽  
Gulcin Akinci ◽  
Ericka Chant ◽  
...  
Keyword(s):  
Weight Loss ◽  
Severe Obesity ◽  
Dietary Weight Loss
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