Influence of a Biotechnologically Produced Oyster Mushroom (Pleurotus sajor-caju) on the Gut Microbiota and Microbial Metabolites in Obese Zucker Rats

2021 ◽  
Vol 69 (5) ◽  
pp. 1524-1535
Author(s):  
Garima Maheshwari ◽  
Denise K. Gessner ◽  
Klaus Neuhaus ◽  
Erika Most ◽  
Holger Zorn ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Oyster Mushroom ◽  
Zucker Rats ◽  
Microbial Metabolites ◽  
Obese Zucker Rats ◽  
Pleurotus Sajor Caju

Feeding of cuticles from Tenebrio molitor larvae modulates the gut microbiota and attenuates hepatic steatosis in obese Zucker rats

2022 ◽  
Author(s):  
Armaghan Saeb ◽  
Sarah Maria Grundmann ◽  
Denise K Gessner ◽  
Sven Schuchardt ◽  
Erika Most ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Hepatic Steatosis ◽  
Mass Rearing ◽  
Tenebrio Molitor ◽  
Zucker Rats ◽  
Insect Larvae ◽  
Food And Feed ◽  
Obese Zucker Rats ◽  
Tenebrio Molitor Larvae

an alternative and sustainable source of food and feed. A byproduct from mass-rearing of insect larvae are the shed cuticles - the most external components of insects which are a...

Tandem mass tag-based proteomics for studying the effects of a biotechnologically produced oyster mushroom against hepatic steatosis in obese Zucker rats

2021 ◽  
pp. 104255
Author(s):  
Garima Maheshwari ◽  
Gaiping Wen ◽  
Denise K. Gessner ◽  
Robert Ringseis ◽  
Günter Lochnit ◽  
...  
Keyword(s):  
Hepatic Steatosis ◽  
Oyster Mushroom ◽  
Zucker Rats ◽  
Tandem Mass ◽  
Tandem Mass Tag ◽  
Obese Zucker Rats ◽  
Mass Tag

scholarly journals High intensity interval training promotes total and visceral fat mass loss in obese Zucker rats without modulating gut microbiota

PLoS ONE ◽  
2019 ◽  
Vol 14 (4) ◽  
pp. e0214660 ◽  
Author(s):  
Florie Maillard ◽  
Emilie Vazeille ◽  
Pierre Sauvanet ◽  
Pascal Sirvent ◽  
Lydie Combaret ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Mass Loss ◽  
Visceral Fat ◽  
High Intensity ◽  
Interval Training ◽  
Zucker Rats ◽  
High Intensity Interval Training ◽  
Obese Zucker Rats ◽  
High Intensity Interval ◽  
Fat Mass Loss

scholarly journals Assessment of gut microbiota populations in lean and obese Zucker rats

PLoS ONE ◽  
2017 ◽  
Vol 12 (7) ◽  
pp. e0181451 ◽  
Author(s):  
Reza Hakkak ◽  
Soheila Korourian ◽  
Steven L. Foley ◽  
Bruce D. Erickson
Keyword(s):  
Gut Microbiota ◽  
Zucker Rats ◽  
Obese Zucker Rats

scholarly journals Characterization of the Nutritional Composition of a Biotechnologically Produced Oyster Mushroom and its Physiological Effects in Obese Zucker Rats

2020 ◽  
Vol 64 (22) ◽  
pp. 2000591
Author(s):  
Garima Maheshwari ◽  
Denise K. Gessner ◽  
Sandra Meyer ◽  
Jenny Ahlborn ◽  
Gaiping Wen ◽  
...  
Keyword(s):  
Nutritional Composition ◽  
Oyster Mushroom ◽  
Zucker Rats ◽  
Physiological Effects ◽  
Obese Zucker Rats

Targeting the Endothelial Ca2+ Toolkit to Rescue Endothelial Dysfunction in Obesity Associated-Hypertension

2020 ◽  
Vol 27 (2) ◽  
pp. 240-257 ◽  
Author(s):  
Francesco Moccia ◽  
Sharon Negri ◽  
Pawan Faris ◽  
Roberto Berra-Romani
Keyword(s):  
Transient Receptor Potential ◽  
Receptor Potential ◽  
Endothelial Damage ◽  
Vascular Damage ◽  
Zucker Rats ◽  
Bibliographic Databases ◽  
Resistance Arteries ◽  
Small Resistance ◽  
Obese Zucker Rats ◽  
Transient Receptor

Background: Obesity is a major cardiovascular risk factor which dramatically impairs endothelium- dependent vasodilation and leads to hypertension and vascular damage. The impairment of the vasomotor response to extracellular autacoids, e.g., acetylcholine, mainly depends on the reduced Nitric Oxide (NO) bioavailability, which hampers vasorelaxation in large conduit arteries. In addition, obesity may affect Endothelium-Dependent Hyperpolarization (EDH), which drives vasorelaxation in small resistance arteries and arterioles. Of note, endothelial Ca2+ signals drive NO release and trigger EDH. Methods: A structured search of bibliographic databases was carried out to retrieve the most influential, recent articles on the impairment of vasorelaxation in animal models of obesity, including obese Zucker rats, and on the remodeling of the endothelial Ca2+ toolkit under conditions that mimic obesity. Furthermore, we searched for articles discussing how dietary manipulation could be exploited to rescue Ca2+-dependent vasodilation. Results: We found evidence that the endothelial Ca2+ could be severely affected by obese vessels. This rearrangement could contribute to endothelial damage and is likely to be involved in the disruption of vasorelaxant mechanisms. However, several Ca2+-permeable channels, including Vanilloid Transient Receptor Potential (TRPV) 1, 3 and 4 could be stimulated by several food components to stimulate vasorelaxation in obese individuals. Conclusion: The endothelial Ca2+ toolkit could be targeted to reduce vascular damage and rescue endothelium- dependent vasodilation in obese vessels. This hypothesis remains, however, to be probed on truly obese endothelial cells.

scholarly journals Microbial Metabolites in Colorectal Cancer: Basic and Clinical Implications

Metabolites ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 159
Author(s):  
Yao Peng ◽  
Yuqiang Nie ◽  
Jun Yu ◽  
Chi Chun Wong
Keyword(s):  
Colorectal Cancer ◽  
Gut Microbiota ◽  
Cancer Diagnosis ◽  
Intestinal Tract ◽  
Clinical Applications ◽  
Diagnosis And Treatment ◽  
Clinical Implications ◽  
Microbial Metabolites ◽  
Colorectal Tumorigenesis ◽  
Technology Studies

Colorectal cancer (CRC) is one of the leading cancers that cause cancer-related deaths worldwide. The gut microbiota has been proved to show relevance with colorectal tumorigenesis through microbial metabolites. By decomposing various dietary residues in the intestinal tract, gut microbiota harvest energy and produce a variety of metabolites to affect the host physiology. However, some of these metabolites are oncogenic factors for CRC. With the advent of metabolomics technology, studies profiling microbiota-derived metabolites have greatly accelerated the progress in our understanding of the host-microbiota metabolism interactions in CRC. In this review, we briefly summarize the present metabolomics techniques in microbial metabolites researches and the mechanisms of microbial metabolites in CRC pathogenesis, furthermore, we discuss the potential clinical applications of microbial metabolites in cancer diagnosis and treatment.

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