Herbicidal Characteristics and Structural Identification of the Potential Active Compounds from Streptomyces sp. KRA17-580

2020 ◽  
Vol 68 (52) ◽  
pp. 15373-15380
Author(s):  
Hye Jin Kim ◽  
Aung B. Bo ◽  
Jae Deok Kim ◽  
Young Sook Kim ◽  
Botir Khaitov ◽  
...  
Keyword(s):  
Structural Identification ◽  
Active Compounds ◽  
Streptomyces Sp

scholarly journals Correction to Herbicidal Characteristics and Structural Identification of the Potential Active Compounds from Streptomyces sp. KRA17-580

2021 ◽  
Vol 69 (7) ◽  
pp. 2364-2364
Author(s):  
Hye Jin Kim ◽  
Aung Bo Bo ◽  
Jae Deok Kim ◽  
Young Sook Kim ◽  
Botir Khaitov ◽  
...  
Keyword(s):  
Structural Identification ◽  
Active Compounds ◽  
Streptomyces Sp

scholarly journals Pengaruh Perbedaan Metode Ekstraksi Metabolit Sekunder Streptomyces sp. GMR22 terhadap Toksisitas pada Sel BHK-21

2019 ◽  
Vol 16 (1) ◽  
pp. 1-10
Author(s):  
Diani Mentari ◽  
Mirtani Naima ◽  
Riska Wulansari ◽  
Jaka Widada ◽  
Tri Rini Nuringtyas ◽  
...  
Keyword(s):  
Secondary Metabolites ◽  
Ethyl Acetate ◽  
Polar Solvent ◽  
Ethyl Acetate Extract ◽  
Water Extract ◽  
Host Cells ◽  
Extraction Technique ◽  
Active Compounds ◽  
Streptomyces Sp ◽  
Separatory Funnel

Streptomyces sp. GMR22 is local isolate from Wanagama 1 Forest in Yogyakarta. They have the potential to be developed to produce active compounds because have PKS and NRPS genes.The active compounds from isolation are strongly influenced by various factors, one of them is extraction techniques. Effect difference of extraction technique will be affected by the quality of secondary metabolites produced.The purpose of this study was to compare the cytotoxicity effects of secondary metabolites of Streptomyces sp. GMR22 which have extracted with different stages from previous studies. The extraction technique was carried out by multilevel separatory funnel extraction methods, which was first extracted using non-polar solvent (n-hexane) and then extracted using semi-polar solvent (ethyl acetate). This research is important because in previous studies (separatory funnel only extracted using ethyl acetate) with the use of the lowest concentration in the dengue virus antiviral test (further test) caused 100% of deaths in BHK-21 cells.This study indicate that multilevel extraction result in lower CC50 value than previous studies. There are 49.160 µl/ml (n-hexane extract) and 284.56 µl/ml (ethyl acetate extract) while water extract is 464,38 µl/ml. FTIR compound analysis show that the three extracts produced have different spectrum patterns, especially in the n-hexane and ethyl acetate extract. Value of CC50 is not too high, it is expected that the secondary metabolites contained in the extracts can be used for further analysis such as antiviral testing because it is safe for normal host cells such as BHK-21 cells

scholarly journals Antiplasmodial activity and genome mining study of marine-derived Streptomyces sp. GMY01

2021 ◽  
Vol 2 (2) ◽  
Author(s):  
Ema Damayanti ◽  
Jaka Widada ◽  
Achmad Dinoto ◽  
Mustofa
Keyword(s):  
Polyketide Synthase ◽  
Genome Mining ◽  
Gene Clusters ◽  
Antiplasmodial Activity ◽  
Active Compounds ◽  
Streptomyces Sp ◽  
Ic50 Value ◽  
Peptide Synthetase ◽  
Genes Encoding

High resistance to chloroquine in most malaria-endemic area in the world leads to the need for new antimalaria drugs. Marine bacterium Streptomyces  is the source for potential new antimalarial molecules. This research aimed to investigate antiplasmodial activity of marine-derived of Streptomyces sp. GMY01 and to identify potential active compounds using genome mining study. In vitro antiplasmodial activity assays using flow cytometry method showed that the ethyl acetate extract of this bacterium had high antiplasmodial activity (IC50 value of 1.183 µg/mL) on Plasmodium falciparum FCR3. Genome mining analysis of whole-genome sequences using antiSMASH 6.0 beta version revealed that Streptomyces sp. GMY01 had 28 biosynthetic gene clusters (BGCs), including the genes encoding polyketide synthase, non-ribosomal peptide synthetase, terpene, lanthipeptide, bacteriocin, butyrolactone, ectoin, siderophore, and others. The known BGCs were predicted to be involved in the production of known compounds from gene clusters ranged from 5 to 100% similarity. Ongoing purification and elucidation of the structures will allow identification of the active compounds produced by marine-derived Streptomyces sp. GMY01.

Bioguided fractionation of the antimalarial plant Argemone mexicana: isolation and quantification of active compounds from effective clinical batches

Planta Medica ◽  
2009 ◽  
Vol 75 (09) ◽  
Author(s):  
CA Simões-Pires ◽  
EA Diop ◽  
JR Ioset ◽  
J Falquet ◽  
A Matheeussen ◽  
...  
Keyword(s):  
Argemone Mexicana ◽  
Active Compounds

Screening of some Asteraceae to discover new active compounds against Trypanosoma brucei by metabolite profiling and PLS analysis

Planta Medica ◽  
2013 ◽  
Vol 79 (13) ◽  
Author(s):  
MS Nogueira ◽  
FB da Costa ◽  
MA Magenta ◽  
M Kaiser ◽  
R Brun ◽  
...  
Keyword(s):  
Trypanosoma Brucei ◽  
Metabolite Profiling ◽  
Active Compounds ◽  
Pls Analysis

Structure determination and biosynthesis of the antifungal butyrolactols from Streptomyces sp.

Planta Medica ◽  
2016 ◽  
Vol 81 (S 01) ◽  
pp. S1-S381 ◽  
Author(s):  
K Ko ◽  
HM Ge ◽  
J Shin ◽  
DC Oh
Keyword(s):  
Structure Determination ◽  
Streptomyces Sp
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