scholarly journals Metabolite Quantitative Trait Loci for Flavonoids Provide New Insights into the Genetic Architecture of Strawberry (Fragaria × ananassa) Fruit Quality

2020 ◽  
Vol 68 (25) ◽  
pp. 6927-6939
Author(s):  
Marc Labadie ◽  
Guillaume Vallin ◽  
Aurélie Petit ◽  
Ludwig Ring ◽  
Thomas Hoffmann ◽  
...  
2011 ◽  
Vol 123 (5) ◽  
pp. 755-778 ◽  
Author(s):  
Yasmín Zorrilla-Fontanesi ◽  
Amalia Cabeza ◽  
Pedro Domínguez ◽  
Juan Jesús Medina ◽  
Victoriano Valpuesta ◽  
...  

Genome ◽  
2007 ◽  
Vol 50 (8) ◽  
pp. 714-723 ◽  
Author(s):  
L. Gyenis ◽  
S.J. Yun ◽  
K.P. Smith ◽  
B.J. Steffenson ◽  
E. Bossolini ◽  
...  

Hordeum vulgare subsp. spontaneum is the progenitor of cultivated barley (Hordeum vulgare L.). Domestication combined with plant breeding has led to the morphological and agronomic characteristics of modern barley cultivars. The objective of this study was to map the genetic factors that morphologically and agronomically differentiate wild barley from modern barley cultivars. To address this objective, we identified quantitative trait loci (QTLs) associated with plant height, flag leaf width, spike length, spike width, glume length in relation to seed length, awn length, fragility of ear rachis, endosperm width and groove depth, heading date, flag leaf length, number of tillers per plant, and kernel color in a Harrington/OUH602 advanced backcross (BC2F8) population. This population was genotyped with 113 simple sequence repeat markers. Thirty QTLs were identified, of which 16 were newly identified in this study. One to 4 QTLs were identified for each of the traits except glume length, for which no QTL was detected. The portion of phenotypic variation accounted for by individual QTLs ranged from about 9% to 54%. For traits with more than one QTL, the phenotypic variation explained ranged from 25% to 71%. Taken together, our results reveal the genetic architecture of morphological and agronomic traits that differentiate wild from cultivated barley.


2013 ◽  
Vol 32 (1) ◽  
pp. 109-116 ◽  
Author(s):  
Sarah M. Potts ◽  
M. Awais Khan ◽  
Yuepeng Han ◽  
Mosbah M. Kushad ◽  
Schuyler S. Korban

BMC Genomics ◽  
2013 ◽  
Vol 14 (1) ◽  
pp. 360 ◽  
Author(s):  
Erin L McAdam ◽  
Jules S Freeman ◽  
Simon P Whittock ◽  
Emily J Buck ◽  
Jernej Jakse ◽  
...  

2019 ◽  
Vol 6 (1) ◽  
Author(s):  
Charlotte F. Nellist ◽  
Robert J. Vickerstaff ◽  
Maria K. Sobczyk ◽  
César Marina-Montes ◽  
Fiona M. Wilson ◽  
...  

Genetics ◽  
2020 ◽  
Vol 216 (1) ◽  
pp. 241-259
Author(s):  
Excel Que ◽  
Kristen L. James ◽  
Alisha R. Coffey ◽  
Tangi L. Smallwood ◽  
Jody Albright ◽  
...  

Genetic approaches in model organisms have consistently demonstrated that molecular traits such as gene expression are under genetic regulation, similar to clinical traits. The resulting expression quantitative trait loci (eQTL) have revolutionized our understanding of genetic regulation and identified numerous candidate genes for clinically relevant traits. More recently, these analyses have been extended to other molecular traits such as protein abundance, metabolite levels, and miRNA expression. Here, we performed global hepatic eQTL and microRNA expression quantitative trait loci (mirQTL) analysis in a population of Diversity Outbred mice fed two different diets. We identified several key features of eQTL and mirQTL, namely differences in the mode of genetic regulation (cis or trans) between mRNA and miRNA. Approximately 50% of mirQTL are regulated by a trans-acting factor, compared to ∼25% of eQTL. We note differences in the heritability of mRNA and miRNA expression and variance explained by each eQTL or mirQTL. In general, cis-acting variants affecting mRNA or miRNA expression explain more phenotypic variance than trans-acting variants. Lastly, we investigated the effect of diet on the genetic architecture of eQTL and mirQTL, highlighting the critical effects of environment on both eQTL and mirQTL. Overall, these data underscore the complex genetic regulation of two well-characterized RNA classes (mRNA and miRNA) that have critical roles in the regulation of clinical traits and disease susceptibility.


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