A Global, Cross-System Meta-Analysis of Polychlorinated Biphenyl Biomagnification

2020 ◽  
Vol 54 (18) ◽  
pp. 10989-11001
Author(s):  
Kimberly D. Prince ◽  
Shawn D. Taylor ◽  
Christine Angelini
Keyword(s):  
Polychlorinated Biphenyl ◽  
Meta Analysis ◽  
Cross System

scholarly journals A cross-system meta-analysis reveals coupled predation effects on prey biomass and diversity

Oikos ◽  
2015 ◽  
Vol 124 (11) ◽  
pp. 1427-1435 ◽  
Author(s):  
Izumi Katano ◽  
Hideyuki Doi ◽  
Britas Klemens Eriksson ◽  
Helmut Hillebrand
Keyword(s):  
Meta Analysis ◽  
Prey Biomass ◽  
Predation Effects ◽  
Cross System

scholarly journals A meta-analysis of relationships between polychlorinated biphenyl exposure and performance across studies of free-ranging tree swallows ( Tachycineta bicolor )

2016 ◽  
Vol 3 (4) ◽  
pp. 150634 ◽  
Author(s):  
Frances Bonier
Keyword(s):  
Reproductive Success ◽  
Polychlorinated Biphenyl ◽  
Meta Analysis ◽  
Field Studies ◽  
Tree Swallow ◽  
Tree Swallows ◽  
Bioindicator Species ◽  
And Performance ◽  
Free Ranging ◽  
Pcb Exposure

Habitats worldwide are increasingly being degraded by human activities, with environmental pollution representing a significant threat to species and ecosystems. The presence of persistent organic chemicals, such as polychlorinated biphenyls (PCBs), has generated concern. Captive experiments and field studies have reported some evidence for detrimental effects of PCB exposure, but also significant variation across studies and species. Here, I use a meta-analytical approach to combine findings across 10 studies investigating effects of PCBs on performance (e.g. reproductive success, offspring growth) in free-ranging tree swallows, a common bioindicator species that accumulates high levels of PCBs at some contaminated sites. Contrary to predictions, five complementary analyses revealed no significant negative association between PCB exposure and performance in tree swallows. In fact, in one analysis, increased PCB exposure was associated with improved reproductive success. Possible explanations for these findings include several limitations of field studies, variation in the toxicity of different PCB congener mixtures found across sites included in the analysis, and variation in the degree of tolerance of PCB exposure among species (with high tolerance found in tree swallows). At this point, the available evidence from field studies does not demonstrate negative impacts of PCB exposure on tree swallow performance.

scholarly journals Environmental Polychlorinated Biphenyl Exposure and Breast Cancer Risk: A Meta-Analysis of Observational Studies

PLoS ONE ◽  
2015 ◽  
Vol 10 (11) ◽  
pp. e0142513 ◽  
Author(s):  
Jingwen Zhang ◽  
Yue Huang ◽  
Xiaoling Wang ◽  
Kun Lin ◽  
Kusheng Wu
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Observational Studies ◽  
Polychlorinated Biphenyl ◽  
Meta Analysis

Fine Structural Alterations in Thyroid Follicular Cells (FC) and Changes in Serum Thyroxine Produced by Feeding Polychlorinated Biphenyl (PCB) to Rats

1977 ◽  
Vol 35 ◽  
pp. 498-499
Author(s):  
W.T. Collins ◽  
Charles C. Capen ◽  
Louis Kasza
Keyword(s):  
Feed Efficiency ◽  
Polychlorinated Biphenyl ◽  
Serum Proteins ◽  
Skin Lesions ◽  
Hepatic Necrosis ◽  
Ultrastructural Changes ◽  
Lymphoid Tissues ◽  
Heat Transfer Fluids ◽  
Thyroid Follicular Cells ◽  
Peripheral Metabolism

The widespread contamination of the environment with PCB, a compound used extensively by industry in hydraulic and heat transfer fluids as well as plasticizers and solvents in adhesives and sealants, has resulted in detectable tissue levels in a large portion of the human population, domestic animals, and wildlife. Intoxication with PCB produces severe hepatic necrosis, degeneration of lymphoid tissues and kidney, skin lesions, decreased reproductive performance, reduced feed efficiency, and decreased weight gain. PCB also has been reported to reduce the binding of thyroid hormone to serum proteins and enhance the peripheral metabolism of thyroxine with increased excretion of thyroxine-glucuronide in the bile (Bastomsky, Endocrinology 95: 1150-1155, 1974).The objectives of this investigation were (1) to investigate the histopathologic, histochemical, and ultrastructural changes in thyroid FC produced by the acute (4 week) and chronic (12 week) administration of low (50 ppm) and high (500 ppm) doses of PCB to rats, (2) to correlate these alterations to changes in serum immunoreactive thyroxine concentration, and (3) to investigate the persistence of the effects of PCB on the thyroid gland.

Polychlorinated biphenyl induced hepatocyte alterations

1987 ◽  
Vol 45 ◽  
pp. 716-717
Author(s):  
D.N. Collins ◽  
J.N. Turner ◽  
K.O. Brosch ◽  
R.F. Seegal
Keyword(s):  
Lipid Droplets ◽  
Wistar Rats ◽  
Homovanillic Acid ◽  
Polychlorinated Biphenyl ◽  
Corn Oil ◽  
Environmental Pollutants ◽  
Short Term ◽  
Pcb Congeners ◽  
Urinary Levels ◽  
The Brain

Polychlorinated biphenyls (PCBs) are a ubiquitous class of environmental pollutants with toxic and hepatocellular effects, including accumulation of fat, proliferated smooth endoplasmic recticulum (SER), and concentric membrane arrays (CMAs) (1-3). The CMAs appear to be a membrane storage and degeneration organelle composed of a large number of concentric membrane layers usually surrounding one or more lipid droplets often with internalized membrane fragments (3). The present study documents liver alteration after a short term single dose exposure to PCBs with high chlorine content, and correlates them with reported animal weights and central nervous system (CNS) measures. In the brain PCB congeners were concentrated in particular regions (4) while catecholamine concentrations were decreased (4-6). Urinary levels of homovanillic acid a dopamine metabolite were evaluated (7).Wistar rats were gavaged with corn oil (6 controls), or with a 1:1 mixture of Aroclor 1254 and 1260 in corn oil at 500 or 1000 mg total PCB/kg (6 at each level).

The effects of low-ratio n-6/n-3 PUFA on biomarkers of inflammation: a systematic review and meta-analysis

2021 ◽  
Author(s):  
Yali Wei ◽  
Yan Meng ◽  
Na Li ◽  
Qian Wang ◽  
Liyong Chen
Keyword(s):  
Systematic Review ◽  
Fatty Acid ◽  
Polyunsaturated Fatty Acid ◽  
Meta Analysis ◽  
Chain Polyunsaturated Fatty Acid ◽  
Inflammation Markers ◽  
Pufa Supplementation ◽  
Long Chain

The purpose of the systematic review and meta-analysis was to determine if low-ratio n-6/n-3 long-chain polyunsaturated fatty acid (PUFA) supplementation affects serum inflammation markers based on current studies.

Noise-Induced Balance Loss? Rethinking Clinical Implications of Noise Exposure

2019 ◽  
Vol 4 (6) ◽  
pp. 1418-1422
Author(s):  
Bre Myers ◽  
J. Andrew Dundas
Keyword(s):  
Vestibular System ◽  
Noise Exposure ◽  
Balance Control ◽  
Scope Of Practice ◽  
Hearing Conservation ◽  
Exposed Population ◽  
Auditory Systems ◽  
Current Article ◽  
Balance Loss ◽  
Cross System

Purpose The primary aim of the current article is to provide a brief review of the literature regarding the effects of noise exposure on the vestibular and balance control systems. Although the deleterious effects of noise on the auditory system are widely known and continue to be an active area of research, much less is known regarding the effects of noise on the peripheral vestibular system. Audiologists with working knowledge of how both systems interact and overlap are better prepared to provide comprehensive care to more patients as assessment of both the auditory and vestibular systems has been in the audiologists' scope of practice since 1992. Method A narrative review summarizes salient findings from the archival literature. Results Temporary and permanent effects on vestibular system function have been documented in multiple studies. Hearing conservation, vestibular impairment, and fall risk reduction may be more intimately related than previously considered. Conclusions A full appreciation of both the vestibular and auditory systems is necessary to address the growing and aging noise-exposed population. More cross-system studies are needed to further define the complex relationship between the auditory and vestibular systems to improve comprehensive patient care.

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