Adipogenic Activity of Oligomeric Hexafluoropropylene Oxide (Perfluorooctanoic Acid Alternative) through Peroxisome Proliferator-Activated Receptor γ Pathway

2019 ◽  
Vol 53 (6) ◽  
pp. 3287-3295 ◽  
Author(s):  
Chuan-Hai Li ◽  
Xiao-Min Ren ◽  
Liang-Hong Guo
Keyword(s):  
Perfluorooctanoic Acid ◽  
Peroxisome Proliferator ◽  
Peroxisome Proliferator Activated Receptor ◽  
Hexafluoropropylene Oxide

scholarly journals Perfluorooctanoic Acid Induces Liver and Serum Dyslipidemia in Humanized PPARα Mice Fed an American Diet

2021 ◽  
Author(s):  
Jennifer J. Schlezinger ◽  
Tuulia Hyotylainen ◽  
Tim Sinioja ◽  
Catherine Boston ◽  
Hannah Puckett ◽  
...  
Keyword(s):  
Serum Concentration ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Perfluorooctanoic Acid ◽  
Null Point ◽  
Peroxisome Proliferator ◽  
Low Density ◽  
Dependent Manner ◽  
Peroxisome Proliferator Activated Receptor ◽  
Total Liver

Per- and polyfluoroalkyl substances (PFAS) are pervasive in the environment resulting in nearly universal detection in people. Human serum PFAS concentrations are strongly associated with increased serum low-density lipoprotein cholesterol (LDL-C), and growing evidence suggests an association with serum triacylglycerides (TG). Here, we tested the hypothesis that perfluorooctanoic acid (PFOA) dysregulates liver and serum triacylglycerides in human peroxisome proliferator activated receptor α (hPPAR α)-expressing mice fed an American diet. Mice were exposed to PFOA (3.3 mg/l) in drinking water for 6 weeks resulting in a serum concentration of 48 ± 9 μg/ml. In male and female hPPAR α mice, PFOA increased total liver TG and TG substituted with saturated and monounsaturated fatty acids. Lack of expression of hPPARα alone also increased total liver TG, and PFOA treatment had little effect on liver TG in null mice. In hPPARα mice, PFOA neither significantly increased nor decreased serum TG; however, there was a modest increase in TG associated with very low-density cholesterol particles in both sexes. Across studies, a non-monotonic effect of PFOA on serum TG is evident, with the serum PFOA concentration in this study falling near the null point between increasing and decreasing serum TG. Intriguingly, in female PPARα null mice, PFOA significantly increased serum TG, with a similar trend in males. PFOA also modified fatty acid and TG homeostasis-related gene expression in liver, in a hPPARα-dependent manner, but not in adipose. The results reveal the importance of context (serum concentration and genotype) in determining the effect of PFOA on lipid homeostasis.

scholarly journals A Species Difference in the Peroxisome Proliferator-Activated Receptor α-Dependent Response to the Developmental Effects of Perfluorooctanoic Acid

2012 ◽  
Vol 131 (2) ◽  
pp. 568-582 ◽  
Author(s):  
Prajakta P. Albrecht ◽  
Nicole E. Torsell ◽  
Prasad Krishnan ◽  
David J. Ehresman ◽  
Steven R. Frame ◽  
...  
Keyword(s):  
Species Difference ◽  
Perfluorooctanoic Acid ◽  
Peroxisome Proliferator ◽  
Peroxisome Proliferator Activated Receptor ◽  
Developmental Effects
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