Human CYP2A6, CYP2B6, AND CYP2E1 Atropselectively Metabolize Polychlorinated Biphenyls to Hydroxylated Metabolites

Eric Uwimana; Patricia Ruiz; Xueshu Li; Hans-Joachim Lehmler

doi:10.1021/acs.est.8b05250

Human CYP2A6, CYP2B6, AND CYP2E1 Atropselectively Metabolize Polychlorinated Biphenyls to Hydroxylated Metabolites

Environmental Science & Technology ◽

10.1021/acs.est.8b05250 ◽

2018 ◽

Vol 53 (4) ◽

pp. 2114-2123 ◽

Cited By ~ 11

Author(s):

Eric Uwimana ◽

Patricia Ruiz ◽

Xueshu Li ◽

Hans-Joachim Lehmler

Keyword(s):

Polychlorinated Biphenyls ◽

Hydroxylated Metabolites

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Inhibition of thyroid hormone sulfation by hydroxylated metabolites of polychlorinated biphenyls

Chemico-Biological Interactions ◽

10.1016/s0009-2797(97)00140-3 ◽

1998 ◽

Vol 109 (1-3) ◽

pp. 293-297 ◽

Cited By ~ 47

Author(s):

A Gerlienke Schuur ◽

Abraham Brouwer ◽

Åke Bergman ◽

Michael W.H Coughtrie ◽

Theo J Visser

Keyword(s):

Thyroid Hormone ◽

Polychlorinated Biphenyls ◽

Hydroxylated Metabolites

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Effects of Polychlorinated Biphenyls (PCBs) and Their Hydroxylated Metabolites (OH-PCBs) on Arabidopsis thaliana

Environmental Science & Technology ◽

10.1021/acs.est.7b01538 ◽

2017 ◽

Vol 51 (12) ◽

pp. 7263-7270 ◽

Cited By ~ 13

Author(s):

Srishty Subramanian ◽

Jerald L. Schnoor ◽

Benoit Van Aken

Keyword(s):

Arabidopsis Thaliana ◽

Polychlorinated Biphenyls ◽

Hydroxylated Metabolites

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Prenatal Exposure to Polychlorinated Biphenyls and Their Hydroxylated Metabolites is Associated with Neurological Functioning in 3-Month-Old Infants

Toxicological Sciences ◽

10.1093/toxsci/kfu196 ◽

2014 ◽

Vol 142 (2) ◽

pp. 455-462 ◽

Cited By ~ 21

Author(s):

Sietske A. Berghuis ◽

Shalini D. Soechitram ◽

Pieter J.J. Sauer ◽

Arend F. Bos

Keyword(s):

Polychlorinated Biphenyls ◽

Prenatal Exposure ◽

Hydroxylated Metabolites ◽

Neurological Functioning

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Influence of polychlorinated biphenyls and their hydroxylated metabolites on prostaglandins secretion from epithelial cells of bovine oviduct, in vitro

Toxicology ◽

10.1016/j.tox.2010.01.018 ◽

2010 ◽

Vol 270 (2-3) ◽

pp. 85-91 ◽

Cited By ~ 8

Author(s):

Michal H. Wrobel ◽

Jaroslaw Mlynarczuk ◽

Jan Kotwica

Keyword(s):

Epithelial Cells ◽

Polychlorinated Biphenyls ◽

Hydroxylated Metabolites

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Blood levels of polychlorinated biphenyls and their hydroxylated metabolites in Baikal seals (Pusa sibirica): Emphasis on interspecies comparison, gender difference and association with blood thyroid hormone levels

Chemosphere ◽

10.1016/j.chemosphere.2014.03.089 ◽

2014 ◽

Vol 114 ◽

pp. 1-8 ◽

Cited By ~ 14

Author(s):

Daisuke Imaeda ◽

Kei Nomiyama ◽

Tatsuya Kunisue ◽

Hisato Iwata ◽

Oyuna Tsydenova ◽

...

Keyword(s):

Thyroid Hormone ◽

Gender Difference ◽

Polychlorinated Biphenyls ◽

Blood Levels ◽

Interspecies Comparison ◽

Hormone Levels ◽

Hydroxylated Metabolites ◽

Thyroid Hormone Levels

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Atropisomeric determination of chiral hydroxylated metabolites of polychlorinated biphenyls using HPLC-MS

Chemistry Central Journal ◽

10.1186/1752-153x-7-183 ◽

2013 ◽

Vol 7 (1) ◽

Cited By ~ 15

Author(s):

Guangshu Zhai ◽

Xianai Wu ◽

Hans-Joachim Lehmler ◽

Jerald L Schnoor

Keyword(s):

Polychlorinated Biphenyls ◽

Hydroxylated Metabolites

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Assessment of hydroxylated metabolites of polychlorinated biphenyls as potential xenoestrogens: a QSAR comparative analysis∗

SAR and QSAR in Environmental Research ◽

10.1080/1062936x.2013.781537 ◽

2013 ◽

Vol 24 (5) ◽

pp. 393-416 ◽

Cited By ~ 12

Author(s):

P. Ruiz ◽

E. Myshkin ◽

P. Quigley ◽

O. Faroon ◽

J.S. Wheeler ◽

...

Keyword(s):

Comparative Analysis ◽

Polychlorinated Biphenyls ◽

Hydroxylated Metabolites

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Polychlorinated biphenyls and their hydroxylated metabolites in the serum of e-waste dismantling workers from eastern China

Environmental Geochemistry and Health ◽

10.1007/s10653-017-9958-x ◽

2017 ◽

Vol 40 (5) ◽

pp. 1931-1940 ◽

Cited By ~ 10

Author(s):

Shengtao Ma ◽

Guofa Ren ◽

Xiangying Zeng ◽

Zhiqiang Yu ◽

Guoying Sheng ◽

...

Keyword(s):

Polychlorinated Biphenyls ◽

Eastern China ◽

Hydroxylated Metabolites

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Serum polychlorinated biphenyls and their hydroxylated metabolites are associated with demographic and behavioral factors in children and mothers

Environment International ◽

10.1016/j.envint.2016.06.014 ◽

2016 ◽

Vol 94 ◽

pp. 538-545 ◽

Cited By ~ 9

Author(s):

Wen Xin Koh ◽

Keri C. Hornbuckle ◽

Kai Wang ◽

Peter S. Thorne

Keyword(s):

Polychlorinated Biphenyls ◽

Behavioral Factors ◽

Hydroxylated Metabolites

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Chiral Polychlorinated Biphenyls Are Biotransformed Enantioselectively by Mammalian Cytochrome P-450 Isozymes to Form Hydroxylated Metabolites

Environmental Science & Technology ◽

10.1021/es802237u ◽

2009 ◽

Vol 43 (1) ◽

pp. 114-121 ◽

Cited By ~ 63

Author(s):

Nicholas A. Warner ◽

Jonathan W. Martin ◽

Charles S. Wong

Keyword(s):

Polychlorinated Biphenyls ◽

Hydroxylated Metabolites ◽

Chiral Polychlorinated Biphenyls ◽

Cytochrome P 450

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