Effect-Directed Analysis of Toxicants in Sediment with Combined Passive Dosing and in Vivo Toxicity Testing

2017 ◽  
Vol 51 (11) ◽  
pp. 6414-6421 ◽  
Author(s):  
Hongxue Qi ◽  
Huizhen Li ◽  
Yanli Wei ◽  
W. Tyler Mehler ◽  
Eddy Y. Zeng ◽  
...  
Keyword(s):  
Toxicity Testing ◽  
In Vivo Toxicity ◽  
Passive Dosing ◽  
Effect Directed Analysis

scholarly journals An Integrative Evaluation Method for the Biological Safety of Down and Feather Materials

2019 ◽  
Vol 20 (6) ◽  
pp. 1434 ◽  
Author(s):  
Toshikatsu Kawada ◽  
Junya Kuroyanagi ◽  
Fumiyoshi Okazaki ◽  
Mizuki Taniguchi ◽  
Hiroko Nakayama ◽  
...  
Keyword(s):  
Bacterial Contamination ◽  
Evaluation Method ◽  
Toxicity Testing ◽  
Chemical Additives ◽  
Chemical Contaminants ◽  
In Vivo Toxicity ◽  
Chemical Treatments ◽  
Integrative Evaluation ◽  
Embryo Toxicity

Background: Down and feather materials have been commonly used and promoted as natural stuffing for warm clothing and bedding. These materials tend to become more allergenic as they become contaminated with microorganisms, in addition to being subjected to several kinds of chemical treatments. The biological or chemical contaminants in these materials pose a major risk to human health, to consumers and manufacturers alike. Here, we report the development of an integrative evaluation method for down and feather materials to assess bacterial contamination and in vivo toxicity. Methods: To assess bacterial contamination, we quantified 16S ribosomal RNA, performed culture tests, and established a conversion formula. To determine in vivo toxicity, we performed a zebrafish embryo toxicity testing (ZFET). Results: Washing the material appropriately decreases the actual number of bacteria in the down and feather samples; in addition, after washing, 16S rRNA sequencing revealed that the bacterial compositions were similar to those in rinse water. The ZFET results showed that even materials with low bacterial contamination showed high toxicity or high teratogenicity, probably because of the presence of unknown chemical additives. Conclusions: We established an integrative evaluation method for down and feather safety, based on bacterial contamination with in vivo toxicity testing.

IN VIVO TOXICITY TESTING OF METHYL BLUE AND ANILINE BLUE AS VITAL DYES FOR INTRAOCULAR SURGERY

Retina ◽  
2009 ◽  
Vol 29 (9) ◽  
pp. 1257-1265 ◽  
Author(s):  
SEBASTIAN THALER ◽  
FRANK SCHUETTAUF ◽  
MICHAL FIEDOROWICZ ◽  
ANDRE MESSIAS ◽  
ANDREAS SCHATZ ◽  
...  
Keyword(s):  
Toxicity Testing ◽  
Methyl Blue ◽  
Aniline Blue ◽  
In Vivo Toxicity ◽  
Intraocular Surgery ◽  
Vital Dyes

scholarly journals Screening of toxic potential of graphene family nanomaterials using in vitro and alternative in vivo toxicity testing systems

2015 ◽  
Vol 30 ◽  
pp. e2015007 ◽  
Author(s):  
Nivedita Chatterjee ◽  
Ji Su Yang ◽  
Kwangsik Park ◽  
Seung Min Oh ◽  
Jeonggue Park ◽  
...  
Keyword(s):  
Toxicity Testing ◽  
In Vivo Toxicity ◽  
Toxic Potential

scholarly journals Galleria mellonella: The Versatile Host for Drug Discovery, In Vivo Toxicity Testing and Characterising Host-Pathogen Interactions

Antibiotics ◽  
2021 ◽  
Vol 10 (12) ◽  
pp. 1545
Author(s):  
Magdalena Piatek ◽  
Gerard Sheehan ◽  
Kevin Kavanagh
Keyword(s):  
Antimicrobial Agents ◽  
Galleria Mellonella ◽  
Toxicity Testing ◽  
In Vivo Model ◽  
Ethical Considerations ◽  
Food Preservatives ◽  
In Vivo Toxicity ◽  
Greater Wax Moth ◽  
Development Processes

Larvae of the greater wax moth, Galleria mellonella, are a convenient in vivo model for assessing the activity and toxicity of antimicrobial agents and for studying the immune response to pathogens and provide results similar to those from mammals. G. mellonella larvae are now widely used in academia and industry and their use can assist in the identification and evaluation of novel antimicrobial agents. Galleria larvae are inexpensive to purchase and house, easy to inoculate, generate results within 24–48 h and their use is not restricted by legal or ethical considerations. This review will highlight how Galleria larvae can be used to assess the efficacy of novel antimicrobial therapies (photodynamic therapy, phage therapy, metal-based drugs, triazole-amino acid hybrids) and for determining the in vivo toxicity of compounds (e.g., food preservatives, ionic liquids) and/or solvents (polysorbate 80). In addition, the disease development processes are associated with a variety of pathogens (e.g., Staphylococcus aureus, Listeria monocytogenes, Aspergillus fumigatus, Madurella mycotomatis) in mammals are also present in Galleria larvae thus providing a simple in vivo model for characterising disease progression. The use of Galleria larvae offers many advantages and can lead to an acceleration in the development of novel antimicrobials and may be a prerequisite to mammalian testing.

In Vivo Toxicity Testing

2021 ◽  
pp. 142-155
Author(s):  
Carmen González-Martín ◽  
Esther Gramage ◽  
María José Polanco ◽  
Carmen Rodríguez-Rivera
Keyword(s):  
Toxicity Testing ◽  
In Vivo Toxicity

scholarly journals PRODUCTION AND IN VIVO TOXICITY TESTING OF MICROCRYSTALLINE CELLULOSE DERIVED FROM BACTERIAL CELLULOSE

Human Ecology ◽  
2018 ◽  
pp. 21-25
Author(s):  
К. S. Bolotova ◽  
O. V. Buyuklinskaya ◽  
А. S. Chistyakova ◽  
О. V. Travina ◽  
D. G. Chukhchin
Keyword(s):  
Bacterial Cellulose ◽  
Microcrystalline Cellulose ◽  
Toxicity Testing ◽  
In Vivo Toxicity

NT4X-167; Novel N-terminal Aβ specific antibody, prevents in vitro and in vivo toxicity of highly toxic Aβ4-42 species

2015 ◽  
Vol 48 (06) ◽  
Author(s):  
G Antonios ◽  
H Borgers ◽  
T Pilot ◽  
V Pena ◽  
T Bayer
Keyword(s):  
Specific Antibody ◽  
In Vivo Toxicity

Negative cross resistance of Spodoptera litura Fabricius population of tomato to newer molecule spinetoram

ENTOMON ◽  
2019 ◽  
Vol 44 (2) ◽  
pp. 127-132
Author(s):  
M. Visnupriya ◽  
N. Muthukrishnan
Keyword(s):  
Spodoptera Litura ◽  
Laboratory Strain ◽  
Field Population ◽  
Resistance Ratio ◽  
Cross Resistance ◽  
In Vivo Toxicity

Field population of Spodoptera litura from tomato ( resistant to the majority of the conventional insecticide molecules) were subjected to the in vivo toxicity of spinetoram 12 SC to assess whether cross resistance exists or not. Untreated larvae of both field and laboratory strains showed no mortality during 48 hours of feeding. After 48 hours of feeding on spinetoram 12 SC treated leaves, LC50s of field larvae were 0.28, 0.93, 3.71 and 7.11 ppm for the 2nd, 3rd, 4th and 5th instars of S. litura respectively. However, in the laboratory strain these values were 1.12, 5.86, 36.72 and 91.55 ppm for 2nd, 3rd, 4th and 5th instars of S. litura respectively. Resistance ratio was 0.25, 0.16, 0.10 and 0.08 for the 2nd instar up to the 5th instar of S. litura.

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