scholarly journals Environmental Photochemistry of Altrenogest: Photoisomerization to a Bioactive Product with Increased Environmental Persistence via Reversible Photohydration

2016 ◽  
Vol 50 (14) ◽  
pp. 7480-7488 ◽  
Author(s):  
Kristine H. Wammer ◽  
Kyler C. Anderson ◽  
Paul R. Erickson ◽  
Sarah Kliegman ◽  
Marianna E. Moffatt ◽  
...  
Keyword(s):  
Environmental Persistence ◽  
Bioactive Product ◽  
Environmental Photochemistry

Correction to Environmental Photochemistry of Altrenogest: Photoisomerization to a Bioactive Product with Increased Environmental Persistence via Reversible Photohydration

2016 ◽  
Vol 50 (18) ◽  
pp. 10292-10292 ◽  
Author(s):  
Kristine H. Wammer ◽  
Kyler C. Anderson ◽  
Paul R. Erickson ◽  
Sarah Kliegman ◽  
Marianna E. Moffatt ◽  
...  
Keyword(s):  
Environmental Persistence ◽  
Bioactive Product ◽  
Environmental Photochemistry

Environmental photochemistry of dienogest: phototransformation to estrogenic products and increased environmental persistence via reversible photohydration

2017 ◽  
Vol 19 (11) ◽  
pp. 1414-1426 ◽  
Author(s):  
Nicholas C. Pflug ◽  
Madeline K. Hankard ◽  
Stephanie M. Berg ◽  
Meghan O'Connor ◽  
James B. Gloer ◽  
...  
Keyword(s):  
Environmental Persistence ◽  
Environmental Photochemistry

Reversible photohydration of dienogest also yields estrogenic byproducts.

scholarly journals IMPROVING OUR UNDERSTANDING OF THE ENVIRONMENTAL PERSISTENCE OF CHEMICALS

2021 ◽  
Author(s):  
Graham Whale ◽  
John Parsons ◽  
Kees Ginkel ◽  
Russell Davenport ◽  
Eleni Vaiopoulou ◽  
...  
Keyword(s):  
Environmental Persistence

scholarly journals Extracellular amoebal-vesicles: potential transmission vehicles for respiratory viruses

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Rafik Dey ◽  
Melanie A. Folkins ◽  
Nicholas J. Ashbolt
Keyword(s):  
Respiratory Syncytial Virus ◽  
Respiratory Tract ◽  
Respiratory Tract Infections ◽  
Respiratory Viruses ◽  
Environmental Persistence ◽  
Viral Dissemination ◽  
Acute Respiratory Tract Infections ◽  
High Concentrations ◽  
Syncytial Virus ◽  
Tract Infections

AbstractHuman respiratory syncytial virus (RSV) is a major cause of acute respiratory tract infections in children and immunocompromised adults worldwide. Here we report that amoebae-release respirable-sized vesicles containing high concentrations of infectious RSV that persisted for the duration of the experiment. Given the ubiquity of amoebae in moist environments, our results suggest that extracellular amoebal-vesicles could contribute to the environmental persistence of respiratory viruses, including potential resistance to disinfection processes and thereby offering novel pathways for viral dissemination and transmission.

scholarly journals Methodological Advances to Study Contaminant Biotransformation: New Prospects for Understanding and Reducing Environmental Persistence?

2021 ◽  
Author(s):  
Kathrin Fenner ◽  
Martin Elsner ◽  
Tillmann Lueders ◽  
Michael S. McLachlan ◽  
Lawrence P. Wackett ◽  
...  
Keyword(s):  
Environmental Persistence

Enantioselective analysis and fate of polycyclic musks in a water recycling plant in Sydney (Australia)

2014 ◽  
Vol 69 (10) ◽  
pp. 1996-2003 ◽  
Author(s):  
L. Wang ◽  
S. J. Khan
Keyword(s):  
Municipal Wastewater ◽  
High Sensitivity ◽  
Environmental Chemicals ◽  
Water Recycling ◽  
Environmental Persistence ◽  
Enantioselective Analysis ◽  
Treatment Processes ◽  
Polycyclic Musks ◽  
Household Products ◽  
Final Effluent

Synthetic polycyclic musks (PCMs) Galaxolide (HHCB), Tonalide (AHTN), Phantolide (AHDI), Traseolide (ATII) and Cashmeran (DPMI) are chiral chemicals that are commonly used in washing product industries as racemic mixtures. The major source of PCMs in municipal wastewater is from personal care and household products. Recent studies have shown that PCMs may enhance the relative toxicity of other environmental chemicals by inhibiting cellular xenobiotic defence systems. High sensitivity enantioselective analysis of these compounds enables improved characterisation of the environmental persistence and fate of PCMs, distinguishing between individual enantiomers so that a more complete understanding of environmental risks tributed by individual enantiomers may be obtained. Concentrations of PCMs through the various treatment stages of an advanced water recycling plant in Sydney were investigated to assess the removal of these chemicals. Average concentrations of HHCB, AHTN, AHDI, ATII and DPMI in influent were: 2,545, 301, 2, 5 and 33 ng L−1, respectively. In the final effluent, AHDI, ATII and DPMI were not detected, while HHCB and AHTN were still measured at concentrations of 21 and 2 ng L−1. No significant enantioselective transformation was detected during biological or advanced treatment processes.

Plasma levels of bigEndothelin-1 are associated with renal insufficiency and in-hospital mortality of immune thrombotic thrombocytopenic purpura

2021 ◽  
Author(s):  
Ruinan Lu ◽  
X. Long Zheng
Keyword(s):  
Hospital Mortality ◽  
Thrombotic Thrombocytopenic Purpura ◽  
Plasma Levels ◽  
Thrombus Formation ◽  
Microfluidic Channel ◽  
Thrombocytopenic Purpura ◽  
Severe Deficiency ◽  
Bioactive Product ◽  
First Time

Immune thrombotic thrombocytopenic purpura (iTTP) is caused by severe deficiency of plasma ADAMTS13 activity. Despite advances in early diagnosis and management, the mortality rate of acute iTTP remains high in a large part of world where access to some of the most novel therapies is limited. To determine the role of plasma bigEndothelin-1 (bigET-1) or its bioactive product ET-1 as a biomarker and/or a pathogenic factor in acute iTTP, plasma levels of bigET-1 were determined using an immunoassay in patients with iTTP on admission and during remission, as well as in healthy controls; moreover, the biological effect of ET-1 in thrombus formation was determined by a microfluidic assay. We show that plasma levels of bigET-1 were dramatically increased in patients with acute iTTP on admission, which was significantly decreased during clinical response/remission; elevated admission levels of plasma bigET-1 were associated with low estimated glomerular filtration rate, the need for intensive care unit admission or intubation, and in-hospital mortality. Moreover, an addition of a bioactive product ET-1 to cultured endothelial cells in a microfluidic channel dramatically accelerated the rate of thrombus formation under arterial flow. Our results demonstrate for the first time a potential role of measuring plasma bigET-1 in patients with acute iTTP in assessing the disease severity and risk of in-hospital mortality, which may help stratify patients for a more aggressive monitoring and therapeutic strategy; also, the bioactive ET-1, derived from bigET-1, may result in acute renal injury in TTP patient, likely through its vasoconstriction and prothrombotic properties.

Zebrafish embryos exposed to deltamethrin exhibit abnormalities despite induced expression of related genes (you, you-too, momo and u-boot)

2018 ◽  
Vol 35 (1) ◽  
pp. 11-19
Author(s):  
Kuder Reshma Shabnam ◽  
Dharmapuri Gangappa ◽  
Gundala Harold Philip
Keyword(s):  
Vital Role ◽  
Primary Objective ◽  
Chain Reaction ◽  
Environmental Persistence ◽  
Expression Of Genes ◽  
Pericardial Edema ◽  
Eye Pigmentation ◽  
Polymerase Chain ◽  
Relationship Of ◽  
The Relationship

Evaluation of the toxic effects of a widely used synthetic pyrethroid, deltamethrin (DM), was carried out in this study. This pesticide is preferred for pest control because of its low environmental persistence and toxicity. We investigated the expression pattern of four genes, namely, you ( you), yot ( you-too), momo ( mom) and ubo ( u-boot) during early development of zebrafish, that is, from 12 hpf to 48 hpf stages. These stages are selected as most of the important developmental aspects take place during this period. All four genes are known to play a vital role in development of notochord and somites. To understand the effect of DM on development, embryos of 4 hpf stage were exposed to two concentrations (100 and 200 µg/L) of DM, and observations were made at 12, 24 and 48 hpf stages. Our earlier studies have shown phenotypic abnormalities such as notochord bending, tail deformation, yolk sac and pericardial edema, lightening of body and eye pigmentation and interfered in somite patterning, during these stages of development. Understanding the relationship of phenotypic abnormalities with these four genes has been our primary objective. These four genes were analyzed by Reverse transcription (RT)-polymerase chain reaction and intensity of the bands has shown induction in their expression after exposure to the toxicant. In spite of the expression of genes, it was noticed that DM caused abnormalities. It can be said from the results that translational pathway could have been affected.

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