scholarly journals Urinary Metabolites of Polycyclic Aromatic Hydrocarbons and the Association with Lipid Peroxidation: A Biomarker-Based Study between Los Angeles and Beijing

2016 ◽  
Vol 50 (7) ◽  
pp. 3738-3745 ◽  
Author(s):  
Yan Lin ◽  
Xinghua Qiu ◽  
Nu Yu ◽  
Qiaoyun Yang ◽  
Jesus A. Araujo ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Polycyclic Aromatic Hydrocarbons ◽  
Los Angeles ◽  
Aromatic Hydrocarbons ◽  
Urinary Metabolites ◽  
Polycyclic Aromatic

Urinary metabolites of polycyclic aromatic hydrocarbons in workers exposed to vapours and aerosols of bitumen

2011 ◽  
Vol 85 (S1) ◽  
pp. 29-39 ◽  
Author(s):  
Beate Pesch ◽  
Anne Spickenheuer ◽  
Benjamin Kendzia ◽  
Birgit Karin Schindler ◽  
Peter Welge ◽  
...  
Keyword(s):  
Polycyclic Aromatic Hydrocarbons ◽  
Aromatic Hydrocarbons ◽  
Urinary Metabolites ◽  
Polycyclic Aromatic

scholarly journals A study of the status of exposure to polycyclic aromatic hydrocarbons (PAHs) in relation to its metabolites among workers in a Korean chemical factory

2014 ◽  
Vol 19 (12) ◽  
pp. 4809-4818 ◽  
Author(s):  
Kwan Lee ◽  
Hyun-Sul Lim ◽  
Heon Kim
Keyword(s):  
Polycyclic Aromatic Hydrocarbons ◽  
Aromatic Hydrocarbons ◽  
Urinary Metabolites ◽  
Multiple Regression Model ◽  
Age Group ◽  
Worker Exposure ◽  
Chemical Factory ◽  
The Status ◽  
Polycyclic Aromatic ◽  
Male Subjects

The study was conducted to evaluate the status of worker exposure to polycyclic aromatic hydrocarbons (PAHs) through the measurement of urinary metabolites such as 1-hydroxypyrene (OHP) and 2-naphthol. A survey using a questionnaire involving 326 workers with measurement of urinary metabolites of 1-OHP and 2-naphthol was conducted. The differences in urinary 1-OHP and 2-naphthol concentrations, and changes in work, smoking habits and lifestyle were analyzed. The number of male subjects was 314 (96.3%), the largest age group was the fifth decade (170 cases, 52.1%). The urinary 1-OHP and 2-naphthol concentrations were significantly higher in the production workers. The urinary 1-OHP and 2-naphthol concentrations were significantly higher in smokers. In a multiple regression model, log (1-OHP) increased in smokers and production workers, while log (2-naphthol) only increased in smokers. Our results suggest that workers in this factory were exposed to PAHs from non-occupational as well as occupational sources. The occupational exposure to PAHs can be reduced through the improvement of the process, but the exposure due to smoking can be prevented only by giving up smoking.

Photoirradiation of representative polycyclic aromatic hydrocarbons and twelve isomeric methylbenz[a]anthracene with UVA light: formation of lipid peroxidation

2006 ◽  
Vol 22 (4) ◽  
pp. 147-156 ◽  
Author(s):  
Qingsu Xia ◽  
Ming W Chou ◽  
Jun J Yin ◽  
Paul C Howard ◽  
Hongtao Yu ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Polycyclic Aromatic Hydrocarbons ◽  
Free Radical ◽  
Methyl Linoleate ◽  
Aromatic Hydrocarbons ◽  
Lipid Peroxide ◽  
Free Radical Scavenger ◽  
Radical Scavenger ◽  
Uva Light ◽  
Polycyclic Aromatic

Polycyclic aromatic hydrocarbons (PAHs) are widespread genotoxic environmental pollutants, which require metabolic activation in order to exert biological activities, including mutagenicity and carcinogenicity. Photoactivation is another activation pathway that can lead to PAH genotoxicity. In this paper, we demonstrate that photoirradiation of a series of representative PAHs, with and without bearing a methyl substituent, with UVA light in the presence of methyl linoleate resulted in the formation of methyl linoleate hydroperoxides (a lipid peroxide). The lipid peroxide formation was inhibited by dithiothreitol (DTT) (free radical scavenger), NaN3 (singlet oxygen and free radical scavenger), and superoxide dismutase (SOD) (superoxide scavenger), but was enhanced by the presence of deuterium oxide (D2O) (extends singlet oxygen lifetime). These results suggest that photoirradiation of PAHs by UVA light generates reactive oxygen species (ROS), which induce lipid peroxidation.

scholarly journals Metagenomics and stable isotope probing offer insights into metabolism of polycyclic aromatic hydrocarbons degraders in chronically polluted seawater

2019 ◽  
Author(s):  
Ella T. Sieradzki ◽  
Michael Morando ◽  
Jed A. Fuhrman
Keyword(s):  
Polycyclic Aromatic Hydrocarbons ◽  
Los Angeles ◽  
Stable Isotope ◽  
Aromatic Hydrocarbons ◽  
Degradation Pathway ◽  
Stable Isotope Probing ◽  
Rrna Gene ◽  
Port Of Los Angeles ◽  
Polycyclic Aromatic ◽  
Bacterial Biodegradation

AbstractBacterial biodegradation is a significant contributor to remineralization of polycyclic aromatic hydrocarbons (PAHs): toxic and recalcitrant components of crude oil as well as byproducts of partial combustion chronically introduced into seawater via atmospheric deposition. The Deepwater Horizon oil spill demonstrated the speed at which a seed PAH-degrading community maintained by low chronic inputs can respond to an acute pollution. We investigated the diversity and functional potential of a similar seed community in the Port of Los Angeles, a chronically polluted site, using stable isotope probing with naphthalene, deep-sequenced metagenomes and carbon incorporation rate measurements at the port and in two sites further into the San Pedro Channel. We show a switch in the composition of the PAH degrading community from diverse early-responding generalists to late-blooming specialized degraders. This switch demonstrates the ability of the local seed community of degraders at the Port of LA to incorporate carbon from PAHs independently of a labile-hydrocarbon degrading succession. We were able to directly show that assembled genomes belonged to naphthalene degraders by matching their 16S-rRNA gene with experimental stable isotope probing data. Surprisingly, we did not find a full PAH degradation pathway in any of those genomes and even when combining genes from the entire microbial community. We use metabolic pathways identified in those genomes to generate metagenomic-based recommendations for future optimization of PAHs bioremediation.

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