Interactions of Anti-Inflammatory and Antibiotic Drugs at Mineral Surfaces Can Control Environmental Fate and Transport

2021 ◽  
Author(s):  
Tao Luo ◽  
Jing Xu ◽  
Wei Cheng ◽  
Lian Zhou ◽  
Rémi Marsac ◽  
...  
Keyword(s):  
Environmental Fate ◽  
Fate And Transport ◽  
Mineral Surfaces ◽  
Antibiotic Drugs ◽  
Anti Inflammatory

scholarly journals Therapeutic Hydrogel Lenses and the Antibacterial and Antibiotic Drugs Release

2021 ◽  
Vol 11 (4) ◽  
pp. 1931
Author(s):  
Alessandra Pulliero ◽  
Aldo Profumo ◽  
Camillo Rosano ◽  
Alberto Izzotti ◽  
Sergio Claudio Saccà
Keyword(s):  
Antibacterial Activity ◽  
Salmonella Typhimurium ◽  
Drug Availability ◽  
Silicone Hydrogel ◽  
Antibiotic Drugs ◽  
Medical Approach ◽  
Anti Inflammatory ◽  
Gradient Hplc

The aim of this research was to evaluate the effects of different lens types on the availability and efficacy of anti-inflammatory and antibiotic drugs. Three lens types were examined: (1) nonionic hydrogel lenses; (2) ionic hydrogel lenses; and (3) silicone hydrogel lenses. The lenses were incubated with (a) dexamethasone; (b) betamethasone; (c) bromophenacyl bromide; and (d) chloramphenicol. Drug availability was quantified by gradient HPLC, and chloramphenicol antibacterial activity was quantified by testing the inhibition of Salmonella typhimurium growth on agar. The lens allowing the most abundant passage of betamethasone was the ionic hydrogel lens, followed by the silicone hydrogel lens and nonionic hydrogel lens. The lens allowing the most abundant passage of dexamethasone was the ionic hydrogel lens, but only at 0.5 h and 1 h. Regarding chloramphenicol, the ionic hydrogel lens and silicone hydrogel lens allowed more abundant passage than the nonionic hydrogel lens. These results highlight the relevance of adapting lenses to anti-inflammatory therapy, thus allowing a personalized medical approach.

Environmental fate of non-steroidal anti-inflammatory drugs in river water/sediment systems

2017 ◽  
Vol 323 ◽  
pp. 233-241 ◽  
Author(s):  
Elena Koumaki ◽  
Daniel Mamais ◽  
Constantinos Noutsopoulos
Keyword(s):  
River Water ◽  
Environmental Fate ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

scholarly journals Effect of the Association of Nonsteroidal Anti-inflammatory and Antibiotic Drugs on Antibiofilm Activity and pH of Calcium Hydroxide Pastes

2017 ◽  
Vol 43 (1) ◽  
pp. 131-134 ◽  
Author(s):  
Rafaela Pignatti de Freitas ◽  
Vanessa Raquel Greatti ◽  
Murilo Priori Alcalde ◽  
Bruno Cavalini Cavenago ◽  
Rodrigo Ricci Vivan ◽  
...  
Keyword(s):  
Calcium Hydroxide ◽  
Antibiofilm Activity ◽  
Antibiotic Drugs ◽  
Anti Inflammatory

The use of Runoff and Surface Water Transport and Fate Models in the Pesticide Registration Process

1992 ◽  
Vol 6 (3) ◽  
pp. 743-748 ◽  
Author(s):  
Paul L. Zubkoff
Keyword(s):  
Surface Waters ◽  
Environmental Fate ◽  
Transport Model ◽  
Numerical Models ◽  
Chemical Properties ◽  
Chemical Characterization ◽  
Fate And Transport ◽  
Environmental Parameters ◽  
Field Studies ◽  
Chemical Application

In support of the registration and reregistration processes under FIFRA ‘88, numerical models are used to estimate the dissolved runoff and soil erosion loadings of pesticides to surface waters and the subsequent fate and transport of pesticides in the receiving waters. Uses for simulations include:1. Helping to determine whether additional studies on the fate and distribution of a candidate chemical in the environment and/or ecological effects may be needed when full chemical characterization is incomplete.2. Helping to more fully integrate data submissions of laboratory and field observations.3. Estimating probable fate and distribution of an agrochemical after a severe runoff event.4. Comparing alternative chemical application rates and methods for the same chemical/soil/crop/environmental combinations.5. Comparing different soil/crop/environmental combinations representing different geographical areas with the same chemical.6. Evaluating preliminary designs of proposed field studies.7. Gaining insight into the environmental fate of modern chemicals that are applied at 1 to 2% of the rates of older chemicals when sampling designs and analytical methods are not available.The Office of Pesticide Programs (OPP) commonly employs the SWRRB (45, 46) and PRZM (8, 9) models for runoff and EXAMS II (5), a fate and transport model, for surface waters. These three models are used in conjunction with appropriate databases for soils, chemical properties, and meteorological and other environmental parameters. Registrants are encouraged to clearly state assumptions, identify values for parameters by citation, report results of simulations with summary tables and graphics, and interpret their results in relation to current scientific disciplines.

Sign in / Sign up

Export Citation Format

Share Document