Selected Mechanistic Aspects of Viral Inactivation by Peracetic Acid

The Activity of Peracetic Acid on Sewage Indicator Bacteria and Viruses

Water Science & Technology ◽

10.2166/wst.1991.0089 ◽

1991 ◽

Vol 24 (2) ◽

pp. 353-357 ◽

Cited By ~ 43

Author(s):

M. G. C. Baldry ◽

M. S. French ◽

D. Slater

Keyword(s):

Organic Matter ◽

Sodium Hypochlorite ◽

Yeast Extract ◽

Peracetic Acid ◽

Indicator Bacteria ◽

Laboratory Studies ◽

Viral Inactivation ◽

Effective Agent ◽

Experimental Systems ◽

Recent Laboratory

The increasing use of products containing peracetic acid for the disinfection of sewage and effluents has produced a demand for information about the activity of PAA against relevant microorganisms. Studies have therefore taken place to establish the comparative effects of peracetic acid and chlorine on both bacteria and viruses. Peracetic acid has previously been shown to be active against faecal indicator bacteria Recent laboratory studies have established that peracetic acid is also an effective agent against viruses typical of those found in sewage. This activity is maintained even in experimental systems containing high levels of organic matter such as yeast extract. In contrast, although sodium hypochlorite is an effective virucide in clean experimental systems, the presence of organic matter greatly increases the level of added available chlorine necessary to achieve a given level of viral inactivation.

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A Higher than Expected Incidence of Factor VIII Inhibitors in Multitransfused Haemophilia A Patients Treated with an Intermediate Purity Pasteurized Factor VIII Concentrate

Thrombosis and Haemostasis ◽

10.1055/s-0038-1651565 ◽

1993 ◽

Vol 69 (02) ◽

pp. 115-118 ◽

Cited By ~ 131

Author(s):

Kathelijne Peerlinck ◽

Jef Arnout ◽

Jean Guy Gilles ◽

Jean-Marie Saint-Remy ◽

Jos Vermylen

Keyword(s):

Factor Viii ◽

Randomized Trials ◽

Specific Factor ◽

Factor Viii Inhibitor ◽

Haemophilia A ◽

Viral Inactivation ◽

Gradual Decline ◽

Inhibitor Level ◽

Factor Viii Concentrates ◽

Viii Inhibitor

SummaryIn May 1990, 218 patients with haemophilia A regularly attending the Leuven Haemophilia Center were randomly assigned to a group receiving either of two newly introduced factor VIII concentrates: factor VIII-P, an intermediate purity pasteurized concentrate, or factor VIII-SD, a high purity concentrate treated with solvent-detergent for viral inactivation.Patients were followed from May 1990 until October 1991. Between August 1991 and October 1991 a clinically important factor VIII inhibitor was detected in five out of the 109 patients receiving factor VIII-P while none of the 109 patients receiving factor VIII-SD developed such antibodies. All patients acquiring an inhibitor had previously been clinically tolerant to transfused factor VIII with 200 to more than 1,000 days of exposure to factor VIII prior to May 1990. Patients with inhibitors were transfused daily with 30 U factor VIII-SD per kg body weight, which was associated with a gradual decline of the inhibitor level. In all patients the antibodies were relatively slow-acting and predominantly directed towards the light chain of factor VIII.This study demonstrates a higher than expected incidence of factor VIII inhibitors associated with the use of a specific factor VIII concentrate in multitransfused haemophilia A patients. It indicates the usefulness of evaluating newly introduced concentrates in prospective, randomized trials.

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Обеззараживание семян капусты от сосудистого бактериоза

Kartofel` i ovoshi ◽

10.25630/pav.2018.1.17457 ◽

2018 ◽

Author(s):

A.T. Orynbayev ◽

F.S. Dzhalilov

Keyword(s):

Peracetic Acid ◽

Biological Efficiency ◽

Black Rot ◽

Presowing Treatment

Приведены данные двухлетнего исследования по поиску эффективных препаратов для обеззараживания семян капусты от сосудистого бактериоза. Наилучший результат был получен при предпосевной обработке 0,15%-ной надуксусной кислотой. При этом биологическая эффективность составляла 94,1–97,6%, что значительно превышало соответствующий показатель в эталонном варианте – Фитолавин, ВРК, 0,2% (69,0–72,0%). Показано, что заблаговременная обработка семян НУК (за 550 суток до посева) не оказывала достоверного влияния на их лабораторную всхожесть.Presented data are the result of a two-year study aimed at identifying effective preparations for the disinfection of cabbage seeds from black rot. The best result was obtained by presowing treatment with 0.15% peracetic acid. In this case, the biological efficiency was 94.1–97.6%, which significantly exceeded the corresponding indicator in the reference variant – Phytolavin, VRK, 0.2% (69.0–72.0%). The study has not revealed any significant effect of advance treatment of seeds with peracetic acid (550 days before sowing) on their laboratory germination.

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Behaviour of Coli Phages in Oxidation Ponds

Water Science & Technology ◽

10.2166/wst.1985.0113 ◽

1985 ◽

Vol 17 (10) ◽

pp. 219-227 ◽

Cited By ~ 9

Author(s):

T. Omura ◽

H. K. Shin ◽

A. Ketratanakul

Keyword(s):

Laboratory Experiments ◽

Field Investigation ◽

Host Cells ◽

Coliform Bacteria ◽

Alkaline Ph ◽

Viral Inactivation ◽

Effects Of Temperature ◽

Oxidation Ponds ◽

Incubation Temperatures ◽

Inactivation Efficiency

Coliphages are among the most promising indicators of viral inactivation efficiency of wastewater treatment. Therefore, it is important to investigate the behaviour of coliphages in oxidation ponds from the viewpoint of predicting the inactivation of infectious viruses. In this study, numbers of coliphages were measured in oxidation ponds consisting of a series of facultative and maturation ponds. In parallel with this investigation, the effects of temperature and pH on the behaviour of coliphages were examined in the laboratory, employing three species of coliform bacteria as host cells. The field investigation showed that there was positive correlation between counts of coliphages and those of coliform bacteria, and that more than 99% of coliphages were inactivated. The inactivation efficiency of coliphages in the facultative pond was much higher than in the maturation pond. The results of the laboratory experiments indicated that at 30°C more than 99% of the coliform group were destroyed in 7 days of incubation and that coliphages counts increased from 105/100 ml to 107/100 ml with a lag time of 3 days. Greater reduction of the coliform count was obtained at higher incubation temperatures. It was observed that the coliphages possessed greater ability to attack coliform bacteria at acidic rather than alkaline pH.

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Viral inactivation by potassium ferrate

Water Science & Technology ◽

10.2166/wst.1995.0591 ◽

1995 ◽

Vol 31 (5-6) ◽

pp. 165-168 ◽

Cited By ~ 10

Author(s):

Futaba Kazama

Keyword(s):

Phosphate Buffer ◽

Potassium Ferrate ◽

Sodium Thiosulphate ◽

Viral Inactivation ◽

Complete Decomposition ◽

Kinetics Of ◽

Oxidative Intermediate

The kinetics of inactivation by potassium ferrate were studied using a bacteriophage, F-specific RNA-coliphage Qβ as a viral model. The inactivation appeared to be expressed by Hom's model in phosphate buffer at pH 6, 7, and 8. The rate of inactivation depended on pH; the lower pH, the faster inactivation observed. To consider the mechanism by which ferrate caused inactivation, the efficiency of inactivation was checked after ferrate decomposition in buffer. Effective inactivation following Hom's model was also observed after the complete decomposition of ferrate ion; however, the efficiency of that inactivation disappeared by the addition of sodium thiosulphate, suggesting that rather long-lived oxidative intermediate was generated by the decomposition of ferrate ion. The intermediate might take part in the inactivation.

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