Tissue-Specific Accumulation, Biotransformation, and Physiologically Based Toxicokinetic Modeling of Benzotriazole Ultraviolet Stabilizers in Zebrafish (Danio rerio)

2021 ◽  
Vol 55 (17) ◽  
pp. 11874-11884
Author(s):  
Shuying Zhang ◽  
Zhongyu Wang ◽  
Jingwen Chen ◽  
Qing Xie ◽  
Minghua Zhu ◽  
...  
Keyword(s):  
Danio Rerio ◽  
Tissue Specific ◽  
Physiologically Based ◽  
Specific Accumulation

Tissue-Specific Accumulation, Depuration, and Transformation of Triphenyl Phosphate (TPHP) in Adult Zebrafish (Danio rerio)

2016 ◽  
Vol 50 (24) ◽  
pp. 13555-13564 ◽  
Author(s):  
Guowei Wang ◽  
Zhongkun Du ◽  
Hanyan Chen ◽  
Yu Su ◽  
Shixiang Gao ◽  
...  
Keyword(s):  
Danio Rerio ◽  
Adult Zebrafish ◽  
Triphenyl Phosphate ◽  
Tissue Specific ◽  
Specific Accumulation

Tissue-Specific Accumulation, Elimination, and Toxicokinetics of Illicit Drugs in Adult Zebrafish (Danio rerio)

2021 ◽  
pp. 148153
Author(s):  
Xingxing Yin ◽  
Changsheng Guo ◽  
Yanghui Deng ◽  
Xiaowei Jin ◽  
Yanguo Teng ◽  
...  
Keyword(s):  
Danio Rerio ◽  
Illicit Drugs ◽  
Adult Zebrafish ◽  
Tissue Specific ◽  
Specific Accumulation

Tissue-specific accumulation of carotenoids in carrot roots

Planta ◽  
2006 ◽  
Vol 224 (5) ◽  
pp. 1028-1037 ◽  
Author(s):  
Malgorzata Baranska ◽  
Rafal Baranski ◽  
Hartwig Schulz ◽  
Thomas Nothnagel
Keyword(s):  
Tissue Specific ◽  
Specific Accumulation

scholarly journals Synaptic and epidermal accumulations of human acetylcholinesterase are encoded by alternative 3'-terminal exons.

1995 ◽  
Vol 15 (6) ◽  
pp. 2993-3002 ◽  
Author(s):  
S Seidman ◽  
M Sternfeld ◽  
R Ben Aziz-Aloya ◽  
R Timberg ◽  
D Kaufer-Nachum ◽  
...  
Keyword(s):  
Neuromuscular Junctions ◽  
Gene Transcript ◽  
Dna Encoding ◽  
Tissue Specific ◽  
Evolutionarily Conserved ◽  
Low Salt ◽  
Catalytically Active ◽  
Specific Accumulation ◽  
The Brain ◽  
Muscle Ache

Tissue-specific heterogeneity among mammalian acetylcholinesterases (AChE) has been associated with 3' alternative splicing of the primary AChE gene transcript. We have previously demonstrated that human AChE DNA encoding the brain and muscle AChE form and bearing the 3' exon E6 (ACHE-E6) induces accumulation of catalytically active AChE in myotomes and neuromuscular junctions (NMJs) of 2- and 3-day-old Xenopus embryos. Here, we explore the possibility that the 3'-terminal exons of two alternative human AChE cDNA constructs include evolutionarily conserved tissue-recognizable elements. To this end, DNAs encoding alternative human AChE mRNAs were microinjected into cleaving embryos of Xenopus laevis. In contrast to the myotomal expression demonstrated by ACHE-E6, DNA carrying intron 14 and alternative exon E5 (ACHE-I4/E5) promoted punctuated staining of epidermal cells and secretion of AChE into the external medium. Moreover, ACHE-E6-injected embryos displayed enhanced NMJ development, whereas ACHE-I4/E5-derived enzyme was conspicuously absent from muscles and NMJs and its expression in embryos had no apparent effect on NMJ development. In addition, cell-associated AChE from embryos injected with ACHE-I4/E5 DNA was biochemically distinct from that encoded by the muscle-expressible ACHE-E6, displaying higher electrophoretic mobility and greater solubility in low-salt buffer. These findings suggest that alternative 3'-terminal exons dictate tissue-specific accumulation and a particular biological role(s) of AChE, associate the 3' exon E6 with NMJ development, and indicate the existence of a putative secretory AChE form derived from the alternative I4/E5 AChE mRNA.

Transfer and tissue-specific accumulation of components in embryos of Caenorhabditis elegans and dolichura: in vivo analysis with a low-cost signal

Development ◽  
1992 ◽  
Vol 114 (2) ◽  
pp. 317-330 ◽  
Author(s):  
O. Bossinger ◽  
E. Schierenberg
Keyword(s):  
Caenorhabditis Elegans ◽  
Low Cost ◽  
Free Living ◽  
Tissue Specific ◽  
C Elegans ◽  
Specific Accumulation ◽  
In Vivo Analysis

The pattern of autofluorescence in the two free-living namatodes Rhabditis dolichura and Caenorhabditis compared. In C. elegans, during later embryogenesis cells develop a typical bluish autofluorescence as illumination, while in Rh. dolichura a strong already present in the unfertilized egg. Using a new,

Assessing hexavalent chromium tissue-specific accumulation patterns and induced physiological responses to probe chromium toxicity in Coturnix japonica quail

Chemosphere ◽  
2021 ◽  
Vol 266 ◽  
pp. 129005
Author(s):  
Damir Suljević ◽  
Jasmina Sulejmanović ◽  
Muhamed Fočak ◽  
Erna Halilović ◽  
Džemila Pupalović ◽  
...  
Keyword(s):  
Hexavalent Chromium ◽  
Physiological Responses ◽  
Coturnix Japonica ◽  
Chromium Toxicity ◽  
Tissue Specific ◽  
Specific Accumulation

scholarly journals Time-Dependent and Tissue-Specific Accumulation of mtDNA and Respiratory Chain Defects in Chronic Doxorubicin Cardiomyopathy

Circulation ◽  
2003 ◽  
Vol 108 (19) ◽  
pp. 2423-2429 ◽  
Author(s):  
Dirk Lebrecht ◽  
Bernhard Setzer ◽  
Uwe-Peter Ketelsen ◽  
Jörg Haberstroh ◽  
Ulrich A. Walker
Keyword(s):  
Respiratory Chain ◽  
Time Dependent ◽  
Tissue Specific ◽  
Specific Accumulation ◽  
Chain Defects ◽  
Respiratory Chain Defects ◽  
Doxorubicin Cardiomyopathy

Bean leaf abscission: Tissue-specific accumulation of a cellulase mRNA

Planta ◽  
1991 ◽  
Vol 186 (1) ◽  
Author(s):  
MarkL. Tucker ◽  
SusanL. Baird ◽  
Roy Sexton
Keyword(s):  
Leaf Abscission ◽  
Tissue Specific ◽  
Specific Accumulation

scholarly journals Hierarchical subfunctionalization of fabp1a, fabp1b and fabp10 tissue-specific expression may account for retention of these duplicated genes in the zebrafish (Danio rerio) genome

FEBS Journal ◽  
2006 ◽  
Vol 273 (14) ◽  
pp. 3216-3229 ◽  
Author(s):  
Mukesh K. Sharma ◽  
Rong-Zong Liu ◽  
Christine Thisse ◽  
Bernard Thisse ◽  
Eileen M. Denovan-Wright ◽  
...  
Keyword(s):  
Danio Rerio ◽  
Duplicated Genes ◽  
Specific Expression ◽  
Tissue Specific ◽  
Tissue Specific Expression
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