A Population-Based Cohort Study of Respiratory Disease and Long-Term Exposure to Iron and Copper in Fine Particulate Air Pollution and Their Combined Impact on Reactive Oxygen Species Generation in Human Lungs

2021 ◽  
Vol 55 (6) ◽  
pp. 3807-3818
Author(s):  
Zilong Zhang ◽  
Scott Weichenthal ◽  
Jeffrey C. Kwong ◽  
Richard T. Burnett ◽  
Marianne Hatzopoulou ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Air Pollution ◽  
Reactive Oxygen Species Generation ◽  
Population Based ◽  
Oxygen Species ◽  
Particulate Air Pollution ◽  
Fine Particulate ◽  
Human Lungs ◽  
Combined Impact

scholarly journals Long-term exposure to iron and copper in fine particulate air pollution and their combined impact on reactive oxygen species concentration in lung fluid: a population-based cohort study of cardiovascular disease incidence and mortality in Toronto, Canada

2020 ◽  
Author(s):  
Zilong Zhang ◽  
Scott Weichenthal ◽  
Jeffrey C Kwong ◽  
Richard T Burnett ◽  
Marianne Hatzopoulou ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Cardiovascular Disease ◽  
Regression Models ◽  
Population Based ◽  
Sensitivity Analyses ◽  
Oxygen Species ◽  
Lung Fluid ◽  
Fine Particulate ◽  
Combined Impact

Abstract Background Exposure to fine particulate (PM2.5) air pollution is associated with increased cardiovascular disease (CVD), but less is known about its specific components, such as metals originating from non-tailpipe emissions. We investigated the associations of long-term exposure to metal components [iron (Fe) and copper (Cu)] in PM2.5 with CVD incidence. Methods We conducted a population-based cohort study in Toronto, Canada. Exposures to Fe and Cu in PM2.5 and their combined impact on the concentration of reactive oxygen species (ROS) in lung fluid were estimated using land use regression models. Incidence of acute myocardial infarction (AMI), congestive heart failure (CHF) and CVD death was ascertained using health administrative datasets. We used mixed-effects Cox regression models to examine the associations between the exposures and health outcomes. A series of sensitivity analyses were conducted, including indirect adjustment for individual-level cardiovascular risk factors (e.g. smoking), and adjustment for PM2.5 and nitrogen dioxide (NO2). Results In single-pollutant models, we found positive associations between the three exposures and all three outcomes, with the strongest associations detected for the estimated ROS. The associations of AMI and CHF were sensitive to indirect adjustment, but remained robust for CVD death in all sensitivity analyses. In multi-pollutant models, the associations of the three exposures generally remained unaltered. Interestingly, adjustment for ROS did not substantially change the associations between PM2.5 and CVD, but attenuated the associations of NO2. Conclusions Long-term exposure to Fe and Cu in PM2.5 and their combined impact on ROS were consistently associated with increased CVD death.

scholarly journals Air pollution and human health: Long-term exposure to fine particulate air pollution associated with natural-cause mortality

2014 ◽  
Vol 24 (1) ◽  
pp. 6
Author(s):  
R. Beelen ◽  
O. Raaschou-Nielsen ◽  
M. Stafoggia ◽  
Z.J. Andersen ◽  
G. Weinmayr ◽  
...  
Keyword(s):  
Air Pollution ◽  
Human Health ◽  
Particulate Air Pollution ◽  
Fine Particulate

scholarly journals STROBE-Long-Term Exposure to Ambient Fine Particulate Air Pollution and Hospitalization Due to Peptic Ulcers

Medicine ◽  
2016 ◽  
Vol 95 (18) ◽  
pp. e3543 ◽  
Author(s):  
Chit-Ming Wong ◽  
Hilda Tsang ◽  
Hak-Kan Lai ◽  
Thuan-Quoc Thach ◽  
G. Neil Thomas ◽  
...  
Keyword(s):  
Air Pollution ◽  
Peptic Ulcers ◽  
Particulate Air Pollution ◽  
Fine Particulate

scholarly journals Long-Term Exposure to Constituents of Fine Particulate Air Pollution and Mortality: Results from the California Teachers Study

2010 ◽  
Vol 118 (3) ◽  
pp. 363-369 ◽  
Author(s):  
Bart Ostro ◽  
Michael Lipsett ◽  
Peggy Reynolds ◽  
Debbie Goldberg ◽  
Andrew Hertz ◽  
...  
Keyword(s):  
Air Pollution ◽  
Particulate Air Pollution ◽  
Fine Particulate
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