Toxicity Testing of Effluent-Dominated Stream Using Predictive Molecular-Level Toxicity Signatures Based on High-Resolution Mass Spectrometry: A Case Study of the Lubbock Canyon Lake System

2021 ◽  
Author(s):  
Naveen Kumar ◽  
Haoqi Nina Zhao ◽  
Olushola Awoyemi ◽  
Edward P. Kolodziej ◽  
Jordan Crago
Keyword(s):  
Mass Spectrometry ◽  
High Resolution ◽  
Molecular Level ◽  
High Resolution Mass Spectrometry ◽  
Toxicity Testing ◽  
Lake System ◽  
High Resolution Mass ◽  
Resolution Mass

Molecular-level heavy petroleum hydrotreating modeling and comparison with high-resolution mass spectrometry

Fuel ◽  
2021 ◽  
Vol 297 ◽  
pp. 120792
Author(s):  
Dong Guan ◽  
Zhengyu Chen ◽  
Xiu Chen ◽  
Ying Zhang ◽  
Qiuyan Qi ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
High Resolution ◽  
Molecular Level ◽  
High Resolution Mass Spectrometry ◽  
Heavy Petroleum ◽  
High Resolution Mass ◽  
Resolution Mass

scholarly journals Doping Control Using High and Ultra-High Resolution Mass Spectrometry Based Non-Targeted Metabolomics-A Case Study of Salbutamol and Budesonide Abuse

PLoS ONE ◽  
2013 ◽  
Vol 8 (9) ◽  
pp. e74584 ◽  
Author(s):  
Agneta Kiss ◽  
Marianna Lucio ◽  
Aurélie Fildier ◽  
Corinne Buisson ◽  
Philippe Schmitt-Kopplin ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
High Resolution ◽  
High Resolution Mass Spectrometry ◽  
Doping Control ◽  
Targeted Metabolomics ◽  
High Resolution Mass ◽  
Resolution Mass

Probing the Mechanism of Action of Potential Anticancer Agents at a Molecular Level Using Electrospray Ionisation Fourier Transform Ion Cyclotron Resonance Mass Spectrometry

2009 ◽  
Vol 15 (5) ◽  
pp. 661-672 ◽  
Author(s):  
Lutz F. Tietze ◽  
Birgit Krewer ◽  
Holm Frauendorf
Keyword(s):  
Mass Spectrometry ◽  
High Resolution ◽  
Anticancer Agents ◽  
Mode Of Action ◽  
Molecular Level ◽  
High Resolution Mass Spectrometry ◽  
New Drugs ◽  
Duplex Dna ◽  
High Resolution Mass ◽  
Resolution Mass

Treating cancer without harming healthy tissue is an important goal in modern medicine. Our research group has developed a series of novel, relatively non-toxic glycosidic prodrugs that are activated to give the corresponding highly cytotoxic drugs selectively in the tumour tissue. Our first investigations have shown a high duplex DNA alkylation efficiency of the drugs, whereas the prodrugs showed almost no tendency for alkylation of duplex DNA. Herein we report on novel investigations of the mode of action of the anti-cancer drugs on a molecular level. Using high-resolution mass spectrometry, we determined the reactivity of these drugs as well as of other drugs of similar structure against different nucleophiles such as RNA and the tripeptide glutathione. In addition, the new drugs were also tested for their interaction with duplex DNA. All compounds show a high reactivity against duplex DNA, whereas the alkylation efficiency regarding RNA and glutathione is only poor. Furthermore, the alkylation of duplex DNA correlates qualitatively but not quantitatively with the cytotoxicity of the drugs. Consequently, other factors besides the alkylation efficiency such as the stability of the drugs seem to influence their biological activity. Altogether the results show that high-resolution mass spectrometry constitutes a powerful method for studying the mode of action of drugs on a molecular level.

Molecular-Level Characterization of Refinery Streams by High-Resolution Mass Spectrometry

2015 ◽  
Vol 29 (5) ◽  
pp. 2940-2950 ◽  
Author(s):  
Vatsala Sugumaran ◽  
Hillol Biswas ◽  
Anil Yadav ◽  
Jayaraj Christopher ◽  
Vivekanand Kagdiyal ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
High Resolution ◽  
Molecular Level ◽  
High Resolution Mass Spectrometry ◽  
High Resolution Mass ◽  
Resolution Mass
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