scholarly journals Correction to Degradation and Deactivation of Bacterial Antibiotic Resistance Genes during Exposure to Free Chlorine, Monochloramine, Chlorine Dioxide, Ozone, Ultraviolet Light, and Hydroxyl Radical

2020 ◽  
Vol 54 (17) ◽  
pp. 10975-10975
Author(s):  
Huan He ◽  
Peiran Zhou ◽  
Kyle K. Shimabuku ◽  
Xuzhi Fang ◽  
Shu Li ◽  
...  
Keyword(s):  
Antibiotic Resistance ◽  
Hydroxyl Radical ◽  
Ultraviolet Light ◽  
Resistance Genes ◽  
Chlorine Dioxide ◽  
Antibiotic Resistance Genes ◽  
Free Chlorine ◽  
Bacterial Antibiotic Resistance

A Review of Bacterial Antibiotic Resistance Genes and Their Removal Strategies from Wastewater

2021 ◽  
Author(s):  
Zainura Zainon Noor ◽  
Zainab Rabiu ◽  
Mohd. Helmi Mohd. Sani ◽  
Abdul Fatah A. Samad ◽  
Mohd. Farizal Ahmad Kamaroddin ◽  
...  
Keyword(s):  
Antibiotic Resistance ◽  
Resistance Genes ◽  
Antibiotic Resistance Genes ◽  
Bacterial Antibiotic Resistance

scholarly journals Chlorine disinfection facilitates natural transformation through ROS-mediated oxidative stress

2021 ◽  
Author(s):  
Shuai Zhang ◽  
Yue Wang ◽  
Ji Lu ◽  
Zhigang Yu ◽  
Hailiang Song ◽  
...  
Keyword(s):  
Antibiotic Resistance ◽  
Resistance Genes ◽  
Natural Transformation ◽  
Membrane Damage ◽  
Antibiotic Resistance Genes ◽  
Free Chlorine ◽  
Water Disinfection ◽  
Resistant Bacteria ◽  
Residual Chlorine ◽  
Acinetobacter Baylyi

AbstractThe bacterial infection that involves antimicrobial resistance is a rising global threat to public health. Chlorine-based water disinfection processes can inactivate antibiotic resistant bacteria. However, at the same time, these processes may cause the release of antibiotic resistance genes into the water as free DNA, and consequently increase the risk to disseminate antibiotic resistance via natural transformation. Presently, little is known about the contribution of residual chlorine affecting the transformation of extracellular antibiotic resistance genes (ARGs). This study investigates whether chloramine and free chlorine promote the transformation of ARGs and how this may occur. We reveal that both chloramine and free chlorine, at practically relevant concentrations, significantly stimulated the transformation of plasmid-encoded ARGs by the recipient Acinetobacter baylyi ADP1, by up to a 10-fold increase. The underlying mechanisms underpinning the increased transformations were revealed. Disinfectant exposure induced a series of cell responses, including increased levels of reactive oxygen species (ROS), bacterial membrane damage, ROS-mediated DNA damage, and increased stress response. These effects thus culminated in the enhanced transformation of ARGs. This promoted transformation was observed when exposing disinfectant-pretreated A. baylyi to free plasmid. In contrast, after pretreating free plasmid with disinfectants, the transformation of ARGs decreased due to the damage of plasmid integrity. These findings provide important insight on the roles of disinfectants affecting the horizontal transfer of ARGs, which could be crucial in the management of antibiotic resistance in our water systems.

Sign in / Sign up

Export Citation Format

Share Document