Surface Modulation and Chromium Complexation: All-in-One Solution for the Cr(VI) Sequestration with Bifunctional Molecules

2020 ◽  
Vol 54 (13) ◽  
pp. 8373-8379 ◽  
Author(s):  
Xuyan Gao ◽  
Yue Zhang ◽  
Fengmin Li ◽  
Boyang Tian ◽  
Xiao Wang ◽  
...  
Keyword(s):  
Bifunctional Molecules ◽  
Surface Modulation ◽  
Chromium Complexation

PHOTACs Enable Optical Control of Protein Degradation

2019 ◽  
Author(s):  
Martin Reynders ◽  
Bryan Matsuura ◽  
Marleen Bérouti ◽  
Daniele Simoneschi ◽  
Antonio Marzio ◽  
...  
Keyword(s):  
Protein Degradation ◽  
E3 Ligase ◽  
Optical Control ◽  
Cellular Proteins ◽  
Bifunctional Molecules ◽  
Protein Levels ◽  
Lead Compounds ◽  
Subsequent Degradation ◽  
Temporal And Spatial ◽  
Precision Therapeutics

<p><i>PROTACs (proteolysis targeting chimeras) are bifunctional molecules that tag proteins for ubiquitylation by an E3 ligase complex and subsequent degradation by the proteasome. They have emerged as powerful tools to control the levels of specific cellular proteins and are on the verge of being clinically used. We now introduce photoswitchable PROTACs that can be activated with the temporal and spatial precision that light provides. These trifunctional molecules, which we named PHOTACs, consist of a ligand for an E3 ligase, a photoswitch, and a ligand for a protein of interest. We demonstrate this concept by using PHOTACs that target either BET family proteins (BRD2,3,4) or FKBP12. Our lead compounds display little or no activity in the dark but can be reversibly activated to varying degrees with different wavelengths of light. Our modular and generalizable approach provides a method for the optical control of protein levels with photopharmacology and could lead to new types of precision therapeutics that avoid undesired systemic toxicity.</i><b></b></p>

Engineering Amino-mediated Copper Nanoclusters with Dual Emission and Assembly-to-monodispersion Switching by pH-Triggered Surface Modulation

2021 ◽  
Author(s):  
Bingyan Han ◽  
Qifang Yan ◽  
Ze Xin ◽  
Qingdong Liu ◽  
Dan Li ◽  
...  
Keyword(s):  
Copper Nanoclusters ◽  
Dual Emission ◽  
Surface Modulation

Herein we report L-cysteine (Cys)-mediated copper nanoclusters (CuNCs) with assembly-to-monodispersion switching by pH-triggered surface modulation. Aggregated red emissive (R)-CuNCs@Cys at pH=3 turn to monodispersed blue emissive (B)-CuNCs@Cys at pH=10, which...

Synergetic surface modulation of ZnO/Pt@ZIF-8 hybrid nanorods for enhanced photocatalytic CO2 valorization

2021 ◽  
Vol 287 ◽  
pp. 119934
Author(s):  
Xiao Li ◽  
Wanmei He ◽  
Chuanhao Li ◽  
Bo Song ◽  
Shengwei Liu
Keyword(s):  
Surface Modulation ◽  
Co2 Valorization

Effective and reversible DNA condensation induced by bifunctional molecules containing macrocyclic polyamines and naphthyl moieties

2012 ◽  
Vol 20 (2) ◽  
pp. 801-808 ◽  
Author(s):  
Hao Yan ◽  
Zhi-Fen Li ◽  
Zhi-Fo Guo ◽  
Zhong-Lin Lu ◽  
Feng Wang ◽  
...  
Keyword(s):  
Dna Condensation ◽  
Bifunctional Molecules ◽  
Macrocyclic Polyamines

A Dual-response Regenerable Luminescent 2D-MOF for Nitroaromatic Sensing via Target-modulation of Active Interaction Sites

2021 ◽  
Author(s):  
Farzaneh Afshariazar ◽  
Ali Morsali ◽  
Maolin Hu
Keyword(s):  
Nitroaromatic Compounds ◽  
Sensitive Detection ◽  
Environmental Concerns ◽  
Interaction Sites ◽  
Dual Response ◽  
Surface Modulation ◽  
Active Interaction

Sensitive detection of nitroaromatic compounds is of urgent need due to the serious environmental concerns. Surface modulation is a remarkable approach to alter the accessibility of the active interaction sites...

Transforming ligands into transcriptional regulators: building blocks for bifunctional molecules

2011 ◽  
Vol 40 (8) ◽  
pp. 4286 ◽  
Author(s):  
Jonas W. Højfeldt ◽  
Aaron R. Van Dyke ◽  
Anna K. Mapp
Keyword(s):  
Transcriptional Regulators ◽  
Building Blocks ◽  
Bifunctional Molecules

scholarly journals Sonochemical Reaction of Bifunctional Molecules on Silicon (111) Hydride Surface

Molecules ◽  
2021 ◽  
Vol 26 (20) ◽  
pp. 6166
Author(s):  
Serge Ismael Zida ◽  
Yue-Der Lin ◽  
Yit Lung Khung
Keyword(s):  
Photoelectron Spectroscopy ◽  
Lone Pair ◽  
Thermal Reaction ◽  
Silicon Hydride ◽  
Force Microscopy ◽  
Bifunctional Molecules ◽  
Bond Breakage ◽  
Sonochemical Reaction ◽  
Grafting From ◽  
P Type

While the sonochemical grafting of molecules on silicon hydride surface to form stable Si–C bond via hydrosilylation has been previously described, the susceptibility towards nucleophilic functional groups during the sonochemical reaction process remains unclear. In this work, a competitive study between a well-established thermal reaction and sonochemical reaction of nucleophilic molecules (cyclopropylamine and 3-Butyn-1-ol) was performed on p-type silicon hydride (111) surfaces. The nature of surface grafting from these reactions was examined through contact angle measurements, X-ray photoelectron spectroscopy (XPS) and atomic force microscopy (AFM). Cyclopropylamine, being a sensitive radical clock, did not experience any ring-opening events. This suggested that either the Si–H may not have undergone homolysis as reported previously under sonochemical reaction or that the interaction to the surface hydride via a lone-pair electron coordination bond was reversible during the process. On the other hand, silicon back-bond breakage and subsequent surface roughening were observed for 3-Butyn-1-ol at high-temperature grafting (≈150 °C). Interestingly, the sonochemical reaction did not produce appreciable topographical changes to surfaces at the nano scale and the further XPS analysis may suggest Si–C formation. This indicated that while a sonochemical reaction may be indifferent towards nucleophilic groups, the surface was more reactive towards unsaturated carbons. To the best of the author’s knowledge, this is the first attempt at elucidating the underlying reactivity mechanisms of nucleophilic groups and unsaturated carbon bonds during sonochemical reaction of silicon hydride surfaces.

Synthesis and structural characteristics of lithocholate triads: steroid-type channels occupied by spacer fragments

2008 ◽  
Vol 64 (3) ◽  
pp. 383-392 ◽  
Author(s):  
Urszula Rychlewska ◽  
Beata Warżajtis ◽  
Roman Joachimiak ◽  
Zdzisław Paryzek
Keyword(s):  
Inclusion Complexes ◽  
Terephthalic Acid ◽  
Lithocholic Acid ◽  
Structural Characteristics ◽  
Guest Molecules ◽  
Face To Face ◽  
Bifunctional Molecules ◽  
Hydrogen Bond Interactions ◽  
Crystal Density ◽  
Efficient Packing

Reported in this paper are the syntheses and X-ray investigations of C 2 symmetrical molecular A—B—A triads consisting of two steroid units (lithocholic acid or its methyl ester) joined together by linkers derived from bifunctional molecules such as terephthalic acid or N,N′-dicarboxypiperazine. Unlike their monomeric analogues, some of these compounds form inclusion complexes. All steroidal triads form crystals that are highly pseudo-centrosymmetric, in which the constituting molecules are held together either exclusively by van der Waals forces or form lattice inclusion complexes, with guest molecules hydrogen bonded to the host. The presence of carboxyl groups promotes the inclusion of pyridine molecules and the formation of the well known carboxylic acid...pyridine hydrogen bonds. Combined with pairwise face-to-face π-stacking between pyridine rings, these hydrogen-bond interactions lead to the formation of extended supramolecular tapes, analogous to polymers. The co-crystals of pyridine and a lithocholic acid triad undergo a symmetry-lowering phase transition from a P1 cell with Z = 1 to a P1 cell with Z = 2. The two structures are virtually the same, the two independent molecules in the larger cell being related by pseudo-translation. Changes in the type of spacer between two methyl lithocholate units from planar aromatic (terephthalic acid) to highly puckered aliphatic six-membered ring (N,N′-dicarboxypiperazine) bring about inclusion properties and changes in side-chain conformation in a crystal. Although the efficient packing of these highly elongated molecules is hindered, as indicated by low values of crystal density, ranging from 1.16 to 1.19 g cm−3, several very short C...O and H...H contacts are present in the crystals.

Sign in / Sign up

Export Citation Format

Share Document