scholarly journals Promotion of Mefenamic Acid Nucleation by a Surfactant Additive, Docusate Sodium

2018 ◽  
Vol 19 (2) ◽  
pp. 591-603 ◽  
Author(s):  
Katalin Bodnár ◽  
Sarah P. Hudson ◽  
Åke C. Rasmuson
Keyword(s):  
Mefenamic Acid ◽  
Surfactant Additive ◽  
Docusate Sodium

HŒMOLYTIC REACTION TO MEFENAMIC ACID

The Lancet ◽  
1971 ◽  
Vol 298 (7224) ◽  
pp. 607-608 ◽  
Author(s):  
C Kennedy
Keyword(s):  
Mefenamic Acid

Multidose Analgesic Study of Two Mefenamic Acid Formulations in a Postsurgical Dental Pain Model

Analgesia ◽  
1994 ◽  
Vol 1 (1) ◽  
pp. 65-71 ◽  
Author(s):  
Stephen A. Cooper ◽  
Elliot V. Hersh ◽  
Norman J. Betts ◽  
David Wedell ◽  
Peter Quinn ◽  
...  
Keyword(s):  
Mefenamic Acid ◽  
Dental Pain ◽  
Pain Model

scholarly journals Investigating the Feasibility of Mefenamic Acid Nanosuspension for Pediatric Delivery: Preparation, Characterization, and Role of Excipients

Processes ◽  
2021 ◽  
Vol 9 (4) ◽  
pp. 574
Author(s):  
Nikhat Perween ◽  
Sultan Alshehri ◽  
T. S. Easwari ◽  
Vivek Verma ◽  
Md. Faiyazuddin ◽  
...  
Keyword(s):  
Particle Size ◽  
Mefenamic Acid ◽  
Hydroxypropyl Methylcellulose ◽  
Sodium Dodecyl ◽  
Aqueous Solubility ◽  
Oral Route ◽  
Precipitation Method ◽  
Antisolvent Precipitation

Molecules with poor aqueous solubility are difficult to formulate using conventional approaches and are associated with many formulation delivery issues. To overcome these obstacles, nanosuspension technology can be one of the promising approaches. Hence, in this study, the feasibility of mefenamic acid (MA) oral nanosuspension was investigated for pediatric delivery by studying the role of excipients and optimizing the techniques. Nanosuspensions of MA were prepared by adopting an antisolvent precipitation method, followed by ultrasonication with varying concentrations of polymers, surfactants, and microfluidics. The prepared nanosuspensions were evaluated for particle size, morphology, and rheological measures. Hydroxypropyl methylcellulose (HPMC) with varying concentrations and different stabilizers including Tween® 80 and sodium dodecyl sulfate (SLS) were used to restrain the particle size growth of the developed nanosuspension. The optimized nanosuspension formula was stable for more than 3 weeks and showed a reduced particle size of 510 nm with a polydispersity index of 0.329. It was observed that the type and ratio of polymer stabilizers were responsive on the particle contour and dimension and stability. We have developed a biologically compatible oral nanoformulation for a first-in-class drug beautifully designed for pediatric delivery that will be progressed toward further in vivo enabling studies. Finally, the nanosuspension could be considered a promising carrier for pediatric delivery of MA through the oral route with enhanced biological impact.

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