Hydrogel Composite Membranes Incorporating Iron Oxide Nanoparticles as Topographical Designers for Controlled Heteronucleation of Proteins

2018 ◽  
Vol 18 (6) ◽  
pp. 3317-3327 ◽  
Author(s):  
Shabnam Majidi Salehi ◽  
Ana C. Manjua ◽  
Benny D. Belviso ◽  
Carla A. M. Portugal ◽  
Isabel M. Coelhoso ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Composite Membranes ◽  
Oxide Nanoparticles ◽  
Hydrogel Composite

Polyethylene glycol and iron oxide nanoparticles blended polyethersulfone ultrafiltration membrane for enhanced performance in dye removal studies

e-Polymers ◽  
2015 ◽  
Vol 15 (3) ◽  
pp. 151-159 ◽  
Author(s):  
Rambabu Krishnamoorthy ◽  
Velu Sagadevan
Keyword(s):  
Thermal Stability ◽  
Polyethylene Glycol ◽  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Pure Water ◽  
Composite Membranes ◽  
Process Time ◽  
Oxide Nanoparticles ◽  
Phase Inversion Technique ◽  
Pes Membrane

AbstractUltrafiltration (UF) is one of the most widely used membrane technologies for the effective separation of macromolecules in feed solutions. However, despite good separation efficiency, the UF membranes made up of pure polymers suffer to a greater extent because of low flux problem, which affects the process time and load. To handle this limitation, the base polymer is blended with a suitable additive to modify the structural and surface morphology of the membrane to provide better fluxes. In this current study, a series of polyethersulfone (PES) UF asymmetric membranes blended with polyethylene glycol and iron oxide nanoparticles was prepared using the phase inversion technique. Prepared membranes were analyzed for their morphology, thermal stability, and membrane characterization. Morphology studies using scanning electron microscopy and atomic force microscopy confirmed the increase in the number of pores, pore size in support layer, and surface roughness in the blended membranes, ensuring the chances of enhanced flux. Surface hydrophilicity was increased with the increase in the iron oxide concentration in the composite membranes. Thermal analysis studies showed the better thermal stability of the blended membranes. Pure water flux of the prepared composite membranes was improved to a maximum of four times in comparison with pure PES membrane. Dye rejection studies clearly showed that the blended membranes almost had the same rejection as that of pure PES membrane. Thus, the prepared PES composite UF membrane is a promising candidate for the treatment of dye-polluted wastewater, ensuring high fluxes and effective rejection.

TARGETING CYCLIN B1 WITH ANTISENSE OLIGONUCLETOTIDES- COATED SUPERPARAMAGNETIC IRON OXIDE NANOPARTICLES

2018 ◽  
Vol 6 (10) ◽  
Author(s):  
Hosam Zaghloul ◽  
Doaa A. Shahin ◽  
Ibrahim El- Dosoky ◽  
Mahmoud E. El-awady ◽  
Fardous F. El-Senduny ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Cellular Uptake ◽  
Superparamagnetic Iron Oxide ◽  
Cyclin B1 ◽  
Superparamagnetic Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Mcf7 Cells ◽  
M Phase ◽  
The Impact

Antisense oligonucleotides (ASO) represent an attractive trend as specific targeting molecules but sustain poor cellular uptake meanwhile superparamagnetic iron oxide nanoparticles (SPIONs) offer stability of ASO and improved cellular uptake. In the present work we aimed to functionalize SPIONs with ASO targeting the mRNA of Cyclin B1 which represents a potential cancer target and to explore its anticancer activity. For that purpose, four different SPIONs-ASO conjugates, S-M (1–4), were designated depending on the sequence of ASO and constructed by crosslinking carboxylated SPIONs to amino labeled ASO. The impact of S-M (1–4) on the level of Cyclin B1, cell cycle, ROS and viability of the cells were assessed by flowcytometry. The results showed that S-M3 and S-M4 reduced the level of Cyclin B1 by 35 and 36%, respectively. As a consequence to downregulation of Cyclin B1, MCF7 cells were shown to be arrested at G2/M phase (60.7%). S-M (1–4) led to the induction of ROS formation in comparison to the untreated control cells. Furthermore, S-M (1–4) resulted in an increase in dead cells compared to the untreated cells and SPIONs-treated cells. In conclusion, targeting Cyclin B1 with ASO-coated SPIONs may represent a specific biocompatible anticancer strategy.

Ferrozine Assay for Simple and Cheap Iron Analysis of Silica-Coated Iron Oxide Nanoparticles

2018 ◽  
Author(s):  
Hattie Ring ◽  
Zhe Gao ◽  
Nathan D. Klein ◽  
Michael Garwood ◽  
John C. Bischof ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Hydrofluoric Acid ◽  
Inductively Coupled Plasma ◽  
Silica Shell ◽  
Oxide Nanoparticles ◽  
Inductively Coupled ◽  
Digestion Process ◽  
Plasma Methods ◽  
Iron Analysis

The Ferrozinen assay is applied as an accurate and rapid method to quantify the iron content of iron oxide nanoparticles (IONPs) and can be used in biological matrices. The addition of ascorbic aqcid accelerates the digestion process and can penetrate an IONP core within a mesoporous and solid silica shell. This new digestion protocol avoids the need for hydrofluoric acid to digest the surrounding silica shell and provides and accessible alternative to inductively coupled plasma methods. With the updated digestion protocol, the quantitative range of the Ferrozine assay is 1 - 14 ppm. <br>

Ferrozine Assay for Simple and Cheap Iron Analysis of Silica-Coated Iron Oxide Nanoparticles

2018 ◽  
Author(s):  
Hattie Ring ◽  
Zhe Gao ◽  
Nathan D. Klein ◽  
Michael Garwood ◽  
John C. Bischof ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Hydrofluoric Acid ◽  
Inductively Coupled Plasma ◽  
Silica Shell ◽  
Oxide Nanoparticles ◽  
Inductively Coupled ◽  
Digestion Process ◽  
Plasma Methods ◽  
Iron Analysis

The Ferrozinen assay is applied as an accurate and rapid method to quantify the iron content of iron oxide nanoparticles (IONPs) and can be used in biological matrices. The addition of ascorbic aqcid accelerates the digestion process and can penetrate an IONP core within a mesoporous and solid silica shell. This new digestion protocol avoids the need for hydrofluoric acid to digest the surrounding silica shell and provides and accessible alternative to inductively coupled plasma methods. With the updated digestion protocol, the quantitative range of the Ferrozine assay is 1 - 14 ppm. <br>

EB PVD synthesis of iron oxide nanoparticles and their biological activity

2020 ◽  
Vol 2020 (3) ◽  
pp. 54-61
Author(s):  
S.E. Litvin ◽  
◽  
Yu.A. Kurapov ◽  
E.M. Vazhnichaya ◽  
Ya.A. Stel’makh ◽  
...  
Keyword(s):  
Biological Activity ◽  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles

Iron Oxide Nanoparticles: An Insight into their Biomedical Applications

2015 ◽  
Vol 22 (15) ◽  
pp. 1808-1828 ◽  
Author(s):  
Diana Couto ◽  
Marisa Freitas ◽  
Felix Carvalho ◽  
Eduarda Fernandes
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Biomedical Applications ◽  
Oxide Nanoparticles ◽  
Insight Into
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