Polymorphism in Pharmaceutical Drugs by Supercritical CO2 Processing: Clarifying the Role of the Antisolvent Effect and Atomization Enhancement

2016 ◽  
Vol 16 (11) ◽  
pp. 6222-6229 ◽  
Author(s):  
Miguel A. Rodrigues ◽  
João M. Tiago ◽  
Andreia Duarte ◽  
Vítor Geraldes ◽  
Henrique A. Matos ◽  
...  
Keyword(s):  
Supercritical Co2 ◽  
Pharmaceutical Drugs

scholarly journals The Role of Src Kinase in Macrophage-Mediated Inflammatory Responses

2012 ◽  
Vol 2012 ◽  
pp. 1-18 ◽  
Author(s):  
Se Eun Byeon ◽  
Young-Su Yi ◽  
Jueun Oh ◽  
Byong Chul Yoo ◽  
Sungyoul Hong ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Immune Responses ◽  
Inflammatory Responses ◽  
Inflammatory Diseases ◽  
Src Kinase ◽  
Multiple Roles ◽  
Cellular Migration ◽  
Pharmaceutical Drugs ◽  
Tyrosine Protein Kinase

Src kinase (Src) is a tyrosine protein kinase that regulates cellular metabolism, survival, and proliferation. Many studies have shown that Src plays multiple roles in macrophage-mediated innate immunity, such as phagocytosis, the production of inflammatory cytokines/mediators, and the induction of cellular migration, which strongly implies that Src plays a pivotal role in the functional activation of macrophages. Macrophages are involved in a variety of immune responses and in inflammatory diseases including rheumatoid arthritis, atherosclerosis, diabetes, obesity, cancer, and osteoporosis. Previous studies have suggested roles for Src in macrophage-mediated inflammatory responses; however, recently, new functions for Src have been reported, implying that Src functions in macrophage-mediated inflammatory responses that have not been described. In this paper, we discuss recent studies regarding a number of these newly defined functions of Src in macrophage-mediated inflammatory responses. Moreover, we discuss the feasibility of Src as a target for the development of new pharmaceutical drugs to treat macrophage-mediated inflammatory diseases. We provide insights into recent reports regarding new functions for Src that are related to macrophage-related inflammatory responses and the development of novel Src inhibitors with strong immunosuppressive and anti-inflammatory properties, which could be applied to various macrophage-mediated inflammatory diseases.

scholarly journals From Nursery to Nursing Home: Emerging Concepts in Clostridioides difficile Pathogenesis

2020 ◽  
Vol 88 (7) ◽  
Author(s):  
Alexander B. Smith ◽  
Joshua Soto Ocana ◽  
Joseph P. Zackular
Keyword(s):  
Pharmaceutical Drugs ◽  
Human Gastrointestinal Tract ◽  
Content Type ◽  
The Past ◽  
Clostridioides Difficile ◽  
Wide Range ◽  
Pediatric Populations ◽  
The Impact ◽  
Shed Light

ABSTRACT Clostridioides difficile is a Gram-positive, spore-forming, anaerobic bacterium that infects the human gastrointestinal tract, causing a wide range of disorders that vary in severity from mild diarrhea to toxic megacolon and/or death. Over the past decade, incidence, severity, and costs associated with C. difficile infection (CDI) have increased dramatically in both the pediatric and adult populations. The factors driving this rapidly evolving epidemiology remain largely unknown but are likely due in part to previously unappreciated host, microbiota, and environmental factors. In this review, we will cover the risks and challenges of CDI in adult and pediatric populations and examine asymptomatic colonization in infants. We will also discuss the emerging role of diet, pharmaceutical drugs, and pathogen-microbiota interactions in C. difficile pathogenesis, as well as the impact of host-microbiota interactions in the manifestation of C. difficile-associated disease. Finally, we highlight new areas of research and novel strategies that may shed light on this complex infection and provide insights into the future of microbiota-based therapeutics for CDI.

The role of H2O in the carbonation of forsterite in supercritical CO2

2011 ◽  
Vol 5 (4) ◽  
pp. 1081-1092 ◽  
Author(s):  
Ja Hun Kwak ◽  
Jian Zhi Hu ◽  
Romulus V.F. Turcu ◽  
Kevin M. Rosso ◽  
Eugene S. Ilton ◽  
...  
Keyword(s):  
Supercritical Co2

scholarly journals Recent advances in the use of Langmuir monolayers as cell membrane models

2021 ◽  
Vol 46 (1SI) ◽  
pp. 18-29
Author(s):  
Andressa Ribeiro Pereira ◽  
Osvaldo Novais de Oliveira Junior
Keyword(s):  
Cell Membrane ◽  
Review Paper ◽  
Molecular Level ◽  
Langmuir Monolayers ◽  
Pharmaceutical Drugs ◽  
Membrane Composition ◽  
Biologically Relevant ◽  
Membrane Models ◽  
Biologically Relevant Molecules

Understanding the role of biomolecules in cells at the molecular level has been the trade of Prof. Marcio Francisco Colombo and Prof. Jo�o Ruggiero Neto in their carriers, which is why it was found appropriate to address the use of Langmuir monolayers as cell membrane models in this special issue. In the review paper, we elaborate upon the reasons why Langmuir monolayers are good models with the possible control of membrane composition and molecular packing. After describing several experimental methods to characterize the Langmuir monolayers, we discuss selected results from the last five years where monolayers were made to interact with pharmaceutical drugs, emerging pollutants and other biologically-relevant molecules. The challenges to take the field forward are also commented upon.

Dual role of PDMS on improving supercritical CO2 foaming of polypropylene: CO2-philic additive and crystallization nucleating agent

2020 ◽  
Vol 163 ◽  
pp. 104888
Author(s):  
Wei Qiang ◽  
Ling Zhao ◽  
Xiulu Gao ◽  
Tao Liu ◽  
Zhen Liu ◽  
...  
Keyword(s):  
Supercritical Co2 ◽  
Nucleating Agent ◽  
Dual Role

scholarly journals Microbiome and Human Aging: Probiotic and Prebiotic Potentials in Longevity, Skin Health and Cellular Senescence

Nutrients ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 4550
Author(s):  
Jacqueline Lena Boyajian ◽  
Merry Ghebretatios ◽  
Sabrina Schaly ◽  
Paromita Islam ◽  
Satya Prakash
Keyword(s):  
Cellular Senescence ◽  
Healthy Aging ◽  
Pharmaceutical Drugs ◽  
Human Aging ◽  
Extracellular Matrix Components ◽  
Response To Stress ◽  
Dermatological Disorders ◽  
Immunomodulatory Therapies ◽  
The Relationship

The role of the microbiome in human aging is important: the microbiome directly impacts aging through the gastrointestinal system. However, the microbial impact on skin has yet to be fully understood. For example, cellular senescence is an intrinsic aging process that has been recently associated with microbial imbalance. With age, cells become senescent in response to stress wherein they undergo irreversible growth arrest while maintaining high metabolic activity. An accumulation of senescent cells has been linked to various aging and chronic pathologies due to an overexpression of the senescence-associated secretory phenotype (SASP) comprised of proinflammatory cytokines, chemokines, growth factors, proteases, lipids and extracellular matrix components. In particular, dermatological disorders may be promoted by senescence as the skin is a common site of accumulation. The gut microbiota influences cellular senescence and skin disruption through the gut-skin axis and secretion of microbial metabolites. Metabolomics can be used to identify and quantify metabolites involved in senescence. Moreover, novel anti-senescent therapeutics are warranted given the poor safety profiles of current pharmaceutical drugs. Probiotics and prebiotics may be effective alternatives, considering the relationship between the microbiome and healthy aging. However, further research on gut composition under a senescent status is needed to develop immunomodulatory therapies.

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