Zinc Ions Modify Calcium Oxalate Growth by Distinct Transformation of Crystal Surface Termination

2021 ◽  
Author(s):  
Bryan G. Alamani ◽  
Julian D. Gale ◽  
Jeffrey D. Rimer
Keyword(s):  
Calcium Oxalate ◽  
Crystal Surface ◽  
Zinc Ions ◽  
Surface Termination ◽  
Distinct Transformation

Controlling Crystal Surface Termination by Cleavage Direction

2001 ◽  
Vol 86 (22) ◽  
pp. 5070-5072 ◽  
Author(s):  
M. Plomp ◽  
W. J. P. van Enckevort ◽  
E. Vlieg
Keyword(s):  
Crystal Surface ◽  
Surface Termination

Intracrystalline urinary proteins facilitate degradation and dissolution of calcium oxalate crystals in cultured renal cells

2008 ◽  
Vol 294 (2) ◽  
pp. F355-F361 ◽  
Author(s):  
Phulwinder K. Grover ◽  
Lauren A. Thurgood ◽  
David E. Fleming ◽  
Wilhelm van Bronswijk ◽  
Tingting Wang ◽  
...  
Keyword(s):  
Calcium Oxalate ◽  
Crystallite Size ◽  
Surface Area ◽  
Crystal Surface ◽  
Scanning Electron Micrographs ◽  
Radioactive Label ◽  
Crystal Dissolution ◽  
Mdckii Cells ◽  
Nonuniform Strain ◽  
Scanning Electron

We have previously proposed that intracrystalline proteins would increase intracellular proteolytic disruption and dissolution of calcium oxalate (CaOx) crystals. Chauvet MC, Ryall RL. J Struct Biol 151: 12–17, 2005; Fleming DE, van Riessen A, Chauvet MC, Grover PK, Hunter B, van Bronswijk W, Ryall RL. J Bone Miner Res 18: 1282–1291, 2003; Ryall RL, Fleming DE, Doyle IR, Evans NA, Dean CJ, Marshall VR. J Struct Biol 134: 5–14, 2001. The aim of this investigation was to determine the effect of increasing concentrations of intracrystalline protein on the rate of CaOx crystal dissolution in Madin-Darby canine kidney (MDCKII) cells. Crystal matrix extract (CME) was isolated from urinary CaOx monohydrate (COM) crystals. Cold and [14C]oxalate-labeled COM crystals were precipitated from ultrafiltered urine containing 0–5 mg/l CME. Crystal surface area was estimated from scanning electron micrographs, and synchrotron X-ray diffraction was used to determine nonuniform strain and crystallite size. Radiolabeled crystals were added to MDCKII cells and crystal dissolution, expressed as radioactive label released into the medium, was measured. Increasing CME content did not significantly alter crystal surface area. However, nonuniform strain increased and crystallite size decreased in a dose-response manner, both reaching saturation at a CME concentration of 3 mg/ and demonstrating unequivocally the inclusion of increasing quantities of proteins in the crystals. This was confirmed by Western blotting. Crystal dissolution also followed saturation kinetics, increasing proportionally with final CME concentration and reaching a plateau at a concentration of ∼2 mg/l. These findings were complemented by field emission scanning electron microscopy, which showed that crystal degradation also increased relative to CME concentration. Intracrystalline proteins enhance degradation and dissolution of CaOx crystals and thus may constitute a natural defense against urolithiasis. The findings have significant ramifications in biomineral metabolism and pathogenesis of renal stones.

Urinary crystal surface binding substances on calcium oxalate crystals

1990 ◽  
Vol 18 (6) ◽  
pp. 387-392 ◽  
Author(s):  
T. Koide ◽  
T. Yoshioka ◽  
S. Yamaguchi ◽  
S. Hosokawa ◽  
M. Utsunomiya ◽  
...  
Keyword(s):  
Calcium Oxalate ◽  
Crystal Surface ◽  
Calcium Oxalate Crystals ◽  
Surface Binding ◽  
Oxalate Crystals

The role of zinc ions in calcium oxalate monohydrate crystallization

2020 ◽  
Vol 546 ◽  
pp. 125777 ◽  
Author(s):  
Timothy Barker ◽  
Matthew Boon ◽  
Franca Jones
Keyword(s):  
Calcium Oxalate ◽  
Calcium Oxalate Monohydrate ◽  
Zinc Ions

scholarly journals Inhibition of Calcium Oxalate Formation and Antioxidant Activity of Carboxymethylated Poria cocos Polysaccharides

2021 ◽  
Vol 2021 ◽  
pp. 1-19
Author(s):  
Chuang-Ye Li ◽  
Li Liu ◽  
Yao-Wang Zhao ◽  
Jia-Yun Chen ◽  
Xin-Yuan Sun ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Calcium Oxalate ◽  
Crystal Surface ◽  
Human Kidney ◽  
Calcium Oxalate Monohydrate ◽  
Ferrous Ions ◽  
Calcium Oxalate Dihydrate ◽  
Poria Cocos ◽  
Oxidative Damages ◽  
Proximal Tubular Epithelial Cells

Three carboxymethylated Poria cocos polysaccharides (PCP-C1, PCP-C2, and PCP-C3) with -COOH contents of 6.13%, 10.24%, and 16.22%, respectively, were obtained by carboxymethylation of the original polysaccharide (PCP-C0), which has a molecular weight of 4 kDa and a carboxyl (-COOH) content of 2.54%. The structure of the PCP-Cs was characterized by FT-IR, 1H NMR, and 13C NMR spectra. The four PCP-Cs exhibited antioxidant activity, and their ability to scavenge radicals (hydroxyl and DPPH) and chelate ferrous ions was positively correlated with the degree of carboxymethylation. As the content of -COOH groups in the PCP-Cs increases, their ability to regulate the growth of calcium oxalate (CaOx) crystals was enhanced, thus inhibiting the growth of calcium oxalate monohydrate (COM) crystals and inducing the formation of more calcium oxalate dihydrate (COD) crystals. The formed CaOx crystal was more round and blunt, the absolute value of the Zeta potential on the crystal surface increased, and the aggregation between crystals was inhibited. Thermogravimetric analysis curves showed that the proportions of PCP-C0, PCP-C1, PCP-C2, and PCP-C3 incorporated into the crystal were 20.52%, 15.60%, 10.65%, and 9.78%, respectively, in the presence of 0.4 g/L PCP-Cs. PCP-C protection resisted oxidative damages of human kidney proximal tubular epithelial cells (HK-2) caused by oxalate, resulting in increased cell viability and superoxide dismutase activity and decreased reactive oxygen species levels, malondialdehyde content, and 8-hydroxy-deoxyguanosine expression. Hence, PCP-Cs, especially PCP-C3, can inhibit the formation of CaOx crystals and may have the potential to be an alternative antistone drug.

Wide-angle resonance of a photonic crystal surface mode under a surface termination and its influence on imaging

2016 ◽  
Vol 19 (1) ◽  
pp. 015101
Author(s):  
Hengrun Hu ◽  
Hongmei Liu ◽  
Yun Qing ◽  
Lu-Teng Cheng ◽  
Weiwei Song ◽  
...  
Keyword(s):  
Photonic Crystal ◽  
Crystal Surface ◽  
Surface Mode ◽  
Wide Angle ◽  
Surface Termination

Glycosaminoglycans in Crystal-Surface Binding Substances and Their Role in Calcium Oxalate Crystal Growth

1998 ◽  
Vol 159 (5) ◽  
pp. 1780-1780
Author(s):  
K. Yoshimura ◽  
T. Yoshioka ◽  
O. Miyake ◽  
M. Honda ◽  
S. Yamaguchi ◽  
...  
Keyword(s):  
Crystal Growth ◽  
Calcium Oxalate ◽  
Crystal Surface ◽  
Calcium Oxalate Crystal ◽  
Surface Binding

Influence of Chondroitin Sulfate A on Zeta Potential, Aggregation and Sedimentation of Nano COM and Nano COD Crystallites

2014 ◽  
Vol 952 ◽  
pp. 38-42
Author(s):  
Lan Qing Deng ◽  
Jun Fa Xue ◽  
Cai Yan Tang ◽  
Yu Shan Xie ◽  
Jian Ming Ouyang
Keyword(s):  
Zeta Potential ◽  
Calcium Oxalate ◽  
Chondroitin Sulfate ◽  
Crystal Surface ◽  
Calcium Oxalate Monohydrate ◽  
Calcium Oxalate Dihydrate ◽  
Absolute Value ◽  
Transmission Electron ◽  
The Stability ◽  
Chondroitin Sulfate A

The influence of urinary macromolecule chondroitin sulfate A (C4S) on Zeta potential, aggregation and sedimentation of calcium oxalate monohydrate (COM) and calcium oxalate dihydrate (COD) nanocrystallites with a diameter of about 50 nm were investigated using nanoparticle size Zeta potential analyzer and transmission electron microscope. C4S could increase the absolute value of Zeta potential on surface of nanoCOM and nanoCOD crystallites by adsorbing on crystal surface, it led an increase of the electrostatic repulsion force between the crystallites, so the aggregation and sedimentation of these crystallites were inhibited, and the stability of the suspension of nanoCOM and nanoCOD was improved. In conclusion, C4S could inhibit the formation of CaOxa stones。

Glycosaminoglycans in crystal-surface binding substances and their role in calcium oxalate crystal growth

1997 ◽  
Vol 80 (1) ◽  
pp. 64-68 ◽  
Author(s):  
K. YOSHIMURA ◽  
T. YOSHIOKA ◽  
O. MIYAKE ◽  
M. HONDA ◽  
S. YAMAGUCHI ◽  
...  
Keyword(s):  
Crystal Growth ◽  
Calcium Oxalate ◽  
Crystal Surface ◽  
Calcium Oxalate Crystal ◽  
Surface Binding
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