Predicting Calcite Crystallization and Inhibition Kinetics at up to 175 °C Using a New Theoretical Inhibition Model

2020 ◽  
Vol 20 (12) ◽  
pp. 8090-8100
Author(s):  
Zhaoyi Dai ◽  
Fangfu Zhang ◽  
Yue Zhao ◽  
Chong Dai ◽  
Xin Wang ◽  
...  
Keyword(s):  
Inhibition Kinetics ◽  
Inhibition Model

The inhibition model of DDoS attacks in SDN networks

2017 ◽  
Vol 34 (6) ◽  
pp. 562
Author(s):  
Qiao Yan ◽  
Qingxiang Gong ◽  
Fei Yu
Keyword(s):  
Ddos Attacks ◽  
Inhibition Model

Inhibition kinetics for propionate degradation using propionate-enriched mixed cultures

1998 ◽  
Vol 38 (8-9) ◽  
pp. 443-451 ◽  
Author(s):  
S. H. Hyun ◽  
J. C. Young ◽  
I. S. Kim
Keyword(s):  
Phase I ◽  
Competitive Inhibition ◽  
Gas Production ◽  
Phase Iii ◽  
Utilization Rate ◽  
Inhibition Kinetics ◽  
Wide Range ◽  
Propionate Degradation ◽  
Acetate Utilization ◽  
Velocity Coefficient

To study propionate inhibition kinetics, seed cultures for the experiment were obtained from a propionate-enriched steady-state anaerobic Master Culture Reactor (MCR) operated under a semi-continuous mode for over six months. The MCR received a loading of 1.0 g propionate COD/l-day and was maintained at a temperature of 35±1°C. Tests using serum bottle reactors consisted of four phases. Phase I tests were conducted for measurement of anaerobic gas production as a screening step for a wide range of propionate concentrations. Phase II was a repeat of phase I but with more frequent sampling and detailed analysis of components in the liquid sample using gas chromatography. In phase III, different concentrations of acetate were added along with 1.0 g propionate COD/l to observe acetate inhibition of propionate degradation. Finally in phase IV, different concentrations of propionate were added along with 100 and 200 mg acetate/l to confirm the effect of mutual inhibition. Biokinetic and inhibition coefficients were obtained using models of Monod, Haldane, and Han and Levenspiel through the use of non-linear curve fitting technique. Results showed that the values of kp, maximum propionate utilization rate, and Ksp, half-velocity coefficient for propionate conversion, were 0.257 mg HPr/mg VSS-hr and 200 mg HPr/l, respectively. The values of kA, maximum acetate utilization rate, and KsA, half-velocity coefficient for acetate conversion, were 0.216 mg HAc/mg VSS-hr and 58 mg HAc/l, respectively. The results of phase III and IV tests indicated there was non-competitive inhibition when the acetate concentration in the reactor exceeded 200 mg/l.

Inhibition Kinetics of 16 Organophosphorus Pesticides or Their Active Metabolites on Erythrocyte Acetylcholinesterase from Humans and Rats

2021 ◽  
Author(s):  
Edward C Meek ◽  
Richard Reiss ◽  
J Allen Crow ◽  
Janice E Chambers
Keyword(s):  
Kinetic Parameters ◽  
Organophosphorus Pesticides ◽  
Erythrocyte Ghost ◽  
Inhibition Kinetics ◽  
Active Metabolites ◽  
Adult Rats ◽  
Resultant Data ◽  
Wide Range ◽  
High Level ◽  
Pooled Samples

Abstract Inhibition kinetics assays were conducted with 16 commercial organophosphate (OP) pesticides or their metabolites on acetylcholinesterase (AChE) in erythrocyte “ghost” preparations from 18 individual humans (both sexes; adults, juveniles and cord blood samples; mixed races/ethnicities) and pooled samples from adult rats (both sexes). A well established spectrophotometric assay using acetylthiocholine as substrate and a chromogen was employed. The kinetic parameters bimolecular rate constant (ki), dissociation constant (KI) and phosphorylation constant (kp) were calculated for each compound. As expected, a wide range of potencies were displayed among the tested compounds. Statistical analysis of the resultant data indicated no differences in sex, age or race/ethnicity among the human samples that are unexpected based on chance (4.2% statistically significant out of 48 parameters calculated) and no differences between the sexes in rats. The bimolecular rate constants for 10 of the compounds were not statistically different between rats and humans. The data indicate that, consistent with the high level of conservation of AChE among species and the fact that AChE at different locations within a species arises from the same gene, the inhibition kinetic parameters calculated from rat erythrocyte ghost preparations should be useful in estimating potencies of OP compounds on target AChE in humans. Additionally the data indicate that differences in sensitivities among individual humans were not apparent. Impact Statement: These data are expected to be useful in consideration of the intraspecies and interspecies uncertainty factors in OP pesticide risk assessment.

On the interpretation of tyrosinase inhibition kinetics

2013 ◽  
Vol 29 (1) ◽  
pp. 92-99 ◽  
Author(s):  
Wei Sun ◽  
Michael Wendt ◽  
Gerhard Klebe ◽  
Klaus-Heinrich Röhm
Keyword(s):  
Inhibition Kinetics ◽  
Tyrosinase Inhibition

Inhibition kinetics and selectivity of the tyrosine kinase inhibitor erbstatin and a pyridone-based analogue

1992 ◽  
Vol 43 (11) ◽  
pp. 2471-2477 ◽  
Author(s):  
Chin-Yi Jenny Hsu ◽  
Mary V. Jacoski ◽  
Martin P. Maguire ◽  
Alfred P. Spada ◽  
Asher Zilberstein
Keyword(s):  
Tyrosine Kinase ◽  
Tyrosine Kinase Inhibitor ◽  
Kinase Inhibitor ◽  
Inhibition Kinetics
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