Surface Coassembly of Polymer Brushes and Polymer–Protein Bioconjugates: An Efficient Approach to the Purification of Bioconjugates under Mild Conditions

2018 ◽  
Vol 19 (11) ◽  
pp. 4463-4471 ◽  
Author(s):  
Wangmeng Hou ◽  
Lin Wei ◽  
Li Liu ◽  
Hanying Zhao
Keyword(s):  
Polymer Brushes ◽  
Efficient Approach ◽  
Mild Conditions

scholarly journals Conformation Study of Dual Stimuli-Responsive Core-Shell Diblock Polymer Brushes

Polymers ◽  
2018 ◽  
Vol 10 (10) ◽  
pp. 1084
Author(s):  
Kaimin Chen ◽  
Lan Cao ◽  
Ying Zhang ◽  
Kai Li ◽  
Xue Qin ◽  
...  
Keyword(s):  
Polymer Brushes ◽  
Core Shell ◽  
Stimuli Responsive ◽  
Research Topics ◽  
Design And Synthesis ◽  
Mild Conditions ◽  
The Core ◽  
Responsive Polymer ◽  
Stimuli Responsive Polymer ◽  
Shed Light

Stimuli-responsive nanoparticles are among the most popular research topics. In this study, two types of core-shell (polystyrene with a photoiniferter (PSV) as the core and diblock as the shell) polymer brushes (PSV@PNIPA-b-PAA and PSV@PAA-b-PNIPA) were designed and prepared using surface-initiated photoiniferter-mediated polymerization (SI-PIMP). Moreover, their pH- and temperature-stimuli responses were explored by dynamic light scattering (DLS) and turbidimeter under various conditions. The results showed that the conformational change was determined on the basis of the competition among electrostatic repulsion, hydrophobic interaction, hydrogen bonding, and steric hindrance, which was also confirmed by protein adsorption experiments. These results are not only helpful for the design and synthesis of stimuli-responsive polymer brushes but also shed light on controlled protein immobilization under mild conditions.

Halogen-Radical-Promoted Dearomative Aza-Spirocyclization of Alkynylimines: An Efficient Approach to 3-Halo-Spirocyclohexadienones

Synthesis ◽  
2019 ◽  
Vol 52 (04) ◽  
pp. 609-618 ◽  
Author(s):  
Dianpeng Chen ◽  
Jianming Li ◽  
Yingying Shan ◽  
Peiying Cui ◽  
Yutong Zhao ◽  
...  
Keyword(s):  
Radical Addition ◽  
Efficient Approach ◽  
Mild Conditions ◽  
Halogen Radical

A novel halogen-radical-promoted dearomative aza-spiro­cyclization of alkynylimines for the synthesis of 3-halo-spirocyclohexadienones is described. In this process, it is believed that a radical addition, 5-exo-trig cyclization, and dearomative aza-spirocyclization are involved. Easily available starting materials, mild conditions, and a wide substrate scope make this approach potentially useful.

Palladium-catalyzed [4 + 3] dearomatizing cycloaddition reaction of N-iminoquinolinium ylides

2020 ◽  
Vol 7 (18) ◽  
pp. 2612-2617
Author(s):  
Wenhao Dai ◽  
Chunpu Li ◽  
Yichu Liu ◽  
Xu Han ◽  
Xingjun Li ◽  
...  
Keyword(s):  
Functional Group ◽  
Cycloaddition Reaction ◽  
Membered Ring ◽  
Efficient Approach ◽  
Mild Conditions ◽  
Palladium Catalyzed

An efficient approach to obtain saturated seven-membered ring containing three heteroatoms has been developed by using a palladium-catalyzed [4 + 3] dearomatizing cycloaddition. This approach features mild conditions and good functional group tolerance.

scholarly journals Nickel-catalyzed asymmetric hydrogenation of β-acylamino nitroolefins: an efficient approach to chiral amines

2017 ◽  
Vol 8 (9) ◽  
pp. 6419-6422 ◽  
Author(s):  
Wenchao Gao ◽  
Hui Lv ◽  
Tonghuan Zhang ◽  
Yuhong Yang ◽  
Lung Wa Chung ◽  
...  
Keyword(s):  
Asymmetric Hydrogenation ◽  
Chiral Amines ◽  
Efficient Approach ◽  
Mild Conditions

The Ni-catalyzed asymmetric hydrogenation of challenging β-acylamino nitroolefins was achieved under mild conditions, affording β-acylamino nitroalkanes in excellent yields and with high enantioselectivities.

scholarly journals Application of One-Pot Three-Component Condensation Reaction for the Synthesis of New Organophosphorus–Sulfur Macrocycles

Synlett ◽  
2018 ◽  
Vol 29 (11) ◽  
pp. 1496-1501 ◽  
Author(s):  
J. Woollins ◽  
Guoxiong Hua ◽  
David Cordes ◽  
Alexandra Slawin
Keyword(s):  
Multicomponent Reaction ◽  
Room Temperature ◽  
Condensation Reaction ◽  
Synthesis Method ◽  
Membered Ring ◽  
One Pot ◽  
X Ray ◽  
Efficient Approach ◽  
Mild Conditions ◽  
Sulfur Heterocycles

An efficient approach has been developed for the synthesis of new phosphorus–sulfur heterocycles by a one-pot three-component condensation reaction of a four-membered-ring thionation reagent [Lawesson’s reagent or its ferrocene analogue (2,4-diferrocenyl-1,3,2,4-diathiadiphosphetane 2,4-disulfide)], an alkane- or arenedithiol, and a dihaloalkane at room temperature in the presence of triethylamine. The simple synthesis method with mild conditions (room temperature and normal reactant concentrations) enhances further the application of the multicomponent reaction in the preparation of novel phosphorus–sulfur heterocycles. Six representative X-ray structures confirmed the formation of these macrocycles.

A Concise and Efficient Approach to 2,6-Disubstituted 4-Fluoro­pyrimidines from α-CF3 Aryl Ketones

Synthesis ◽  
2019 ◽  
Vol 52 (02) ◽  
pp. 273-280 ◽  
Author(s):  
Fangran Liu ◽  
Xiaofei Zhang ◽  
Qun Qian ◽  
Chunhao Yang
Keyword(s):  
Medicinal Chemistry ◽  
Building Blocks ◽  
Practical Approach ◽  
Efficient Approach ◽  
Mild Conditions ◽  
Aryl Ketones

Herein, a concise and efficient protocol to synthesize a series of 2,6-disubstituted 4-fluoropyrimidines as universal and useful building blocks in medicinal chemistry is reported. From readily accessible α-CF3 aryl ketones and different amidine hydrochlorides, this method provides a very practical approach to this kind of compounds under mild conditions with good to excellent yields.

p-Toluenesulfonic Acid Induced Conversion of Fluorinated Trimethylsilylethynylanilines into Aminoacetophenones: Versatile Precursors for the Synthesis of Benzoazaheterocycles

Synthesis ◽  
2017 ◽  
Vol 50 (03) ◽  
pp. 555-564 ◽  
Author(s):  
Larisa Politanskaya ◽  
Evgeny Tretyakov
Keyword(s):  
Metal Free ◽  
Efficient Approach ◽  
Mild Conditions ◽  
Toluenesulfonic Acid

A simple and efficient approach to the synthesis of fluorinated amino-substituted acetophenones in good to excellent yields is reported. The heart of the proposed method consists of conversion of a Me3Si–C≡C– moiety into a MeC(=O)– group in the presence of p-tolu­ene­sulfonic acid (p-TSA) passing a stage of ethynylaniline formation. The reaction is metal-free, proceeds under mild conditions, and uses readily available starting compounds (trimethylsilylarylacetylene derivatives). The reaction provides access to amino-substituted acetophenones, which may serve as precursors for the synthesis of polyfluorinated azaheterocycles, having potential anticarcinogenic activity.

An unexpected rearrangement of pyrazolium halides based on N–N bond cleavage: synthesis of 1,2-dihydropyrimidines

2017 ◽  
Vol 53 (50) ◽  
pp. 6792-6795 ◽  
Author(s):  
Qian Chen ◽  
Xiaoshuang Liu ◽  
Fang Guo ◽  
Zhonglin Chen
Keyword(s):  
Bond Cleavage ◽  
Efficient Approach ◽  
Mild Conditions

An unexpected rearrangement of pyrazolium halides was observed, presenting an efficient approach for the synthesis of 1,2-dihydroquinazolines under mild conditions.

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