Fine Tuning of Core–Shell Structure of Hyaluronic Acid/Cell-Penetrating Peptides/siRNA Nanoparticles for Enhanced Gene Delivery to Macrophages in Antiatherosclerotic Therapy

2018 ◽  
Vol 19 (7) ◽  
pp. 2944-2956 ◽  
Author(s):  
Yi Zhao ◽  
Zhiyu He ◽  
Hai Gao ◽  
Haoyu Tang ◽  
Jianhua He ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Gene Delivery ◽  
Shell Structure ◽  
Cell Penetrating Peptides ◽  
Fine Tuning ◽  
Core Shell ◽  
Antiatherosclerotic Therapy ◽  
Cell Penetrating ◽  
Core Shell Structure

scholarly journals Dually Cross-Linked Core-Shell Structure Nanohydrogel with Redox–Responsive Degradability for Intracellular Delivery

Pharmaceutics ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 2048
Author(s):  
Siyuan Deng ◽  
Maria Rosa Gigliobianco ◽  
Yimin Mijiti ◽  
Marco Minicucci ◽  
Manuela Cortese ◽  
...  
Keyword(s):  
Particle Size ◽  
Hyaluronic Acid ◽  
Cytochrome C ◽  
Horseradish Peroxidase ◽  
Shell Structure ◽  
Intracellular Delivery ◽  
Core Shell ◽  
Hydroxypropyl Methacrylamide ◽  
Redox Responsive ◽  
Core Shell Structure

A redox-responsive nanocarrier is a promising strategy for the intracellular drug release because it protects the payload, prevents its undesirable leakage during extracellular transport, and favors site-specific drug delivery. In this study, we developed a novel redox responsive core-shell structure nanohydrogel prepared by a water in oil nanoemulsion method using two biocompatible synthetic polymers: vinyl sulfonated poly(N-(2-hydroxypropyl) methacrylamide mono/dilactate)-polyethylene glycol-poly(N-(2-hydroxypropyl) methacrylamide mono/dilactate) triblock copolymer, and thiolated hyaluronic acid. The influence on the nanohydrogel particle size and distribution of formulation parameters was investigated by a three-level full factorial design to optimize the preparation conditions. The surface and core-shell morphology of the nanohydrogel were observed by scanning electron microscope, transmission electron microscopy, and further confirmed by Fourier transform infrared spectroscopy and Raman spectroscopy from the standpoint of chemical composition. The redox-responsive biodegradability of the nanohydrogel in reducing environments was determined using glutathione as reducing agent. A nanohydrogel with particle size around 250 nm and polydispersity index around 0.1 is characterized by a thermosensitive shell which jellifies at body temperature and crosslinks at the interface of a redox-responsive hyaluronic acid core via the Michael addition reaction. The nanohydrogel showed good encapsulation efficiency for model macromolecules of different molecular weight (93% for cytochrome C, 47% for horseradish peroxidase, and 90% for bovine serum albumin), capacity to retain the peroxidase-like enzymatic activity (around 90%) of cytochrome C and horseradish peroxidase, and specific redox-responsive release behavior. Additionally, the nanohydrogel exhibited excellent cytocompatibility and internalization efficiency into macrophages. Therefore, the developed core-shell structure nanohydrogel can be considered a promising tool for the potential intracellular delivery of different pharmaceutical applications, including for cancer therapy.

Electrical Conductivity of Ni-YSZ Anode for SOFCs According to the Ni Powder Size Variations in Core-shell Structure

2015 ◽  
Vol 53 (4) ◽  
pp. 287-293
Author(s):  
Byung-Hyun Choi ◽  
Young Jin Kang ◽  
Sung-Hun Jung ◽  
Yong-Tae An ◽  
Mi-Jung Ji
Keyword(s):  
Electrical Conductivity ◽  
Shell Structure ◽  
Core Shell ◽  
Powder Size ◽  
Ni Powder ◽  
Core Shell Structure

Preparation of Porous Core/Shell Structure Fe$lt;inf$gt;2$lt;/inf$gt;O$lt;inf$gt;3$lt;/inf$gt;/Al Nanothermite Membrane by Template Method

2015 ◽  
Vol 30 (6) ◽  
pp. 610 ◽  
Author(s):  
ZHENG Guo-Qiang ◽  
ZHANG Wen-Chao ◽  
XU Xing ◽  
SHEN Rui-Qi ◽  
DENG Ji-Ping ◽  
...  
Keyword(s):  
Shell Structure ◽  
Template Method ◽  
Core Shell ◽  
Porous Core ◽  
Core Shell Structure

Functional properties of BaTiO3–Ni0.5Zn0.5Fe2O4 magnetoelectric ceramics prepared from powders with core-shell structure

2010 ◽  
Vol 107 (10) ◽  
pp. 104106 ◽  
Author(s):  
L. P. Curecheriu ◽  
M. T. Buscaglia ◽  
V. Buscaglia ◽  
L. Mitoseriu ◽  
P. Postolache ◽  
...  
Keyword(s):  
Functional Properties ◽  
Shell Structure ◽  
Core Shell ◽  
Core Shell Structure

scholarly journals Ternary ZnO/Co3O4/NiO inherited layered core-shell structure from a double template for high performanced supercapacitor

2021 ◽  
Author(s):  
Linli Zhu ◽  
Chen Hao ◽  
Saisai Zhou ◽  
Xiaohong Wang ◽  
Tiantian Zhou ◽  
...  
Keyword(s):  
Shell Structure ◽  
Core Shell ◽  
Core Shell Structure

Composite nanoparticles with titania–poly(N-vinylamide) core–shell structure

2021 ◽  
Vol 31 (1) ◽  
pp. 24-26
Author(s):  
Galina M. Kuz’micheva ◽  
Olesya I. Timaeva ◽  
Irina P. Chikhacheva ◽  
Roman V. Svetogorov ◽  
Ratibor G. Chumakov ◽  
...  
Keyword(s):  
Shell Structure ◽  
Composite Nanoparticles ◽  
Core Shell ◽  
Core Shell Structure

Designing an Interlayer-Widened MoS2-Packed Nitrogen-Rich Carbon Nanotube Core–Shell Structure for Redox-Mediated Quasi-Solid-State Supercapacitors

2021 ◽  
Vol 4 (3) ◽  
pp. 2218-2230
Author(s):  
Sudhakaran Moopri Singer Pandiyarajan ◽  
Ganesh Kumar Veerasubramani ◽  
Roshan Mangal Bhattarai ◽  
Gnanaselvan Gnanasekaran ◽  
Sang Jae Kim ◽  
...  
Keyword(s):  
Carbon Nanotube ◽  
Solid State ◽  
Shell Structure ◽  
Core Shell ◽  
Core Shell Structure

Preparation and electrochemical properties of novel silicon-carbon composite anode materials with a core-shell structure

Carbon ◽  
2021 ◽  
Vol 179 ◽  
pp. 702
Author(s):  
Heng-chao Jin ◽  
Qian Sun ◽  
Ji-tong Wang ◽  
M.A. Chen ◽  
Li-cheng Ling ◽  
...  
Keyword(s):  
Electrochemical Properties ◽  
Shell Structure ◽  
Anode Materials ◽  
Carbon Composite ◽  
Core Shell ◽  
Composite Anode ◽  
Silicon Carbon ◽  
Core Shell Structure
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