Transition State Analogues Enhanced by Fragment-Based Structural Analysis: Bacterial Methylthioadenosine Nucleosidases

Biochemistry ◽  
2020 ◽  
Vol 59 (7) ◽  
pp. 831-835
Author(s):  
Di Zhang ◽  
Brandon E. Burdette ◽  
Zhengyu Wang ◽  
Kumari Karn ◽  
Hong-yu Li ◽  
...  
Keyword(s):  
Structural Analysis ◽  
Transition State ◽  
Transition State Analogues

scholarly journals New human renin inhibitory peptides. Angiotensinogen transition-state analogues containing novel Leu-Val replacement and a retro-inverso amide bond.

1988 ◽  
Vol 36 (6) ◽  
pp. 2278-2281 ◽  
Author(s):  
Kinji Iizuka ◽  
Tetsuhide Kamijo ◽  
Hiromu Harada ◽  
Kenji Akahane ◽  
Tetsuhiro Kubota ◽  
...  
Keyword(s):  
Transition State ◽  
Amide Bond ◽  
Inhibitory Peptides ◽  
Transition State Analogues ◽  
Human Renin

scholarly journals Tight Binding of Transition-State Analogues to a Peptidyl-Aminoacyl-L/D-Isomerase from Frog Skin

ChemBioChem ◽  
2011 ◽  
Vol 12 (13) ◽  
pp. 1996-2000 ◽  
Author(s):  
Verena Gehmayr ◽  
Christa Mollay ◽  
Lorenz Reith ◽  
Norbert Müller ◽  
Alexander Jilek
Keyword(s):  
Transition State ◽  
Frog Skin ◽  
Tight Binding ◽  
Transition State Analogues

scholarly journals Polyvalent transition-state analogues of sialyl substrates strongly inhibit bacterial sialidases.

2020 ◽  
Author(s):  
coralie assailly ◽  
clarisse bridot ◽  
amélie saumonneau ◽  
paul lottin ◽  
Benoit Roubinet ◽  
...  
Keyword(s):  
Transition State ◽  
Important Class ◽  
Inhibitory Potency ◽  
Polymeric Scaffolds ◽  
Transition State Analogues

<div>Conjugation of the transitionstate-cation analogue DANA to polymeric scaffolds led to highly potent inhibitors of bacterial sialidases. Each clustered DANA on the polymers saw its inhibitory potency for S. pneumoniae or B. thetaiotaomicron sialidases improved by more than four orders of magnitude. This extends the multivalent concept to this important class of enzymes.</div><div><br></div>

scholarly journals Transition-State Analogues of Phenylethanolamine N-Methyltransferase

2020 ◽  
Vol 142 (33) ◽  
pp. 14222-14233 ◽  
Author(s):  
Niusha Mahmoodi ◽  
Rajesh K. Harijan ◽  
Vern L. Schramm
Keyword(s):  
Transition State ◽  
Transition State Analogues

scholarly journals Crystal Structures ofStaphylococcus aureusKetol-Acid Reductoisomerase in Complex with Two Transition State Analogues that Have Biocidal Activity

2017 ◽  
Vol 23 (72) ◽  
pp. 18289-18295 ◽  
Author(s):  
Khushboo M. Patel ◽  
David Teran ◽  
Shan Zheng ◽  
Ajit Kandale ◽  
Mario Garcia ◽  
...  
Keyword(s):  
Transition State ◽  
Crystal Structures ◽  
Biocidal Activity ◽  
Transition State Analogues
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