scholarly journals X-ray Crystal Structures of the Influenza M2 Proton Channel Drug-Resistant V27A Mutant Bound to a Spiro-Adamantyl Amine Inhibitor Reveal the Mechanism of Adamantane Resistance

Biochemistry ◽  
2020 ◽  
Vol 59 (4) ◽  
pp. 627-634 ◽  
Author(s):  
Jessica L. Thomaston ◽  
Athina Konstantinidi ◽  
Lijun Liu ◽  
George Lambrinidis ◽  
Jingquan Tan ◽  
...  
Keyword(s):  
Crystal Structures ◽  
Proton Channel ◽  
Drug Resistant ◽  
X Ray ◽  
M2 Proton Channel

scholarly journals Crystal structure of the drug-resistant S31N influenza M2 proton channel

2016 ◽  
Vol 25 (8) ◽  
pp. 1551-1554 ◽  
Author(s):  
Jessica L. Thomaston ◽  
William F. DeGrado
Keyword(s):  
Crystal Structure ◽  
Proton Channel ◽  
Drug Resistant ◽  
M2 Proton Channel

scholarly journals X-ray Crystal Structure of the Influenza A M2 Proton Channel S31N Mutant in Two Conformational States: An Open and Shut Case

2019 ◽  
Vol 141 (29) ◽  
pp. 11481-11488 ◽  
Author(s):  
Jessica L. Thomaston ◽  
Yibing Wu ◽  
Nicholas Polizzi ◽  
Lijun Liu ◽  
Jun Wang ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Influenza A ◽  
Proton Channel ◽  
Conformational States ◽  
X Ray ◽  
M2 Proton Channel

Transmission electron microscope studies in special ceramics

1978 ◽  
Vol 36 (1) ◽  
pp. 268-269
Author(s):  
A. Zangvil ◽  
L.J. Gauckler ◽  
G. Schneider ◽  
M. Rühle
Keyword(s):  
Phase Diagrams ◽  
Crystal Structures ◽  
Thin Foil ◽  
Limited Extent ◽  
Complex Materials ◽  
X Ray Diffraction ◽  
X Ray ◽  
Transmission Electron ◽  
Electron Microscopes ◽  
Lattice Resolution

The use of high temperature special ceramics which are usually complex materials based on oxides, nitrides, carbides and borides of silicon and aluminum, is critically dependent on their thermomechanical and other physical properties. The investigations of the phase diagrams, crystal structures and microstructural features are essential for better understanding of the macro-properties. Phase diagrams and crystal structures have been studied mainly by X-ray diffraction (XRD). Transmission electron microscopy (TEM) has contributed to this field to a very limited extent; it has been used more extensively in the study of microstructure, phase transformations and lattice defects. Often only TEM can give solutions to numerous problems in the above fields, since the various phases exist in extremely fine grains and subgrain structures; single crystals of appreciable size are often not available. Examples with some of our experimental results from two multicomponent systems are presented here. The standard ion thinning technique was used for the preparation of thin foil samples, which were then investigated with JEOL 200A and Siemens ELMISKOP 102 (for the lattice resolution work) electron microscopes.

Crystal Structures of Fragments D and Double-D from Fibrinogen and Fibrin

1999 ◽  
Vol 82 (08) ◽  
pp. 271-276 ◽  
Author(s):  
Glen Spraggon ◽  
Stephen Everse ◽  
Russell Doolittle
Keyword(s):  
Electron Microscopy ◽  
High Resolution ◽  
Crystal Structures ◽  
Structure And Function ◽  
X Ray ◽  
Long Period ◽  
And Function

IntroductionAfter a long period of anticipation,1 the last two years have witnessed the first high-resolution x-ray structures of fragments from fibrinogen and fibrin.2-7 The results confirmed many aspects of fibrinogen structure and function that had previously been inferred from electron microscopy and biochemistry and revealed some unexpected features. Several matters have remained stubbornly unsettled, however, and much more work remains to be done. Here, we review several of the most significant findings that have accompanied the new x-ray structures and discuss some of the problems of the fibrinogen-fibrin conversion that remain unresolved. * Abbreviations: GPR—Gly-Pro-Arg-derivatives; GPRPam—Gly-Pro-Arg-Pro-amide; GHRPam—Gly-His-Arg-Pro-amide

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