scholarly journals Discovery of Amidotemplated Natural Product Assembly

Biochemistry ◽  
2019 ◽  
Vol 58 (46) ◽  
pp. 4583-4584
Author(s):  
Evelyn M. Molloy ◽  
Maria Dell ◽  
Christian Hertweck
Keyword(s):  
Natural Product ◽  
Product Assembly

Heterologous Expression and Structural Characterisation of a Pyrazinone Natural Product Assembly Line

ChemBioChem ◽  
2012 ◽  
Vol 13 (16) ◽  
pp. 2408-2415 ◽  
Author(s):  
Morgan A. Wyatt ◽  
M. C. Y. Mok ◽  
Murray Junop ◽  
Nathan A. Magarvey
Keyword(s):  
Heterologous Expression ◽  
Natural Product ◽  
Assembly Line ◽  
Structural Characterisation ◽  
Product Assembly

New insights into the echinocandins and other fungal non-ribosomal peptides and peptaibiotics

2014 ◽  
Vol 31 (10) ◽  
pp. 1348-1375 ◽  
Author(s):  
Gerald Bills ◽  
Yan Li ◽  
Li Chen ◽  
Qun Yue ◽  
Xue-Mei Niu ◽  
...  
Keyword(s):  
Natural Product ◽  
Fungal Metabolites ◽  
Peptide Synthetases ◽  
Product Assembly ◽  
Primary Modality ◽  
Non Ribosomal Peptides

Non-ribosomal peptide synthetases (NRPSs) are a primary modality for fungal peptidic natural product assembly and are responsible for some of the best known, most useful, and most destructive fungal metabolites.

New chemistry from natural product biosynthesis

2016 ◽  
Vol 44 (3) ◽  
pp. 738-744 ◽  
Author(s):  
Catherine B. Hubert ◽  
Sarah M. Barry
Keyword(s):  
Natural Product ◽  
Chemical Reactions ◽  
Bond Activation ◽  
Synthetic Chemistry ◽  
Biosynthetic Pathways ◽  
Natural Product Biosynthesis ◽  
Bulk Chemicals ◽  
Enzyme Discovery ◽  
Starting Point ◽  
Product Assembly

Catalysts are a vital part of synthetic chemistry. However, there are still many important reactions for which catalysts have not been developed. The use of enzymes as biocatalysts for synthetic chemistry is growing in importance due to the drive towards sustainable methods for producing both bulk chemicals and high value compounds such as pharmaceuticals, and due to the ability of enzymes to catalyse chemical reactions with excellent stereoselectivity and regioselectivity. Such challenging transformations are a common feature of natural product biosynthetic pathways. In this mini-review, we discuss the potential to use biosynthetic pathways as a starting point for biocatalyst discovery. We introduce the reader to natural product assembly and tailoring, then focus on four classes of enzyme that catalyse C─H bond activation reactions to functionalize biosynthetic precursors. Finally, we briefly discuss the challenges involved in novel enzyme discovery.

Analysis of the Sorangicin Gene Cluster Reinforces the Utility of a Combined Phylogenetic/Retrobiosynthetic Analysis for Deciphering Natural Product Assembly by trans-AT PKS

ChemBioChem ◽  
2010 ◽  
Vol 11 (13) ◽  
pp. 1840-1849 ◽  
Author(s):  
Herbert Irschik ◽  
Maren Kopp ◽  
Kira J. Weissman ◽  
Kathrin Buntin ◽  
Jörn Piel ◽  
...  
Keyword(s):  
Natural Product ◽  
Gene Cluster ◽  
Product Assembly

Novel Characters of Myxobacterial Modular Natural Product Assembly Lines*

2012 ◽  
Vol 39 (6) ◽  
pp. 525-539 ◽  
Author(s):  
Li-Ping ZHU ◽  
Zhi-Feng Li ◽  
Kui HAN ◽  
Shu-Guang LI ◽  
Yue-Zhong LI
Keyword(s):  
Natural Product ◽  
Assembly Lines ◽  
Product Assembly

Multimodular biocatalysts for natural product assembly

2001 ◽  
Vol 88 (3) ◽  
pp. 93-101 ◽  
Author(s):  
Dirk Schwarzer ◽  
Mohamed A. Marahiel
Keyword(s):  
Natural Product ◽  
Product Assembly

Recent applications of the 1,2-carbon atom migration strategy in complex natural product total synthesis

2017 ◽  
Vol 46 (8) ◽  
pp. 2272-2305 ◽  
Author(s):  
Xiao-Ming Zhang ◽  
Yong-Qiang Tu ◽  
Fu-Min Zhang ◽  
Zhi-Hua Chen ◽  
Shao-Hua Wang
Keyword(s):  
Carbon Atom ◽  
Total Synthesis ◽  
Natural Product ◽  
Migration Strategy ◽  
Atom Migration ◽  
Product Assembly

Here we demonstrate recent strategic applications of 1,2-carbon atom migration reactions in complex natural product assembly.

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