High-Contrast Facile Imaging with Target-Directing Fluorescent Molecular Rotors, the N3-Modified Thioflavin T Derivatives

Biochemistry ◽  
2018 ◽  
Vol 58 (6) ◽  
pp. 493-498 ◽  
Author(s):  
Yuka Kataoka ◽  
Hiroto Fujita ◽  
Arina Afanaseva ◽  
Chioko Nagao ◽  
Kenji Mizuguchi ◽  
...  
Keyword(s):  
Thioflavin T ◽  
Molecular Rotors ◽  
High Contrast ◽  
Fluorescent Molecular Rotors ◽  
Thioflavin T Derivatives

Effect of Substituents on TICT Rate in Thioflavin T-Based Fluorescent Molecular Rotors

2019 ◽  
Vol 18 (03n04) ◽  
pp. 1940046
Author(s):  
V. I. Stsiapura ◽  
S. D. Gogoleva ◽  
A. A. Maskevich ◽  
O. V. Buganov ◽  
S. A. Tikhomirov ◽  
...  
Keyword(s):  
Excited States ◽  
Intramolecular Charge Transfer ◽  
Thioflavin T ◽  
Molecular Rotors ◽  
Molecular Fragments ◽  
Time Resolved ◽  
Fluorescent Molecular Rotors ◽  
Methoxy Groups ◽  
Donor Acceptor ◽  
Mutual Rotation

New fluorescent molecular rotors (FMRs) were developed by modification of the Thioflavin T (ThT) structure via introduction of methyl and methoxy groups. Effects of the substituents on fluorescence properties and twisted intramolecular charge transfer (TICT) rate in the excited state of the molecules were studied using steady-state fluorescence and time-resolved absorption spectroscopy. Quantum chemical calculations of the molecules in the ground and excited states were carried out to aid interpretation of the experimental results. Only cationic forms of ThT derivatives have FMR properties and exhibit viscosity-dependent fluorescence. The TICT rate was found to be affected by the size of the molecular fragments, which experience mutual rotation, dihedral angle [Formula: see text] between the fragments in the ground state as well as their donor/acceptor properties.

Development of99mTc-thioflavin-T derivatives for detection of systemic amyloidosis

2008 ◽  
Vol 51 (10) ◽  
pp. 357-367 ◽  
Author(s):  
K. Serdons ◽  
T. Verduyckt ◽  
J. Cleynhens ◽  
G. Bormans ◽  
A. Verbruggen
Keyword(s):  
Thioflavin T ◽  
Systemic Amyloidosis ◽  
Thioflavin T Derivatives

scholarly journals Julolidine fluorescent molecular rotors as vapour sensing probes in polystyrene films

2015 ◽  
Vol 113 ◽  
pp. 47-54 ◽  
Author(s):  
Giulio Martini ◽  
Elisa Martinelli ◽  
Giacomo Ruggeri ◽  
Giancarlo Galli ◽  
Andrea Pucci
Keyword(s):  
Molecular Rotors ◽  
Fluorescent Molecular Rotors

scholarly journals Intrinsic and Extrinsic Temperature-Dependency of Viscosity-Sensitive Fluorescent Molecular Rotors

2011 ◽  
Vol 22 (1) ◽  
pp. 457-465 ◽  
Author(s):  
Sarah Howell ◽  
Marianna Dakanali ◽  
Emmanuel A. Theodorakis ◽  
Mark A. Haidekker
Keyword(s):  
Molecular Rotors ◽  
Temperature Dependency ◽  
Fluorescent Molecular Rotors

Probing Polymerization Dynamics with Fluorescent Molecular Rotors and Magnetoelastic Sensors

2006 ◽  
Vol 4 (3) ◽  
pp. 257-261 ◽  
Author(s):  
Mark A. Haidekker ◽  
Darcy Lichlyter ◽  
Manu Ben Johny ◽  
Craig A. Grimes
Keyword(s):  
Molecular Rotors ◽  
Fluorescent Molecular Rotors ◽  
Magnetoelastic Sensors

scholarly journals Probing supramolecular protein assembly using covalently attached fluorescent molecular rotors

Biomaterials ◽  
2017 ◽  
Vol 139 ◽  
pp. 195-201 ◽  
Author(s):  
Markéta Kubánková ◽  
Ismael López-Duarte ◽  
James A. Bull ◽  
Devkee M. Vadukul ◽  
Louise C. Serpell ◽  
...  
Keyword(s):  
Protein Assembly ◽  
Molecular Rotors ◽  
Fluorescent Molecular Rotors
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