Interactions of the DNA Repair Enzyme Human Thymine DNA Glycosylase with Cognate and Noncognate DNA

Biochemistry ◽  
2018 ◽  
Vol 57 (39) ◽  
pp. 5654-5665 ◽  
Author(s):  
Natalia Kanaan ◽  
Petra Imhof
Keyword(s):  
Dna Repair ◽  
Dna Glycosylase ◽  
Repair Enzyme ◽  
Thymine Dna Glycosylase

The effect of p53 on the DNA repair enzyme Thymine-DNA Glycosylase

2008 ◽  
Vol 6 (9) ◽  
pp. 47
Author(s):  
N. Meireles da Costa ◽  
A. Hautefeuille ◽  
M. Pierre Cros ◽  
L.F. Ribeiro Pinto ◽  
P. Hainaut
Keyword(s):  
Dna Repair ◽  
Dna Glycosylase ◽  
Repair Enzyme ◽  
Thymine Dna Glycosylase

603 The Effect of p53 on the DNA Repair Enzyme Thymine DNA Glycosylase

2012 ◽  
Vol 48 ◽  
pp. S143-S144
Author(s):  
N. Meireles da Costa ◽  
A. Hautefeuille ◽  
M.P. Cros ◽  
M.E. Melendez ◽  
P. Swann ◽  
...  
Keyword(s):  
Dna Repair ◽  
Dna Glycosylase ◽  
Repair Enzyme ◽  
Thymine Dna Glycosylase

scholarly journals Histone deacetylase SIRT1 modulates and deacetylates DNA base excision repair enzyme thymine DNA glycosylase

2013 ◽  
Vol 456 (1) ◽  
pp. 89-98 ◽  
Author(s):  
Amrita Madabushi ◽  
Bor-Jang Hwang ◽  
Jin Jin ◽  
A-Lien Lu
Keyword(s):  
Dna Repair ◽  
Histone Deacetylase ◽  
Excision Repair ◽  
Dna Glycosylase ◽  
Repair Enzyme ◽  
Repair Gene ◽  
Thymine Dna Glycosylase ◽  
Dna Base Excision Repair ◽  
Dna Repair Gene ◽  
Base Excision

SIRT1 histone deacetylase interacts with the DNA repair enzyme thymine DNA glycosylase (TDG). SIRT1 inhibits TDG expression and deacetylates TDG to modulate TDG activity and substrate specificity. These interactions may mediate DNA repair, gene expression and drug cytotoxicity.

A mammalian cell line deficient in activity of the DNA repair enzyme 5-hydroxymethyluracil-DNA glycosylase is resistant to the toxic effects of the thymidine analog 5-hydroxymethyl-2'-deoxyuridine

1992 ◽  
Vol 12 (12) ◽  
pp. 5536-5540
Author(s):  
R J Boorstein ◽  
L N Chiu ◽  
G W Teebor
Keyword(s):  
Dna Repair ◽  
Cell Line ◽  
Mammalian Cell ◽  
Dna Glycosylase ◽  
Mammalian Cell Line ◽  
Repair Enzyme ◽  
Thymidine Analog ◽  
Large Numbers ◽  
Mechanism Of Toxicity ◽  
Base Excision

We isolated a mutant mammalian cell line lacking activity for the DNA repair enzyme 5-hydroxymethyluracil-DNA glycosylase (HmUra-DNA glycosylase). The mutant was isolated through its resistance to the thymidine analog 5-hydroxymethyl-2'-deoxyuridine (HmdUrd). The mutant incorporates HmdUrd into DNA to the same extent as the parent line but, lacking the repair enzyme, does not remove it. The phenotype of the mutant demonstrates that the toxicity of HmdUrd does not result from substitution of thymine in DNA by HmUra but rather from the removal via base excision of large numbers of HmUra residues in DNA. This finding elucidates a novel mechanism of toxicity for a xenobiotic nucleoside. Furthermore, the isolation of this line supports our hypothesis that the enzymatic repairability of HmUra derives not from its formation opposite adenine via the oxidation of thymine, but rather from its formation opposite guanine as a product of the oxidation and subsequent deamination of 5-methylcytosine.

scholarly journals Association of CBP/p300 Acetylase and Thymine DNA Glycosylase Links DNA Repair and Transcription

2002 ◽  
Vol 9 (2) ◽  
pp. 265-277 ◽  
Author(s):  
Marc Tini ◽  
Arndt Benecke ◽  
Soo-Joong Um ◽  
Joseph Torchia ◽  
Ronald M Evans ◽  
...  
Keyword(s):  
Dna Repair ◽  
Dna Glycosylase ◽  
Thymine Dna Glycosylase

Multiple microRNAs may regulate the DNA repair enzyme uracil-DNA glycosylase

DNA Repair ◽  
2013 ◽  
Vol 12 (1) ◽  
pp. 80-86 ◽  
Author(s):  
Siv A. Hegre ◽  
Pål Sætrom ◽  
Per A. Aas ◽  
Henrik S. Pettersen ◽  
Marit Otterlei ◽  
...  
Keyword(s):  
Dna Repair ◽  
Dna Glycosylase ◽  
Repair Enzyme ◽  
Uracil Dna Glycosylase

scholarly journals Molecular cloning of human uracil-DNA glycosylase, a highly conserved DNA repair enzyme.

1989 ◽  
Vol 8 (10) ◽  
pp. 3121-3125 ◽  
Author(s):  
L.C. Olsen ◽  
R. Aasland ◽  
C.U. Wittwer ◽  
H.E. Krokan ◽  
D.E. Helland
Keyword(s):  
Dna Repair ◽  
Molecular Cloning ◽  
Dna Glycosylase ◽  
Repair Enzyme ◽  
Uracil Dna Glycosylase
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