Structural Insight into the Discrimination between 8-Oxoguanine Glycosidic Conformers by DNA Repair Enzymes: A Molecular Dynamics Study of Human Oxoguanine Glycosylase 1 and Formamidopyrimidine-DNA Glycosylase

Biochemistry ◽  
2018 ◽  
Vol 57 (7) ◽  
pp. 1144-1154 ◽  
Author(s):  
Shahin Sowlati-Hashjin ◽  
Stacey D. Wetmore
Keyword(s):  
Molecular Dynamics ◽  
Dna Repair ◽  
Dna Glycosylase ◽  
Dna Repair Enzymes ◽  
Repair Enzymes ◽  
Structural Insight ◽  
Oxoguanine Glycosylase 1 ◽  
Insight Into

Induction of the DNA repair enzymes uracil DNA glycosylase and 3-methyladenine DNA glycosylase in regenerating rat liver

1981 ◽  
Vol 2 (7) ◽  
pp. 595-599 ◽  
Author(s):  
Charles T. Gombar ◽  
Edward J. Katz ◽  
Peter N. Magee ◽  
Michael A. Sirover
Keyword(s):  
Dna Repair ◽  
Rat Liver ◽  
Dna Glycosylase ◽  
Uracil Dna Glycosylase ◽  
Dna Repair Enzymes ◽  
Repair Enzymes ◽  
Regenerating Rat Liver

Rapid sensitive fluorescence assays for DNA endonucleases and DNA glycosylases

1984 ◽  
Vol 62 (12) ◽  
pp. 1275-1282 ◽  
Author(s):  
D. H. Evans ◽  
F. X. Bugeja ◽  
B. J. Yacyshyn ◽  
A. R. Morgan
Keyword(s):  
Dna Repair ◽  
Dnase I ◽  
Dna Glycosylase ◽  
Topological Properties ◽  
Dna Glycosylases ◽  
Ap Endonuclease ◽  
Dna Repair Enzymes ◽  
Repair Enzymes ◽  
Cell Extracts ◽  
Dna Repair Mutants

Using ethidium fluorescence as a probe and the unique topological properties of covalently closed circular (CCC) DNA's, picogram quantities of pancreatic DNase I can be detected. By chemically modifying CCC DNA's without the introduction of nicks, various DNA repair enzymes can be detected even in crude cell extracts. This has previously been done for AP endonucleases from yeast. In this paper we describe the formation of ultraviolet (UV) and bisulfite modified CCC DNA's for the detection of T4 UV endonuclease (a DNA glycosylase + AP endonuclease) and uracil-DNA glycosylases, respectively. These assays should be useful in the isolation of DNA repair mutants.

scholarly journals DASH-type cryptochromes – solved and open questions

2020 ◽  
Vol 401 (12) ◽  
pp. 1487-1493
Author(s):  
Stephan Kiontke ◽  
Tanja Göbel ◽  
Annika Brych ◽  
Alfred Batschauer
Keyword(s):  
Dna Repair ◽  
Circadian Clock ◽  
Blue Light ◽  
Dna Repair Enzymes ◽  
Repair Enzymes ◽  
Open Questions ◽  
Essential Components ◽  
Repair Activity ◽  
Almost All ◽  
Uv Lesions

AbstractDrosophila, Arabidopsis, Synechocystis, human (DASH)-type cryptochromes (cry-DASHs) form one subclade of the cryptochrome/photolyase family (CPF). CPF members are flavoproteins that act as DNA-repair enzymes (DNA-photolyases), or as ultraviolet(UV)-A/blue light photoreceptors (cryptochromes). In mammals, cryptochromes are essential components of the circadian clock feed-back loop. Cry-DASHs are present in almost all major taxa and were initially considered as photoreceptors. Later studies demonstrated DNA-repair activity that was, however, restricted to UV-lesions in single-stranded DNA. Very recent studies, particularly on microbial organisms, substantiated photoreceptor functions of cry-DASHs suggesting that they could be transitions between photolyases and cryptochromes.

DNA Repair Enzymes in Mammalian Cells

1977 ◽  
pp. 263-322 ◽  
Author(s):  
Errol C. Friedberg ◽  
Kern H. Cook ◽  
James Duncan ◽  
Kristien Mortelmans
Keyword(s):  
Dna Repair ◽  
Mammalian Cells ◽  
Dna Repair Enzymes ◽  
Repair Enzymes
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