scholarly journals Role of Glycanation and Convertase Maturation of Soluble Glypican-3 in Inhibiting Proliferation of Hepatocellular Carcinoma Cells

Biochemistry ◽  
2018 ◽  
Vol 57 (7) ◽  
pp. 1201-1211 ◽  
Author(s):  
Ahmad Saad ◽  
Benjamin Liet ◽  
Gilles Joucla ◽  
Xavier Santarelli ◽  
Justine Charpentier ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Carcinoma Cells ◽  
Hepatocellular Carcinoma Cells

scholarly journals MiR-141 Activates Nrf2-Dependent Antioxidant Pathway via Down-Regulating the Expression of Keap1 Conferring the Resistance of Hepatocellular Carcinoma Cells to 5-Fluorouracil

2015 ◽  
Vol 35 (6) ◽  
pp. 2333-2348 ◽  
Author(s):  
Liang Shi ◽  
Lili Wu ◽  
Zhanguo Chen ◽  
Jianrong Yang ◽  
Xiaofei Chen ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Cancer Therapy ◽  
Nuclear Translocation ◽  
Therapy Resistance ◽  
Parental Cell ◽  
Significant Inhibition ◽  
Carcinoma Cells ◽  
Pcr Analysis ◽  
Hepatocellular Carcinoma Cells

Background: Hepatocellular carcinoma (HCC) is one of the most lethal malignancies worldwide. A major cause for the failure of cancer therapy is the development of chemoresistance. Although progress has been made in the study of the mechanisms underlying cancer cells resistance, little is known about the role of microRNAs (miRNAs) in cancer therapy resistance. Methods and Results: Fifteen miRNAs, including 6 up-regulated miRNAs (> 2.0-fold) and 9 down-regulated miRNAs (< 0.5-fold) were differentially expressed in 5-fluorouracil-resistant and their parental cell-lines (HepG2, HepG2/5-FU) by miRNA microarrays. Microarray results were confirmed by validating quantitative real-time polymerase chain reaction (qRT-PCR) analysis. Up-regulation of miR-141 expression resulted in a significant inhibition of 5-FU-mediated cytotoxicity and apoptosis in various hepatocellular carcinoma cells-lines. Mechanically, miR-141 promoted Kelch-like ECH-associated protein 1 (Keap1) mRNA degradation by directly targeting the Keap1 3'untranslated region (3'UTR). Treatment with miR-141 mimics in parental HepG2 cells, restored miR-141 expression and reduced Keap1 levels, thereby resulting in erythroid transcription factor NFE2-L2 (Nrf2) nuclear translocation, activation of Nrf2-dependent HO-1 gene transcription, and subsequent enhancement in 5-FU resistance. Conversely, restoring the expression of Keap1 partly recovered 5-FU sensitivity by counteracting miR-141-mediated 5-FU resistance. Conclusion: Our study showed that miR-141 plays a key role in 5-FU resistance by down-regulating Keap1 expression, thereby reactivating the Nrf2-dependent antioxidant pathway, which may serve as a potential target for overcoming 5-FU resistance in hepatocellular carcinoma cells.

scholarly journals Role of ?1 integrins in adhesion and invasion of hepatocellular carcinoma cells

Hepatology ◽  
1999 ◽  
Vol 29 (1) ◽  
pp. 68-74 ◽  
Author(s):  
Akihide Masumoto ◽  
Shuichi Arao ◽  
Makoto Otsuki
Keyword(s):  
Hepatocellular Carcinoma ◽  
Carcinoma Cells ◽  
Hepatocellular Carcinoma Cells ◽  
Adhesion And Invasion

691 The Role of PPARγ Modulation in the Growth Inhibition of Hepatocellular Carcinoma Cells

2009 ◽  
Vol 136 (5) ◽  
pp. A-108
Author(s):  
Jun Yu ◽  
Bo Shen ◽  
Shiyan Wang ◽  
Chung-Wah Wu ◽  
Cleo NY Lam ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Growth Inhibition ◽  
Carcinoma Cells ◽  
Hepatocellular Carcinoma Cells

scholarly journals Targeting Long Non-Coding RNAs in Hepatocellular Carcinoma: Progress and Prospects

2021 ◽  
Vol 11 ◽  
Author(s):  
Xinrong Lin ◽  
Xiaosong Xiang ◽  
Bing Feng ◽  
Hao Zhou ◽  
Ting Wang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Survival Rate ◽  
Target Therapy ◽  
Therapy Resistance ◽  
Carcinoma Cells ◽  
Tumor Proliferation ◽  
Aberrant Expression ◽  
Hepatocellular Carcinoma Cells ◽  
Non Coding Rnas

Hepatocellular carcinoma is the fifth-ranked cancer worldwide with a relatively low five-year survival rate. Long non-coding RNAs are a group of RNAs with remarkable aberrant expression which could act on multiple bioprocesses and ultimately impact upon tumor proliferation, invasion, migration, metastasis, apoptosis, and therapy resistance in cancer cells including hepatocellular carcinoma cells. In recent years, long non-coding RNAs have been reported to be indispensable targets in clinical target therapy to stop the growth of cancer and prolong the lifespan of patients with hepatocellular carcinoma. In this review, we enumerate the signaling pathways and life activities affected by long non-coding RNAs in hepatocellular carcinoma cells to illustrate the role of long non-coding RNAs in the development and therapy resistance of hepatocellular carcinoma.

Sign in / Sign up

Export Citation Format

Share Document