scholarly journals The Mechanism of Regulation of Pantothenate Biosynthesis by the PanD–PanZ·AcCoA Complex Reveals an Additional Mode of Action for the AntimetaboliteN-Pentyl Pantothenamide (N5-Pan)

Biochemistry ◽  
2017 ◽  
Vol 56 (37) ◽  
pp. 4931-4939 ◽  
Author(s):  
Zoe L. P. Arnott ◽  
Shingo Nozaki ◽  
Diana C. F. Monteiro ◽  
Holly E. Morgan ◽  
Arwen R. Pearson ◽  
...  
Keyword(s):  
Mode Of Action ◽  
Additional Mode ◽  
Pantothenate Biosynthesis

scholarly journals Anticancer drug mithramycin interacts with core histones: An additional mode of action of the DNA groove binder

FEBS Open Bio ◽  
2014 ◽  
Vol 4 (1) ◽  
pp. 987-995 ◽  
Author(s):  
Amrita Banerjee ◽  
Sulagna Sanyal ◽  
Kirti K. Kulkarni ◽  
Kuladip Jana ◽  
Siddhartha Roy ◽  
...  
Keyword(s):  
Anticancer Drug ◽  
Mode Of Action ◽  
Additional Mode ◽  
Core Histones

Ellipticine Binds to a Human Telomere Sequence: An Additional Mode of Action as a Putative Anticancer Agent?

Biochemistry ◽  
2013 ◽  
Vol 52 (24) ◽  
pp. 4127-4137 ◽  
Author(s):  
Saptaparni Ghosh ◽  
Anirban Kar ◽  
Shantanu Chowdhury ◽  
Dipak Dasgupta
Keyword(s):  
Mode Of Action ◽  
Anticancer Agent ◽  
Telomere Sequence ◽  
Additional Mode ◽  
Human Telomere

scholarly journals Single and sequential applications of dicamba for the control of glyphosate-resistant common ragweed in glyphosate- and dicamba-resistant soybean

2018 ◽  
Vol 98 (3) ◽  
pp. 552-556
Author(s):  
Holly P. Byker ◽  
Annemarie C. Van Wely ◽  
Nadar Soltani ◽  
Mark B. Lawton ◽  
Darren E. Robinson ◽  
...  
Keyword(s):  
Weed Management ◽  
Mode Of Action ◽  
Management Practices ◽  
Yield Loss ◽  
Field Studies ◽  
Emergence Period ◽  
Roundup Ready ◽  
Common Ragweed ◽  
Additional Mode

Confirmation of glyphosate-resistant (GR) weeds in southwestern Ontario has led to a change in weed management practices, particularly in soybean. Registered soil-applied herbicides have been identified that have activity on GR common ragweed; however, due to the long emergence period of common ragweed, additional postemergence options are required. The recent development of glyphosate- and dicamba-resistant soybean (Roundup Ready Xtend soybean) allows for the preplant and postemergence application of dicamba. Three field studies were conducted in Ontario, Canada, in a field with confirmed GR common ragweed. Glyphosate-resistant common ragweed interference resulted in 75% yield loss in soybean compared with the weed-free check. At 4 wk after application, dicamba tank-mixed with glyphosate applied preplant only, postemergence only, or preplant followed by postemergence controlled GR common ragweed up to 94%, 87%, and 99%, respectively. The availability of dicamba for use in glyphosate- and dicamba-resistant soybean will provide an additional mode of action for weed management in soybean.

scholarly journals Meleagrin, a New FabI Inhibitor from Penicillium chryosogenum with at Least One Additional Mode of Action

PLoS ONE ◽  
2013 ◽  
Vol 8 (11) ◽  
pp. e78922 ◽  
Author(s):  
Chang Ji Zheng ◽  
Mi-Jin Sohn ◽  
Sangku Lee ◽  
Won-Gon Kim
Keyword(s):  
Mode Of Action ◽  
Additional Mode

Effects of 5-5'-Diphenyl-2-thiohydantoin (DPTH) and Thyroxine on the Ultrastructure and Chemical Composition of Rat Liver

1971 ◽  
Vol 29 ◽  
pp. 570-571
Author(s):  
E. A. Elfont ◽  
R. B. Tobin ◽  
D. G. Colton ◽  
M. A. Mehlman
Keyword(s):  
Chemical Composition ◽  
Rat Liver ◽  
Future Study ◽  
Mode Of Action ◽  
Liver Mitochondria ◽  
Rat Liver Mitochondria ◽  
Effective Inhibitor ◽  
Biochemical Effects ◽  
Glycerophosphate Dehydrogenase ◽  
Stimulation Of

Summary5,-5'-diphenyl-2-thiohydantoin (DPTH) is an effective inhibitor of thyroxine (T4) stimulation of α-glycerophosphate dehydrogenase in rat liver mitochondria. Because this finding indicated a possible tool for future study of the mode of action of thyroxine, the ultrastructural and biochemical effects of DPTH and/or thyroxine on rat liver mere investigated.Rats were fed either standard or DPTH (0.06%) diet for 30 days before T4 (250 ug/kg/day) was injected. Injection of T4 occurred daily for 10 days prior to sacrifice. After removal of the liver and kidneys, part of the tissue was frozen at -50°C for later biocheailcal analyses, while the rest was prefixed in buffered 3.5X glutaraldehyde (390 mOs) and post-fixed in buffered 1Z OsO4 (376 mOs). Tissues were embedded in Araldlte 502 and the sections examined in a Zeiss EM 9S.Hepatocytes from hyperthyroid rats (Fig. 2) demonstrated enlarged and more numerous mitochondria than those of controls (Fig. 1). Glycogen was almost totally absent from the cytoplasm of the T4-treated rats.

Mode of action of 6-oxophenolic triterpenoids against Bacillus subtilis

Planta Medica ◽  
2007 ◽  
Vol 73 (09) ◽  
Author(s):  
L Moujir ◽  
L de León ◽  
IL Bazzocchi
Keyword(s):  
Bacillus Subtilis ◽  
Mode Of Action
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